Drinking frequency, mediating biomarkers, and risk of myocardial infarction in women and men

Kenneth J Mukamal, Majken K Jensen, Morten Grønbaek, Meir J Stampfer, JoAnn E Manson, Tobias Pischon, Eric B Rimm

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Udgivelsesdato: 2005-Sep-6
OriginalsprogEngelsk
TidsskriftCirculation
Vol/bind112
Udgave nummer10
Sider (fra-til)1406-13
Antal sider7
ISSN0009-7322
DOI
StatusUdgivet - 6. sep. 2005
Udgivet eksterntJa

Fingeraftryk

Drinking
Alcohols
HDL Cholesterol
Health
Insulin Resistance
Case-Control Studies
Smoking
Nurses

Citer dette

Mukamal, K. J., Jensen, M. K., Grønbaek, M., Stampfer, M. J., Manson, J. E., Pischon, T., & Rimm, E. B. (2005). Drinking frequency, mediating biomarkers, and risk of myocardial infarction in women and men. Circulation, 112(10), 1406-13. https://doi.org/10.1161/CIRCULATIONAHA.105.537704
Mukamal, Kenneth J ; Jensen, Majken K ; Grønbaek, Morten ; Stampfer, Meir J ; Manson, JoAnn E ; Pischon, Tobias ; Rimm, Eric B. / Drinking frequency, mediating biomarkers, and risk of myocardial infarction in women and men. I: Circulation. 2005 ; Bind 112, Nr. 10. s. 1406-13.
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title = "Drinking frequency, mediating biomarkers, and risk of myocardial infarction in women and men",
abstract = "BACKGROUND: The associations of drinking frequency and quantity with risk of myocardial infarction have not been studied among women, and the degree to which specific risk factors mediate the inverse association of drinking frequency with risk of myocardial infarction is uncertain. METHODS AND RESULTS: We conducted nested case-control studies of 32,826 women enrolled in the Nurses Health Study followed up from 1990 to 1998 and 18,225 men enrolled in the Health Professionals Follow-Up Study followed up from 1994 to 2000. A total of 249 women and 266 men with incident myocardial infarction were matched on age, smoking, and date of entry to 498 female and 532 male control participants. We determined the risk of myocardial infarction related to frequency and quantity of alcohol intake and the change in risk before and after adjustment for putative cardiovascular risk factors. Among both women and men, drinking frequency tended to be associated with lower risk of myocardial infarction, with the lowest risks among those who drank 3 to 7 days per week. Further adjustment for levels of high-density lipoprotein cholesterol, hemoglobin A(1c), and fibrinogen attenuated 75{\%} of the association of frequent drinking with risk among women and fully attenuated the association among men. CONCLUSIONS: Alcohol intake at least 3 to 4 days per week is associated with a lower risk of myocardial infarction among women and men, an association apparently attributable to the relationship of alcohol with HDL cholesterol, fibrinogen, and hemoglobin A(1c). Because the effects of alcohol on HDL cholesterol, fibrinogen, and insulin sensitivity have been confirmed in randomized trials, our findings support the hypothesis that the inverse relation of alcohol use and myocardial infarction is causal.",
author = "Mukamal, {Kenneth J} and Jensen, {Majken K} and Morten Gr{\o}nbaek and Stampfer, {Meir J} and Manson, {JoAnn E} and Tobias Pischon and Rimm, {Eric B}",
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language = "English",
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Mukamal, KJ, Jensen, MK, Grønbaek, M, Stampfer, MJ, Manson, JE, Pischon, T & Rimm, EB 2005, 'Drinking frequency, mediating biomarkers, and risk of myocardial infarction in women and men', Circulation, bind 112, nr. 10, s. 1406-13. https://doi.org/10.1161/CIRCULATIONAHA.105.537704

Drinking frequency, mediating biomarkers, and risk of myocardial infarction in women and men. / Mukamal, Kenneth J; Jensen, Majken K; Grønbaek, Morten; Stampfer, Meir J; Manson, JoAnn E; Pischon, Tobias; Rimm, Eric B.

