Dopamine release in ventral striatum during Iowa Gambling Task performance is associated with increased excitement levels in pathological gambling.

Jakob Linnet, Arne Møller, Ericka Peterson, Albert Gjedde, Doris Doudet

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Aims Gambling excitement is believed to be associated with biological measures of pathological gambling. Here, we
tested the hypothesis that dopamine release would be associated with increased excitement levels in Pathological
Gamblers compared with Healthy Controls. Design Pathological Gamblers and Healthy Controlswere experimentally
compared in a non-gambling (baseline) and gambling condition. Measurements We used Positron Emission Tomography
(PET) with the tracer raclopride to measure dopamine D 2/3 receptor availability in the ventral striatum during
a non-gambling and gambling condition of the Iowa GamblingTask (IGT). After each condition participants rated their
excitement level. Setting Laboratory experiment. Participants 18 Pathological Gamblers and 16 Healthy Controls.
Findings Pathological Gamblers with dopamine release in the ventral striatum had significantly higher excitement
levels than Healthy Controls despite lower IGT performance. No differences in excitement levels and IGT performance
were found between Pathological Gamblers and Healthy Controls without dopamine release. Pathological Gamblers
showed a significant correlation between dopamine release and excitement level, while no such interaction was
found in Healthy Controls. Conclusions In pathological gamblers dopamine release in the ventral striatum appears
to be associated with increased excitement levels despite lower IGT performance. The results might suggest
a ‘double deficit’ function of dopamine in pathological gambling, where dopamine release reinforces maladaptive
gambling through increasing excitement levels, reducing inhibition of risky decisions, or a combination of both. These
findings may have implications for the understanding of dopamine in pathological gambling and other forms of
addiction.
OriginalsprogEngelsk
TidsskriftAddiction
Vol/bind106
Udgave nummer2
Sider (fra-til)383-390
Antal sider8
ISSN0965-2140
StatusUdgivet - 11. feb. 2011
Udgivet eksterntJa

Fingeraftryk

Gambling
Raclopride

Citer dette

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title = "Dopamine release in ventral striatum during Iowa Gambling Task performance is associated with increased excitement levels in pathological gambling.",
abstract = "Aims Gambling excitement is believed to be associated with biological measures of pathological gambling. Here, wetested the hypothesis that dopamine release would be associated with increased excitement levels in PathologicalGamblers compared with Healthy Controls. Design Pathological Gamblers and Healthy Controlswere experimentallycompared in a non-gambling (baseline) and gambling condition. Measurements We used Positron Emission Tomography(PET) with the tracer raclopride to measure dopamine D 2/3 receptor availability in the ventral striatum duringa non-gambling and gambling condition of the Iowa GamblingTask (IGT). After each condition participants rated theirexcitement level. Setting Laboratory experiment. Participants 18 Pathological Gamblers and 16 Healthy Controls.Findings Pathological Gamblers with dopamine release in the ventral striatum had significantly higher excitementlevels than Healthy Controls despite lower IGT performance. No differences in excitement levels and IGT performancewere found between Pathological Gamblers and Healthy Controls without dopamine release. Pathological Gamblersshowed a significant correlation between dopamine release and excitement level, while no such interaction wasfound in Healthy Controls. Conclusions In pathological gamblers dopamine release in the ventral striatum appearsto be associated with increased excitement levels despite lower IGT performance. The results might suggesta ‘double deficit’ function of dopamine in pathological gambling, where dopamine release reinforces maladaptivegambling through increasing excitement levels, reducing inhibition of risky decisions, or a combination of both. Thesefindings may have implications for the understanding of dopamine in pathological gambling and other forms ofaddiction.",
author = "Jakob Linnet and Arne M{\o}ller and Ericka Peterson and Albert Gjedde and Doris Doudet",
year = "2011",
month = "2",
day = "11",
language = "English",
volume = "106",
pages = "383--390",
journal = "Addiction",
issn = "0965-2140",
publisher = "Wiley-Blackwell",
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Dopamine release in ventral striatum during Iowa Gambling Task performance is associated with increased excitement levels in pathological gambling. / Linnet, Jakob; Møller, Arne; Peterson, Ericka; Gjedde, Albert; Doudet, Doris.

