Early life exposures to perfluoroalkyl substances in relation to adipokine hormone levels at birth and during childhood

Colleen Shelly, Philippe Grandjean, Youssef Oulhote, Peter Plomgaard, Ruth Frikke-Schmidt, Flemming Nielsen, Denis Zmirou-Navier, Pal Weihe, Damaskini Valvi

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Resumé

BACKGROUND: Birth cohort studies have linked exposure to perfluoroalkyl substances (PFASs) with child anthropometry. Metabolic hormone dysregulation needs to be considered as a potential adverse outcome pathway. We examined the associations between PFAS exposures and concentrations of adipokine hormones from birth to adolescence.

METHODS: We studied 80 mother-child pairs from a Faroese cohort born in 1997-2000. Five PFASs were measured in maternal pregnancy serum and child serum at ages 5, 7 and 13 years. Leptin, adiponectin and resistin were analyzed in cord serum and child serum at the same ages. We fitted multivariable-adjusted generalized estimating equations to assess the associations of PFASs at each age with repeated adipokine concentrations at concurrent and subsequent ages.

RESULTS: We observed tendencies of inverse associations between PFASs and adipokine hormones specific to particular ages and child sex. Significant associations with all adipokines were observed for maternal and child 5-year serum PFAS concentrations, whereas associations for PFASs measured at ages 7-13 years were mostly null. The inverse associations with leptin and adiponectin were mainly seen in females, whereas the inverse PFAS associations with resistin levels were mainly seen in males. Estimates for significant associations (at p-value<0.05) suggested mean decreases in hormone levels (range) by 38%-89% for leptin, 16%-70% for adiponectin, and 33%-62% for resistin for each 2-fold increase in serum-PFAS concentrations.

CONCLUSIONS: These findings suggest adipokine hormone dysregulation in early life as a potential pathway underlying PFAS-related health outcomes, and underscore the need to further account for susceptibility windows and sex-dimorphic effects in future investigations.

OriginalsprogEngelsk
TidsskriftThe Journal of clinical endocrinology and metabolism
Vol/bind104
Udgave nummer11
Sider (fra-til)5338-5348
ISSN0021-972X
DOI
StatusUdgivet - 1. nov. 2019

Fingeraftryk

Adipokines
Resistin
Hormones
Adiponectin
Leptin
Serum
Mothers
Anthropometry
Health
Cohort Studies

Bibliografisk note

Copyright © 2019 Endocrine Society.

Citer dette

Shelly, Colleen ; Grandjean, Philippe ; Oulhote, Youssef ; Plomgaard, Peter ; Frikke-Schmidt, Ruth ; Nielsen, Flemming ; Zmirou-Navier, Denis ; Weihe, Pal ; Valvi, Damaskini. / Early life exposures to perfluoroalkyl substances in relation to adipokine hormone levels at birth and during childhood. I: The Journal of clinical endocrinology and metabolism. 2019 ; Bind 104, Nr. 11. s. 5338-5348.
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title = "Early life exposures to perfluoroalkyl substances in relation to adipokine hormone levels at birth and during childhood",
abstract = "BACKGROUND: Birth cohort studies have linked exposure to perfluoroalkyl substances (PFASs) with child anthropometry. Metabolic hormone dysregulation needs to be considered as a potential adverse outcome pathway. We examined the associations between PFAS exposures and concentrations of adipokine hormones from birth to adolescence.METHODS: We studied 80 mother-child pairs from a Faroese cohort born in 1997-2000. Five PFASs were measured in maternal pregnancy serum and child serum at ages 5, 7 and 13 years. Leptin, adiponectin and resistin were analyzed in cord serum and child serum at the same ages. We fitted multivariable-adjusted generalized estimating equations to assess the associations of PFASs at each age with repeated adipokine concentrations at concurrent and subsequent ages.RESULTS: We observed tendencies of inverse associations between PFASs and adipokine hormones specific to particular ages and child sex. Significant associations with all adipokines were observed for maternal and child 5-year serum PFAS concentrations, whereas associations for PFASs measured at ages 7-13 years were mostly null. The inverse associations with leptin and adiponectin were mainly seen in females, whereas the inverse PFAS associations with resistin levels were mainly seen in males. Estimates for significant associations (at p-value<0.05) suggested mean decreases in hormone levels (range) by 38{\%}-89{\%} for leptin, 16{\%}-70{\%} for adiponectin, and 33{\%}-62{\%} for resistin for each 2-fold increase in serum-PFAS concentrations.CONCLUSIONS: These findings suggest adipokine hormone dysregulation in early life as a potential pathway underlying PFAS-related health outcomes, and underscore the need to further account for susceptibility windows and sex-dimorphic effects in future investigations.",
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Early life exposures to perfluoroalkyl substances in relation to adipokine hormone levels at birth and during childhood. / Shelly, Colleen; Grandjean, Philippe; Oulhote, Youssef; Plomgaard, Peter; Frikke-Schmidt, Ruth; Nielsen, Flemming; Zmirou-Navier, Denis; Weihe, Pal; Valvi, Damaskini.

