Abstrakt
Calcineurin inhibitors have markedly reduced acute rejection rates in renal transplantation, thus significantly improved short-term outcome. The beneficial effects are, however, tampered by acute and chronic nephrotoxicity leading to interstitial fibrosis and tubular atrophy, which impairs long-term allograft survival. The mineralocorticoid hormone aldosterone induces fibrosis in numerous organs, including the kidney. Evidence from animal models suggests a beneficial effect of aldosterone antagonism in reducing calcineurin inhibitor-induced nephrotoxicity. This review summarizes current evidence of mineralocorticoid receptor antagonism in animal models of calcineurin inhibitor-induced nephrotoxicity and the results from studies of mineralocorticoid antagonism in renal transplant patients.
Originalsprog | Engelsk |
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Artikelnummer | 210 |
Tidsskrift | Frontiers in Medicine |
Vol/bind | 4 |
Udgave nummer | NOV |
Antal sider | 8 |
ISSN | 2296-858X |
DOI | |
Status | Udgivet - 1. jan. 2017 |