Resumé
To test the hypothesis that halothane hepatitis is caused by a combination of altered drug metabolism and an immunoallergic disposition, the metabolism of antipyrine, metronidazole, sparteine, phenytoin, and racemic R- and S-mephenytoin was investigated in seven subjects with previous halothane hepatitis. The HLA tissue types and the complement C3 phenotypes were also determined. The metabolism of antipyrine and metronidazole was within normal range in all subjects, and they were all fast or extensive metabolizers of sparteine, mephenytoin, and phenytoin. HLA tissue types were unremarkable. Five of the seven subjects had complement C3 phenotypes F or FS. In the general population phenotype S is the most common, but the difference in complement C3 phenotypes is not statistically significant (p = 0.07). We conclude, although in a limited number of patients, that subjects with previous halothane hepatitis do not appear to be different from controls with regard to drug metabolism and HLA tissue type. The possibility of a higher frequency of complement C3 phenotype F and FS needs further investigation.
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Scandinavian Journal of Gastroenterology |
| Vol/bind | 28 |
| Udgave nummer | 8 |
| Sider (fra-til) | 677-680 |
| Antal sider | 4 |
| ISSN | 0036-5521 |
| DOI | |
| Status | Udgivet - 1. jan. 1993 |
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Drug metabolism and genetic polymorphism in subjects with previous halothane hepatitis. / Ranek, L.; Dalhoff, K.; Poulsen, H. Enghusen; Brøsen, K.; Flachs, H.; Loft, S.; Wantzin, P.
I: Scandinavian Journal of Gastroenterology, Bind 28, Nr. 8, 01.01.1993, s. 677-680.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
TY - JOUR
T1 - Drug metabolism and genetic polymorphism in subjects with previous halothane hepatitis
AU - Ranek, L.
AU - Dalhoff, K.
AU - Poulsen, H. Enghusen
AU - Brøsen, K.
AU - Flachs, H.
AU - Loft, S.
AU - Wantzin, P.
PY - 1993/1/1
Y1 - 1993/1/1
N2 - To test the hypothesis that halothane hepatitis is caused by a combination of altered drug metabolism and an immunoallergic disposition, the metabolism of antipyrine, metronidazole, sparteine, phenytoin, and racemic R- and S-mephenytoin was investigated in seven subjects with previous halothane hepatitis. The HLA tissue types and the complement C3 phenotypes were also determined. The metabolism of antipyrine and metronidazole was within normal range in all subjects, and they were all fast or extensive metabolizers of sparteine, mephenytoin, and phenytoin. HLA tissue types were unremarkable. Five of the seven subjects had complement C3 phenotypes F or FS. In the general population phenotype S is the most common, but the difference in complement C3 phenotypes is not statistically significant (p = 0.07). We conclude, although in a limited number of patients, that subjects with previous halothane hepatitis do not appear to be different from controls with regard to drug metabolism and HLA tissue type. The possibility of a higher frequency of complement C3 phenotype F and FS needs further investigation.
AB - To test the hypothesis that halothane hepatitis is caused by a combination of altered drug metabolism and an immunoallergic disposition, the metabolism of antipyrine, metronidazole, sparteine, phenytoin, and racemic R- and S-mephenytoin was investigated in seven subjects with previous halothane hepatitis. The HLA tissue types and the complement C3 phenotypes were also determined. The metabolism of antipyrine and metronidazole was within normal range in all subjects, and they were all fast or extensive metabolizers of sparteine, mephenytoin, and phenytoin. HLA tissue types were unremarkable. Five of the seven subjects had complement C3 phenotypes F or FS. In the general population phenotype S is the most common, but the difference in complement C3 phenotypes is not statistically significant (p = 0.07). We conclude, although in a limited number of patients, that subjects with previous halothane hepatitis do not appear to be different from controls with regard to drug metabolism and HLA tissue type. The possibility of a higher frequency of complement C3 phenotype F and FS needs further investigation.
KW - Antipyrine
KW - Complement 3C
KW - Halothane
KW - Hepatitis
KW - HLA antigens
KW - Mephenytoin
KW - Metronidazole
KW - Polymorphism (genetics)
KW - Sparteine
UR - http://www.scopus.com/inward/record.url?scp=0027327588&partnerID=8YFLogxK
U2 - 10.3109/00365529309098271
DO - 10.3109/00365529309098271
M3 - Journal article
C2 - 8210981
AN - SCOPUS:0027327588
VL - 28
SP - 677
EP - 680
JO - Scandinavian Journal of Gastroenterology
JF - Scandinavian Journal of Gastroenterology
SN - 0036-5521
IS - 8
ER -