Early life mortality risks in opposite-sex and same-sex twins: a Danish cohort study of the twin testosterone transfer hypothesis

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Resumé

Purpose
To investigate the twin testosterone transfer (TTT) hypothesis by comparing early-life mortality risks of opposite-sex (OS) and same-sex (SS) twins during the first 15 years of life.

Methods
We performed a population-based cohort study to compare mortality in OS and SS twins. We included 68,629 live-born Danish twins from 1973 to 2009 identified through the Danish Twin Registry and performed piecewise stratified Cox regression and log-binomial regression.

Results
Among 1933 deaths, we found significantly higher mortality for twin boys than for twin girls. For both sexes, OS twins had lower mortality than SS twins; the difference persisted for the first year of life for boys and for the first week of life for girls.

Conclusions
Although the mortality risk for OS boys was in the expected direction according to the TTT hypothesis, the results for OS girls pointed in the opposite direction, providing no clear evidence for the TTT hypothesis.
OriginalsprogEngelsk
TidsskriftAnnals of Epidemiology
Vol/bind27
Udgave nummer2
Sider (fra-til)115–120.e2
ISSN1047-2797
DOI
StatusUdgivet - 2017

Fingeraftryk

Cohort Studies
Registries
Population

Citer dette

@article{3937ea6f771246e393a9ea3de80a0413,
title = "Early life mortality risks in opposite-sex and same-sex twins: a Danish cohort study of the twin testosterone transfer hypothesis",
abstract = "PurposeTo investigate the twin testosterone transfer (TTT) hypothesis by comparing early-life mortality risks of opposite-sex (OS) and same-sex (SS) twins during the first 15 years of life.MethodsWe performed a population-based cohort study to compare mortality in OS and SS twins. We included 68,629 live-born Danish twins from 1973 to 2009 identified through the Danish Twin Registry and performed piecewise stratified Cox regression and log-binomial regression.ResultsAmong 1933 deaths, we found significantly higher mortality for twin boys than for twin girls. For both sexes, OS twins had lower mortality than SS twins; the difference persisted for the first year of life for boys and for the first week of life for girls.ConclusionsAlthough the mortality risk for OS boys was in the expected direction according to the TTT hypothesis, the results for OS girls pointed in the opposite direction, providing no clear evidence for the TTT hypothesis.",
author = "{Juel Ahrenfeldt}, Linda and Larsen, {Lisbeth Aagaard} and Rune Lindahl-Jacobsen and Axel Skytthe and Hjelmborg, {Jacob v. B.} and S{\"o}ren M{\"o}ller and Kaare Christensen",
year = "2017",
doi = "10.1016/j.annepidem.2016.11.011",
language = "English",
volume = "27",
pages = "115–120.e2",
journal = "Annals of Epidemiology",
issn = "1047-2797",
publisher = "Elsevier",
number = "2",

}

TY - JOUR

T1 - Early life mortality risks in opposite-sex and same-sex twins

T2 - a Danish cohort study of the twin testosterone transfer hypothesis

AU - Juel Ahrenfeldt, Linda

AU - Larsen, Lisbeth Aagaard

AU - Lindahl-Jacobsen, Rune

AU - Skytthe, Axel

AU - Hjelmborg, Jacob v. B.

AU - Möller, Sören

AU - Christensen, Kaare

PY - 2017

Y1 - 2017

N2 - PurposeTo investigate the twin testosterone transfer (TTT) hypothesis by comparing early-life mortality risks of opposite-sex (OS) and same-sex (SS) twins during the first 15 years of life.MethodsWe performed a population-based cohort study to compare mortality in OS and SS twins. We included 68,629 live-born Danish twins from 1973 to 2009 identified through the Danish Twin Registry and performed piecewise stratified Cox regression and log-binomial regression.ResultsAmong 1933 deaths, we found significantly higher mortality for twin boys than for twin girls. For both sexes, OS twins had lower mortality than SS twins; the difference persisted for the first year of life for boys and for the first week of life for girls.ConclusionsAlthough the mortality risk for OS boys was in the expected direction according to the TTT hypothesis, the results for OS girls pointed in the opposite direction, providing no clear evidence for the TTT hypothesis.

AB - PurposeTo investigate the twin testosterone transfer (TTT) hypothesis by comparing early-life mortality risks of opposite-sex (OS) and same-sex (SS) twins during the first 15 years of life.MethodsWe performed a population-based cohort study to compare mortality in OS and SS twins. We included 68,629 live-born Danish twins from 1973 to 2009 identified through the Danish Twin Registry and performed piecewise stratified Cox regression and log-binomial regression.ResultsAmong 1933 deaths, we found significantly higher mortality for twin boys than for twin girls. For both sexes, OS twins had lower mortality than SS twins; the difference persisted for the first year of life for boys and for the first week of life for girls.ConclusionsAlthough the mortality risk for OS boys was in the expected direction according to the TTT hypothesis, the results for OS girls pointed in the opposite direction, providing no clear evidence for the TTT hypothesis.

U2 - 10.1016/j.annepidem.2016.11.011

DO - 10.1016/j.annepidem.2016.11.011

M3 - Journal article

C2 - 28024904

VL - 27

SP - 115–120.e2

JO - Annals of Epidemiology

JF - Annals of Epidemiology

SN - 1047-2797

IS - 2

ER -