I: Circulation, Bind 112, Nr. 10, 06.09.2005, s. 1406-13.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Drinking frequency, mediating biomarkers, and risk of myocardial infarction in women and men

AU - Mukamal, Kenneth J

AU - Jensen, Majken K

AU - Grønbaek, Morten

AU - Stampfer, Meir J

AU - Manson, JoAnn E

AU - Pischon, Tobias

AU - Rimm, Eric B

PY - 2005/9/6

Y1 - 2005/9/6

N2 - BACKGROUND: The associations of drinking frequency and quantity with risk of myocardial infarction have not been studied among women, and the degree to which specific risk factors mediate the inverse association of drinking frequency with risk of myocardial infarction is uncertain. METHODS AND RESULTS: We conducted nested case-control studies of 32,826 women enrolled in the Nurses Health Study followed up from 1990 to 1998 and 18,225 men enrolled in the Health Professionals Follow-Up Study followed up from 1994 to 2000. A total of 249 women and 266 men with incident myocardial infarction were matched on age, smoking, and date of entry to 498 female and 532 male control participants. We determined the risk of myocardial infarction related to frequency and quantity of alcohol intake and the change in risk before and after adjustment for putative cardiovascular risk factors. Among both women and men, drinking frequency tended to be associated with lower risk of myocardial infarction, with the lowest risks among those who drank 3 to 7 days per week. Further adjustment for levels of high-density lipoprotein cholesterol, hemoglobin A(1c), and fibrinogen attenuated 75% of the association of frequent drinking with risk among women and fully attenuated the association among men. CONCLUSIONS: Alcohol intake at least 3 to 4 days per week is associated with a lower risk of myocardial infarction among women and men, an association apparently attributable to the relationship of alcohol with HDL cholesterol, fibrinogen, and hemoglobin A(1c). Because the effects of alcohol on HDL cholesterol, fibrinogen, and insulin sensitivity have been confirmed in randomized trials, our findings support the hypothesis that the inverse relation of alcohol use and myocardial infarction is causal.

AB - BACKGROUND: The associations of drinking frequency and quantity with risk of myocardial infarction have not been studied among women, and the degree to which specific risk factors mediate the inverse association of drinking frequency with risk of myocardial infarction is uncertain. METHODS AND RESULTS: We conducted nested case-control studies of 32,826 women enrolled in the Nurses Health Study followed up from 1990 to 1998 and 18,225 men enrolled in the Health Professionals Follow-Up Study followed up from 1994 to 2000. A total of 249 women and 266 men with incident myocardial infarction were matched on age, smoking, and date of entry to 498 female and 532 male control participants. We determined the risk of myocardial infarction related to frequency and quantity of alcohol intake and the change in risk before and after adjustment for putative cardiovascular risk factors. Among both women and men, drinking frequency tended to be associated with lower risk of myocardial infarction, with the lowest risks among those who drank 3 to 7 days per week. Further adjustment for levels of high-density lipoprotein cholesterol, hemoglobin A(1c), and fibrinogen attenuated 75% of the association of frequent drinking with risk among women and fully attenuated the association among men. CONCLUSIONS: Alcohol intake at least 3 to 4 days per week is associated with a lower risk of myocardial infarction among women and men, an association apparently attributable to the relationship of alcohol with HDL cholesterol, fibrinogen, and hemoglobin A(1c). Because the effects of alcohol on HDL cholesterol, fibrinogen, and insulin sensitivity have been confirmed in randomized trials, our findings support the hypothesis that the inverse relation of alcohol use and myocardial infarction is causal.

U2 - 10.1161/CIRCULATIONAHA.105.537704

DO - 10.1161/CIRCULATIONAHA.105.537704

M3 - Journal article

C2 - 16129796

VL - 112

SP - 1406

EP - 1413

JO - Circulation

JF - Circulation

SN - 0009-7322

IS - 10

ER -