Early-life sensitization to hen's egg predicts asthma and rhinoconjunctivitis at 14 years of age

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Background: Sensitization to both inhalant and food allergens has been shown to be risk factors for development of asthma and rhinoconjunctivitis (RC). However, few studies have addressed the role of transient or persistent IgE sensitization to specific allergens in early life for later development of allergic diseases. The aim of this study was to explore the association between transient and persistent sensitization in early life and the development of asthma and RC at 6 and 14 years. Methods: The Danish Allergy Research Center (DARC) cohort is a prospective non-interventional birth cohort study comprising 562 children. For the purpose of this study, we examined a subgroup of the original cohort with specific IgE measured at, at least 3 of 4 follow-ups between 3 and 18 months of age (n = 366). Multiple logistic regression models were used to investigate the association between transient and persistent early-life sensitization to groups of and to individual allergens and asthma and RC at 6 and 14 years compared to a reference group with no sensitization. Results: Both transient early-life sensitization and persistent early-life sensitization to cow's milk or hen's egg proteins were associated with asthma (aOR 3.99[1.41-11.32] and 5.95[1.78-19.92]) and RC (aOR 2.94[1.19-7.28] and 6.18[1.86-20.53]) at 14 years, this association being driven mainly by sensitization to hen's egg. Transient early-life sensitization to house dust mite (HDM) had increased risk of asthma (aOR 3.80[1.17-12.41]) at 14 years. Conclusions: Early transient IgE sensitization and persistent IgE sensitization to hen's egg were associated with asthma and RC at 14 years. Furthermore, sensitization to HDM was associated with asthma at 14 years.

OriginalsprogEngelsk
TidsskriftPediatric Allergy and Immunology
Vol/bind28
Udgave nummer8
Sider (fra-til)776–783
ISSN0905-6157
DOI
StatusUdgivet - dec. 2017

Fingeraftryk

Ovum
Allergens
Pyroglyphidae
Logistic Models
Egg Proteins
Hypersensitivity
Cohort Studies
Food
Research

Citer dette

@article{a34cd441cbd54587bdd25044e463130b,
title = "Early-life sensitization to hen's egg predicts asthma and rhinoconjunctivitis at 14 years of age",
abstract = "Background: Sensitization to both inhalant and food allergens has been shown to be risk factors for development of asthma and rhinoconjunctivitis (RC). However, few studies have addressed the role of transient or persistent IgE sensitization to specific allergens in early life for later development of allergic diseases. The aim of this study was to explore the association between transient and persistent sensitization in early life and the development of asthma and RC at 6 and 14 years. Methods: The Danish Allergy Research Center (DARC) cohort is a prospective non-interventional birth cohort study comprising 562 children. For the purpose of this study, we examined a subgroup of the original cohort with specific IgE measured at, at least 3 of 4 follow-ups between 3 and 18 months of age (n = 366). Multiple logistic regression models were used to investigate the association between transient and persistent early-life sensitization to groups of and to individual allergens and asthma and RC at 6 and 14 years compared to a reference group with no sensitization. Results: Both transient early-life sensitization and persistent early-life sensitization to cow's milk or hen's egg proteins were associated with asthma (aOR 3.99[1.41-11.32] and 5.95[1.78-19.92]) and RC (aOR 2.94[1.19-7.28] and 6.18[1.86-20.53]) at 14 years, this association being driven mainly by sensitization to hen's egg. Transient early-life sensitization to house dust mite (HDM) had increased risk of asthma (aOR 3.80[1.17-12.41]) at 14 years. Conclusions: Early transient IgE sensitization and persistent IgE sensitization to hen's egg were associated with asthma and RC at 14 years. Furthermore, sensitization to HDM was associated with asthma at 14 years.",
keywords = "Journal Article, predictors, rhinoconjunctivitis, childhood, birth cohort, transient, asthma, sensitization, persistent, Prospective Studies, Egg Hypersensitivity/complications, Follow-Up Studies, Asthma/complications, Humans, Risk Factors, Infant, Logistic Models, Male, Rhinitis, Allergic/complications, Conjunctivitis/complications, Adolescent, Female, Child",
author = "Christiansen, {Elisabeth Soegaard} and Kjaer, {Henrik Fomsgaard} and Esben Eller and Carsten Bindslev-Jensen and Arne H{\o}st and Mortz, {Charlotte Gotthard} and Susanne Halken",
note = "This article is protected by copyright. All rights reserved.",
year = "2017",
month = "12",
doi = "10.1111/pai.12815",
language = "English",
volume = "28",
pages = "776–783",
journal = "Pediatric Allergy and Immunology",
issn = "0905-6157",
publisher = "Wiley-Blackwell",
number = "8",

}

TY - JOUR

T1 - Early-life sensitization to hen's egg predicts asthma and rhinoconjunctivitis at 14 years of age

AU - Christiansen, Elisabeth Soegaard

AU - Kjaer, Henrik Fomsgaard

AU - Eller, Esben

AU - Bindslev-Jensen, Carsten

AU - Høst, Arne

AU - Mortz, Charlotte Gotthard

AU - Halken, Susanne

N1 - This article is protected by copyright. All rights reserved.