I: The Journal of clinical endocrinology and metabolism, Bind 104, Nr. 11, 01.11.2019, s. 5338-5348.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Early life exposures to perfluoroalkyl substances in relation to adipokine hormone levels at birth and during childhood

AU - Shelly, Colleen

AU - Grandjean, Philippe

AU - Oulhote, Youssef

AU - Plomgaard, Peter

AU - Frikke-Schmidt, Ruth

AU - Nielsen, Flemming

AU - Zmirou-Navier, Denis

AU - Weihe, Pal

AU - Valvi, Damaskini

N1 - Copyright © 2019 Endocrine Society.

PY - 2019/11/1

Y1 - 2019/11/1

N2 - BACKGROUND: Birth cohort studies have linked exposure to perfluoroalkyl substances (PFASs) with child anthropometry. Metabolic hormone dysregulation needs to be considered as a potential adverse outcome pathway. We examined the associations between PFAS exposures and concentrations of adipokine hormones from birth to adolescence.METHODS: We studied 80 mother-child pairs from a Faroese cohort born in 1997-2000. Five PFASs were measured in maternal pregnancy serum and child serum at ages 5, 7 and 13 years. Leptin, adiponectin and resistin were analyzed in cord serum and child serum at the same ages. We fitted multivariable-adjusted generalized estimating equations to assess the associations of PFASs at each age with repeated adipokine concentrations at concurrent and subsequent ages.RESULTS: We observed tendencies of inverse associations between PFASs and adipokine hormones specific to particular ages and child sex. Significant associations with all adipokines were observed for maternal and child 5-year serum PFAS concentrations, whereas associations for PFASs measured at ages 7-13 years were mostly null. The inverse associations with leptin and adiponectin were mainly seen in females, whereas the inverse PFAS associations with resistin levels were mainly seen in males. Estimates for significant associations (at p-value<0.05) suggested mean decreases in hormone levels (range) by 38%-89% for leptin, 16%-70% for adiponectin, and 33%-62% for resistin for each 2-fold increase in serum-PFAS concentrations.CONCLUSIONS: These findings suggest adipokine hormone dysregulation in early life as a potential pathway underlying PFAS-related health outcomes, and underscore the need to further account for susceptibility windows and sex-dimorphic effects in future investigations.

AB - BACKGROUND: Birth cohort studies have linked exposure to perfluoroalkyl substances (PFASs) with child anthropometry. Metabolic hormone dysregulation needs to be considered as a potential adverse outcome pathway. We examined the associations between PFAS exposures and concentrations of adipokine hormones from birth to adolescence.METHODS: We studied 80 mother-child pairs from a Faroese cohort born in 1997-2000. Five PFASs were measured in maternal pregnancy serum and child serum at ages 5, 7 and 13 years. Leptin, adiponectin and resistin were analyzed in cord serum and child serum at the same ages. We fitted multivariable-adjusted generalized estimating equations to assess the associations of PFASs at each age with repeated adipokine concentrations at concurrent and subsequent ages.RESULTS: We observed tendencies of inverse associations between PFASs and adipokine hormones specific to particular ages and child sex. Significant associations with all adipokines were observed for maternal and child 5-year serum PFAS concentrations, whereas associations for PFASs measured at ages 7-13 years were mostly null. The inverse associations with leptin and adiponectin were mainly seen in females, whereas the inverse PFAS associations with resistin levels were mainly seen in males. Estimates for significant associations (at p-value<0.05) suggested mean decreases in hormone levels (range) by 38%-89% for leptin, 16%-70% for adiponectin, and 33%-62% for resistin for each 2-fold increase in serum-PFAS concentrations.CONCLUSIONS: These findings suggest adipokine hormone dysregulation in early life as a potential pathway underlying PFAS-related health outcomes, and underscore the need to further account for susceptibility windows and sex-dimorphic effects in future investigations.

U2 - 10.1210/jc.2019-00385

DO - 10.1210/jc.2019-00385

M3 - Journal article

C2 - 31216000

VL - 104

SP - 5338

EP - 5348

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 11

ER -