Echinocandin Failure Case Due to a Previously Unreported FKS1 Mutation in Candida krusei

Rasmus Hare Jensen, Ulrik Stenz Justesen, Annika Rewes, David S Perlin, Maiken Cavling Arendrup

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Abstrakt

Echinocandins are the preferred therapy for invasive infections due to Candida krusei. We present here a case of clinical failure involving C. krusei with a characteristic FKS1 hot spot mutation not previously reported in C. krusei that was isolated after 14 days of treatment. Anidulafungin MICs were elevated by ≥5 dilution steps above the clinical breakpoint but by only 1 step for a Candida albicans isolate harboring the corresponding mutation, suggesting a notable species-specific difference in the MIC increase conferred by this mutation.

OriginalsprogEngelsk
TidsskriftAntimicrobial Agents and Chemotherapy
Vol/bind58
Udgave nummer6
Sider (fra-til)3550-3552
ISSN0066-4804
DOI
StatusUdgivet - jun. 2014

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