I: Addiction, Bind 106, Nr. 2, 11.02.2011, s. 383-390.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Dopamine release in ventral striatum during Iowa Gambling Task performance is associated with increased excitement levels in pathological gambling.

AU - Linnet, Jakob

AU - Møller, Arne

AU - Peterson, Ericka

AU - Gjedde, Albert

AU - Doudet, Doris

PY - 2011/2/11

Y1 - 2011/2/11

N2 - Aims Gambling excitement is believed to be associated with biological measures of pathological gambling. Here, wetested the hypothesis that dopamine release would be associated with increased excitement levels in PathologicalGamblers compared with Healthy Controls. Design Pathological Gamblers and Healthy Controlswere experimentallycompared in a non-gambling (baseline) and gambling condition. Measurements We used Positron Emission Tomography(PET) with the tracer raclopride to measure dopamine D 2/3 receptor availability in the ventral striatum duringa non-gambling and gambling condition of the Iowa GamblingTask (IGT). After each condition participants rated theirexcitement level. Setting Laboratory experiment. Participants 18 Pathological Gamblers and 16 Healthy Controls.Findings Pathological Gamblers with dopamine release in the ventral striatum had significantly higher excitementlevels than Healthy Controls despite lower IGT performance. No differences in excitement levels and IGT performancewere found between Pathological Gamblers and Healthy Controls without dopamine release. Pathological Gamblersshowed a significant correlation between dopamine release and excitement level, while no such interaction wasfound in Healthy Controls. Conclusions In pathological gamblers dopamine release in the ventral striatum appearsto be associated with increased excitement levels despite lower IGT performance. The results might suggesta ‘double deficit’ function of dopamine in pathological gambling, where dopamine release reinforces maladaptivegambling through increasing excitement levels, reducing inhibition of risky decisions, or a combination of both. Thesefindings may have implications for the understanding of dopamine in pathological gambling and other forms ofaddiction.

AB - Aims Gambling excitement is believed to be associated with biological measures of pathological gambling. Here, wetested the hypothesis that dopamine release would be associated with increased excitement levels in PathologicalGamblers compared with Healthy Controls. Design Pathological Gamblers and Healthy Controlswere experimentallycompared in a non-gambling (baseline) and gambling condition. Measurements We used Positron Emission Tomography(PET) with the tracer raclopride to measure dopamine D 2/3 receptor availability in the ventral striatum duringa non-gambling and gambling condition of the Iowa GamblingTask (IGT). After each condition participants rated theirexcitement level. Setting Laboratory experiment. Participants 18 Pathological Gamblers and 16 Healthy Controls.Findings Pathological Gamblers with dopamine release in the ventral striatum had significantly higher excitementlevels than Healthy Controls despite lower IGT performance. No differences in excitement levels and IGT performancewere found between Pathological Gamblers and Healthy Controls without dopamine release. Pathological Gamblersshowed a significant correlation between dopamine release and excitement level, while no such interaction wasfound in Healthy Controls. Conclusions In pathological gamblers dopamine release in the ventral striatum appearsto be associated with increased excitement levels despite lower IGT performance. The results might suggesta ‘double deficit’ function of dopamine in pathological gambling, where dopamine release reinforces maladaptivegambling through increasing excitement levels, reducing inhibition of risky decisions, or a combination of both. Thesefindings may have implications for the understanding of dopamine in pathological gambling and other forms ofaddiction.

M3 - Journal article

VL - 106

SP - 383

EP - 390

JO - Addiction

JF - Addiction

SN - 0965-2140

IS - 2

ER -