Do Mandibular Advancement Devices Influence Patients' Snoring and Obstructive Sleep Apnea? A Cone-Beam Computed Tomography Analysis of the Upper Airway Volume

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

PURPOSE: The upper airway volume is central to the development and treatment of snoring and obstructive sleep apnea, and mandibular advancement devices (MADs) have increasingly been used as an effective alternative to continuous positive airway pressure for these 2 conditions. We investigated the changes in breathing patterns and upper airway volume parameters measured on cone-beam computed tomography (CBCT) scans of patients with and without the use of custom-made MADs.

MATERIALS AND METHODS: We performed a prospective study at the Department of Oral and Maxillofacial Surgery, Odense University Hospital, on consecutively treated patients. CBCT scans were performed with and without the MAD to measure the changes in the upper airway volume. The patients underwent diagnostic cardiorespiratory monitoring before and after 3 months of MAD therapy. Measurements with and without MAD were compared using Student's t test and the Wilcoxon signed rank test, and mixed-model analyses were performed adjusting for sleep apnea severity, type 2 diabetes, body mass index, gender, and age.

RESULTS: A total of 44 patients (31 men and 13 women, age 50 ± 13 years, body mass index 31 ± 5.6 kg/m(2)) completed the trial. MAD therapy was associated with an increase in the total upper airway volume from 22.9 ± 8.7 cm(3) before treatment to 26.7 ± 10.7 cm(3) after treatment (P < .001). MAD therapy reduced the apnea-hypopnea index (AHI) from 15.8 ± 17.4 events/hour before treatment to 6.2 ± 9.8 events/hour after treatment (P < .001).

CONCLUSION: The results of the present study indicate that MAD therapy appears to produce significant changes in the upper airway volume that correlate with a decrease in the AHI.

OriginalsprogEngelsk
TidsskriftJournal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons
Vol/bind73
Udgave nummer9
Sider (fra-til)1816-26
Antal sider11
ISSN0278-2391
DOI
StatusUdgivet - sep. 2015

Fingeraftryk

Mandibular Advancement
Snoring
Equipment and Supplies
Body Mass Index
Continuous Positive Airway Pressure
Nonparametric Statistics
Type 2 Diabetes Mellitus
Respiration
Prospective Studies

Citer dette

@article{013d8c1983594202ac62e1e92bb84901,
title = "Do Mandibular Advancement Devices Influence Patients' Snoring and Obstructive Sleep Apnea?: A Cone-Beam Computed Tomography Analysis of the Upper Airway Volume",
abstract = "PURPOSE: The upper airway volume is central to the development and treatment of snoring and obstructive sleep apnea, and mandibular advancement devices (MADs) have increasingly been used as an effective alternative to continuous positive airway pressure for these 2 conditions. We investigated the changes in breathing patterns and upper airway volume parameters measured on cone-beam computed tomography (CBCT) scans of patients with and without the use of custom-made MADs.MATERIALS AND METHODS: We performed a prospective study at the Department of Oral and Maxillofacial Surgery, Odense University Hospital, on consecutively treated patients. CBCT scans were performed with and without the MAD to measure the changes in the upper airway volume. The patients underwent diagnostic cardiorespiratory monitoring before and after 3 months of MAD therapy. Measurements with and without MAD were compared using Student's t test and the Wilcoxon signed rank test, and mixed-model analyses were performed adjusting for sleep apnea severity, type 2 diabetes, body mass index, gender, and age.RESULTS: A total of 44 patients (31 men and 13 women, age 50 ± 13 years, body mass index 31 ± 5.6 kg/m(2)) completed the trial. MAD therapy was associated with an increase in the total upper airway volume from 22.9 ± 8.7 cm(3) before treatment to 26.7 ± 10.7 cm(3) after treatment (P < .001). MAD therapy reduced the apnea-hypopnea index (AHI) from 15.8 ± 17.4 events/hour before treatment to 6.2 ± 9.8 events/hour after treatment (P < .001).CONCLUSION: The results of the present study indicate that MAD therapy appears to produce significant changes in the upper airway volume that correlate with a decrease in the AHI.",
keywords = "Cone-Beam Computed Tomography, Humans, Lung Volume Measurements, Mandibular Advancement, Prospective Studies, Sleep Apnea, Obstructive, Snoring",
author = "Lillian Marcussen and Henriksen, {Jan Erik} and Torben Thygesen",
note = "Copyright {\circledC} 2015 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.",
year = "2015",
month = "9",
doi = "10.1016/j.joms.2015.02.023",
language = "English",
volume = "73",
pages = "1816--26",
journal = "Journal of Oral and Maxillofacial Surgery",
issn = "0278-2391",
publisher = "W.B.Saunders Co.",
number = "9",

