Resumé

Sialorrhoea is a common adverse effect of a range of medicines, primarily clozapine. At least a third of patients treated with clozapine suffer from sialorrhoea, and the consequences of this can be socially stigmatising and lead to non-adherence. The treatment options are limited and primarily centered around muscarinic antagonism. We suggest non-pharmacological interventions followed by locally applied atropine or glycopyrrolate. If systemic treatment is necessary, amisulpride, benztropine, or terazosin may be attempted.
OriginalsprogEngelsk
TidsskriftAdverse Drug Reaction Bulletin
Vol/bind313
Udgave nummer1
Sider (fra-til)1211–1214
ISSN0044-6394
DOI
StatusUdgivet - dec. 2018

Fingeraftryk

Sialorrhea
Terazosin
Clozapine
Glycopyrrolate
Pharmaceutical Preparations
Cholinergic Agents
sultopride

Citer dette

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title = "Drug-induced Sialorrhoea",
abstract = "Sialorrhoea is a common adverse effect of a range of medicines, primarily clozapine. At least a third of patients treated with clozapine suffer from sialorrhoea, and the consequences of this can be socially stigmatising and lead to non-adherence. The treatment options are limited and primarily centered around muscarinic antagonism. We suggest non-pharmacological interventions followed by locally applied atropine or glycopyrrolate. If systemic treatment is necessary, amisulpride, benztropine, or terazosin may be attempted.",
author = "Haastrup, {Maija Bruun} and Henriksen, {Daniel Pilsgaard} and Christensen, {Mette Marie}",
year = "2018",
month = "12",
doi = "10.1097/FAD.0000000000000037",
language = "English",
volume = "313",
pages = "1211–1214",
journal = "Adverse Drug Reaction Bulletin",
issn = "0044-6394",
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Drug-induced Sialorrhoea. / Haastrup, Maija Bruun; Henriksen, Daniel Pilsgaard; Christensen, Mette Marie.

I: Adverse Drug Reaction Bulletin, Bind 313, Nr. 1, 12.2018, s. 1211–1214.

Publikation: Bidrag til tidsskriftReviewForskningpeer review

TY - JOUR

T1 - Drug-induced Sialorrhoea

AU - Haastrup, Maija Bruun

AU - Henriksen, Daniel Pilsgaard

AU - Christensen, Mette Marie

PY - 2018/12

Y1 - 2018/12

N2 - Sialorrhoea is a common adverse effect of a range of medicines, primarily clozapine. At least a third of patients treated with clozapine suffer from sialorrhoea, and the consequences of this can be socially stigmatising and lead to non-adherence. The treatment options are limited and primarily centered around muscarinic antagonism. We suggest non-pharmacological interventions followed by locally applied atropine or glycopyrrolate. If systemic treatment is necessary, amisulpride, benztropine, or terazosin may be attempted.

AB - Sialorrhoea is a common adverse effect of a range of medicines, primarily clozapine. At least a third of patients treated with clozapine suffer from sialorrhoea, and the consequences of this can be socially stigmatising and lead to non-adherence. The treatment options are limited and primarily centered around muscarinic antagonism. We suggest non-pharmacological interventions followed by locally applied atropine or glycopyrrolate. If systemic treatment is necessary, amisulpride, benztropine, or terazosin may be attempted.

U2 - 10.1097/FAD.0000000000000037

DO - 10.1097/FAD.0000000000000037

M3 - Review

VL - 313

SP - 1211

EP - 1214

JO - Adverse Drug Reaction Bulletin

JF - Adverse Drug Reaction Bulletin

SN - 0044-6394

IS - 1

ER -