EAACI-Leitlinien zur allergen-spezifischen Immuntherapie: Insektengiftallergie

G. J. Sturm, E-M Varga, G. Roberts, H. Mosbech, M. B. Bilo, C. A. Akdis, D. Antol'in-Ame'rigo, E. Cichocka-Jarosz, R. Gawlik, T. Jakob, M. Kosnik, J. Lange, E. Mingomataj, D. Mitsias I, M. Ollert, J. N. G. Oude Elberink, O. Pfaar, C. Pitsios, V Pravettoni, F. RueffB. A. Sin, I Agache, E. Angier, S. Arasi, M. A. Caldero'n, M. Femandez-Rivas, S. Halken, M. Jute, S. Lau, G. B. Pajno, R. van Ree, D. Ryan, O. Spranger, R. G. van VVijk, S. Dhami, H. Zaman, A. Sheikh, A. Muraro

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Abstrakt

Hymenoptera venom allergy is a potentially life-threatening allergic reaction following a honeybee, vespid, or ant sting. Systemic-allergic sting reactions have been reported in up to 7.5.4threatening anaphylaxis. Patients should carry an emergency kit containing an adrenaline autoinjector, H1-antihistamines, and corticostcroids depending on the severity of their previous sting reaction(s). The only treatment to prevent further systemic sting reactions is venom immunotherapy. This guideline has been prepared by the European Academy of Allergy and Clinical Immunology's (EAACI) Taskforce on Venom Immunotherapy as part of the EAACI Guidelines on Allergen Immunotherapy initiative. The guideline aims to provide evidence-based recommendations for the use of venom immunotherapy, has been informed by a formal systematic review and meta-analysis and produced using the Appraisal of Guidelines for Research and Evaluation (AGREE II) approach. The process included representation from a range of stakeholders. Venom immunotherapy is indicated in venom-allergic children and adults to prevent further moderate-to-severe systemic sting reactions. Venom immunotherapy is also recommended in adults with only generalized skin reactions as it results in significant improvements in quality of life compared to carrying an adrenaline autoinjector. This guideline aims to give practical advice on performing venom immunotherapy. Key sections cover general considerations before initiating venom immunotherapy, evidence-based clinical recommendations, risk factors for adverse events and for relapse of systemic sting reaction, and a summary of gaps in the evidence.
Bidragets oversatte titelEAACI guidelines on allergen immunotherapy: Hymenoptera venom allergy
OriginalsprogTysk
TidsskriftAllergologie
Vol/bind43
Udgave nummer5
Sider (fra-til)176-203
ISSN0344-5062
DOI
StatusUdgivet - maj 2020

Emneord

  • Anaphylaxis
  • Effectiveness
  • Hymenoptera venom allergy
  • Safety
  • Venom immunotherapy

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