PY - 2017/12

Y1 - 2017/12

N2 - Background: Sensitization to both inhalant and food allergens has been shown to be risk factors for development of asthma and rhinoconjunctivitis (RC). However, few studies have addressed the role of transient or persistent IgE sensitization to specific allergens in early life for later development of allergic diseases. The aim of this study was to explore the association between transient and persistent sensitization in early life and the development of asthma and RC at 6 and 14 years. Methods: The Danish Allergy Research Center (DARC) cohort is a prospective non-interventional birth cohort study comprising 562 children. For the purpose of this study, we examined a subgroup of the original cohort with specific IgE measured at, at least 3 of 4 follow-ups between 3 and 18 months of age (n = 366). Multiple logistic regression models were used to investigate the association between transient and persistent early-life sensitization to groups of and to individual allergens and asthma and RC at 6 and 14 years compared to a reference group with no sensitization. Results: Both transient early-life sensitization and persistent early-life sensitization to cow's milk or hen's egg proteins were associated with asthma (aOR 3.99[1.41-11.32] and 5.95[1.78-19.92]) and RC (aOR 2.94[1.19-7.28] and 6.18[1.86-20.53]) at 14 years, this association being driven mainly by sensitization to hen's egg. Transient early-life sensitization to house dust mite (HDM) had increased risk of asthma (aOR 3.80[1.17-12.41]) at 14 years. Conclusions: Early transient IgE sensitization and persistent IgE sensitization to hen's egg were associated with asthma and RC at 14 years. Furthermore, sensitization to HDM was associated with asthma at 14 years.

AB - Background: Sensitization to both inhalant and food allergens has been shown to be risk factors for development of asthma and rhinoconjunctivitis (RC). However, few studies have addressed the role of transient or persistent IgE sensitization to specific allergens in early life for later development of allergic diseases. The aim of this study was to explore the association between transient and persistent sensitization in early life and the development of asthma and RC at 6 and 14 years. Methods: The Danish Allergy Research Center (DARC) cohort is a prospective non-interventional birth cohort study comprising 562 children. For the purpose of this study, we examined a subgroup of the original cohort with specific IgE measured at, at least 3 of 4 follow-ups between 3 and 18 months of age (n = 366). Multiple logistic regression models were used to investigate the association between transient and persistent early-life sensitization to groups of and to individual allergens and asthma and RC at 6 and 14 years compared to a reference group with no sensitization. Results: Both transient early-life sensitization and persistent early-life sensitization to cow's milk or hen's egg proteins were associated with asthma (aOR 3.99[1.41-11.32] and 5.95[1.78-19.92]) and RC (aOR 2.94[1.19-7.28] and 6.18[1.86-20.53]) at 14 years, this association being driven mainly by sensitization to hen's egg. Transient early-life sensitization to house dust mite (HDM) had increased risk of asthma (aOR 3.80[1.17-12.41]) at 14 years. Conclusions: Early transient IgE sensitization and persistent IgE sensitization to hen's egg were associated with asthma and RC at 14 years. Furthermore, sensitization to HDM was associated with asthma at 14 years.

KW - Journal Article

KW - predictors

KW - rhinoconjunctivitis

KW - childhood

KW - birth cohort

KW - transient

KW - asthma

KW - sensitization

KW - persistent

KW - Prospective Studies

KW - Egg Hypersensitivity/complications

KW - Follow-Up Studies

KW - Asthma/complications

KW - Humans

KW - Risk Factors

KW - Infant

KW - Logistic Models

KW - Male

KW - Rhinitis, Allergic/complications

KW - Conjunctivitis/complications

KW - Adolescent

KW - Female

KW - Child

U2 - 10.1111/pai.12815

DO - 10.1111/pai.12815

M3 - Journal article

C2 - 28981985

VL - 28

SP - 776

EP - 783

JO - Pediatric Allergy and Immunology

JF - Pediatric Allergy and Immunology

SN - 0905-6157

IS - 8

ER -