Does caffeine and alcohol intake before pregnancy predict the occurrence of spontaneous abortion?

J S Tolstrup, S. K. Kjær, C Munk, L B Madsen, B Ottesen, T Bergholt, M Grønbaek

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Udgivelsesdato: 2003-Dec
OriginalsprogEngelsk
TidsskriftHuman Reproduction
Vol/bind18
Udgave nummer12
Sider (fra-til)2704-10
Antal sider6
ISSN0268-1161
StatusUdgivet - 1. dec. 2003

Fingeraftryk

Spontaneous Abortion
Alcohols
Fetal Viability
Alcohol Drinking
Case-Control Studies
Public Health
Logistic Models
Population

Citer dette

Tolstrup, J S ; Kjær, S. K. ; Munk, C ; Madsen, L B ; Ottesen, B ; Bergholt, T ; Grønbaek, M. / Does caffeine and alcohol intake before pregnancy predict the occurrence of spontaneous abortion?. I: Human Reproduction. 2003 ; Bind 18, Nr. 12. s. 2704-10.
@article{239052b0e0bb11dd9909000ea68e967b,
title = "Does caffeine and alcohol intake before pregnancy predict the occurrence of spontaneous abortion?",
abstract = "BACKGROUND: Consumption of caffeine and alcohol is suspected to affect pregnancy outcome. Use of both stimulants is widespread and even minor effects on fetal viability are of public health interest. METHODS: We performed a nested case-control study using prospective data from a population-based cohort comprising 11088 women aged 20-29 years. From this cohort, women who experienced either a spontaneous abortion (n = 303) or who gave birth (n = 1381) during follow-up [mean time: 2.1 years (range: 1.6-3.4)] were selected. Associations between self-reported exposures to caffeine and/or alcohol at enrolment and spontaneous abortion were analysed by means of logistic regression. RESULTS: Compared with women with a pre-pregnancy intake of <75 mg caffeine per day, the adjusted odds ratio (95{\%} confidence interval) for spontaneous abortion was 1.26 (0.77-2.06), 1.45 (0.87-2.41), 1.44 (0.87-2.37) and 1.72 (1.00-2.96) for a pre-pregnancy intake on 75-300, 301-500, 501-900 and >900 mg caffeine per day respectively (P = 0.05 for trend). A pre-pregnancy intake of alcohol was not a predictor for spontaneous abortion. CONCLUSIONS: A high intake of caffeine prior to pregnancy seems to be associated with an increased risk of spontaneous abortion, whereas a low-to-moderate alcohol intake does not influence the risk.",
keywords = "Abortion, Spontaneous, Adult, Caffeine, Case-Control Studies, Cohort Studies, Ethanol, Female, Humans, Logistic Models, Odds Ratio, Preconception Care, Pregnancy, Prospective Studies",
author = "Tolstrup, {J S} and Kj{\ae}r, {S. K.} and C Munk and Madsen, {L B} and B Ottesen and T Bergholt and M Gr{\o}nbaek",
year = "2003",
month = "12",
day = "1",
language = "English",
volume = "18",
pages = "2704--10",
journal = "Human Reproduction",
issn = "0268-1161",
publisher = "Heinemann",
number = "12",

}

Tolstrup, JS, Kjær, SK, Munk, C, Madsen, LB, Ottesen, B, Bergholt, T & Grønbaek, M 2003, 'Does caffeine and alcohol intake before pregnancy predict the occurrence of spontaneous abortion?', Human Reproduction, bind 18, nr. 12, s. 2704-10.

Does caffeine and alcohol intake before pregnancy predict the occurrence of spontaneous abortion? / Tolstrup, J S; Kjær, S. K.; Munk, C; Madsen, L B; Ottesen, B; Bergholt, T; Grønbaek, M.

I: Human Reproduction, Bind 18, Nr. 12, 01.12.2003, s. 2704-10.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Does caffeine and alcohol intake before pregnancy predict the occurrence of spontaneous abortion?

AU - Tolstrup, J S

AU - Kjær, S. K.

AU - Munk, C

AU - Madsen, L B

AU - Ottesen, B

AU - Bergholt, T

AU - Grønbaek, M

PY - 2003/12/1

Y1 - 2003/12/1

N2 - BACKGROUND: Consumption of caffeine and alcohol is suspected to affect pregnancy outcome. Use of both stimulants is widespread and even minor effects on fetal viability are of public health interest. METHODS: We performed a nested case-control study using prospective data from a population-based cohort comprising 11088 women aged 20-29 years. From this cohort, women who experienced either a spontaneous abortion (n = 303) or who gave birth (n = 1381) during follow-up [mean time: 2.1 years (range: 1.6-3.4)] were selected. Associations between self-reported exposures to caffeine and/or alcohol at enrolment and spontaneous abortion were analysed by means of logistic regression. RESULTS: Compared with women with a pre-pregnancy intake of <75 mg caffeine per day, the adjusted odds ratio (95% confidence interval) for spontaneous abortion was 1.26 (0.77-2.06), 1.45 (0.87-2.41), 1.44 (0.87-2.37) and 1.72 (1.00-2.96) for a pre-pregnancy intake on 75-300, 301-500, 501-900 and >900 mg caffeine per day respectively (P = 0.05 for trend). A pre-pregnancy intake of alcohol was not a predictor for spontaneous abortion. CONCLUSIONS: A high intake of caffeine prior to pregnancy seems to be associated with an increased risk of spontaneous abortion, whereas a low-to-moderate alcohol intake does not influence the risk.

AB - BACKGROUND: Consumption of caffeine and alcohol is suspected to affect pregnancy outcome. Use of both stimulants is widespread and even minor effects on fetal viability are of public health interest. METHODS: We performed a nested case-control study using prospective data from a population-based cohort comprising 11088 women aged 20-29 years. From this cohort, women who experienced either a spontaneous abortion (n = 303) or who gave birth (n = 1381) during follow-up [mean time: 2.1 years (range: 1.6-3.4)] were selected. Associations between self-reported exposures to caffeine and/or alcohol at enrolment and spontaneous abortion were analysed by means of logistic regression. RESULTS: Compared with women with a pre-pregnancy intake of <75 mg caffeine per day, the adjusted odds ratio (95% confidence interval) for spontaneous abortion was 1.26 (0.77-2.06), 1.45 (0.87-2.41), 1.44 (0.87-2.37) and 1.72 (1.00-2.96) for a pre-pregnancy intake on 75-300, 301-500, 501-900 and >900 mg caffeine per day respectively (P = 0.05 for trend). A pre-pregnancy intake of alcohol was not a predictor for spontaneous abortion. CONCLUSIONS: A high intake of caffeine prior to pregnancy seems to be associated with an increased risk of spontaneous abortion, whereas a low-to-moderate alcohol intake does not influence the risk.

KW - Abortion, Spontaneous

KW - Adult

KW - Caffeine

KW - Case-Control Studies

KW - Cohort Studies

KW - Ethanol

KW - Female

KW - Humans

KW - Logistic Models

KW - Odds Ratio

KW - Preconception Care

KW - Pregnancy

KW - Prospective Studies

M3 - Journal article

VL - 18

SP - 2704

EP - 2710

JO - Human Reproduction

JF - Human Reproduction

SN - 0268-1161

IS - 12

ER -

Tolstrup JS, Kjær SK, Munk C, Madsen LB, Ottesen B, Bergholt T et al. Does caffeine and alcohol intake before pregnancy predict the occurrence of spontaneous abortion? Human Reproduction. 2003 dec 1;18(12):2704-10.