}

TY - JOUR

T1 - Do Mandibular Advancement Devices Influence Patients' Snoring and Obstructive Sleep Apnea?

T2 - A Cone-Beam Computed Tomography Analysis of the Upper Airway Volume

AU - Marcussen, Lillian

AU - Henriksen, Jan Erik

AU - Thygesen, Torben

N1 - Copyright © 2015 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.

PY - 2015/9

Y1 - 2015/9

N2 - PURPOSE: The upper airway volume is central to the development and treatment of snoring and obstructive sleep apnea, and mandibular advancement devices (MADs) have increasingly been used as an effective alternative to continuous positive airway pressure for these 2 conditions. We investigated the changes in breathing patterns and upper airway volume parameters measured on cone-beam computed tomography (CBCT) scans of patients with and without the use of custom-made MADs.MATERIALS AND METHODS: We performed a prospective study at the Department of Oral and Maxillofacial Surgery, Odense University Hospital, on consecutively treated patients. CBCT scans were performed with and without the MAD to measure the changes in the upper airway volume. The patients underwent diagnostic cardiorespiratory monitoring before and after 3 months of MAD therapy. Measurements with and without MAD were compared using Student's t test and the Wilcoxon signed rank test, and mixed-model analyses were performed adjusting for sleep apnea severity, type 2 diabetes, body mass index, gender, and age.RESULTS: A total of 44 patients (31 men and 13 women, age 50 ± 13 years, body mass index 31 ± 5.6 kg/m(2)) completed the trial. MAD therapy was associated with an increase in the total upper airway volume from 22.9 ± 8.7 cm(3) before treatment to 26.7 ± 10.7 cm(3) after treatment (P < .001). MAD therapy reduced the apnea-hypopnea index (AHI) from 15.8 ± 17.4 events/hour before treatment to 6.2 ± 9.8 events/hour after treatment (P < .001).CONCLUSION: The results of the present study indicate that MAD therapy appears to produce significant changes in the upper airway volume that correlate with a decrease in the AHI.

AB - PURPOSE: The upper airway volume is central to the development and treatment of snoring and obstructive sleep apnea, and mandibular advancement devices (MADs) have increasingly been used as an effective alternative to continuous positive airway pressure for these 2 conditions. We investigated the changes in breathing patterns and upper airway volume parameters measured on cone-beam computed tomography (CBCT) scans of patients with and without the use of custom-made MADs.MATERIALS AND METHODS: We performed a prospective study at the Department of Oral and Maxillofacial Surgery, Odense University Hospital, on consecutively treated patients. CBCT scans were performed with and without the MAD to measure the changes in the upper airway volume. The patients underwent diagnostic cardiorespiratory monitoring before and after 3 months of MAD therapy. Measurements with and without MAD were compared using Student's t test and the Wilcoxon signed rank test, and mixed-model analyses were performed adjusting for sleep apnea severity, type 2 diabetes, body mass index, gender, and age.RESULTS: A total of 44 patients (31 men and 13 women, age 50 ± 13 years, body mass index 31 ± 5.6 kg/m(2)) completed the trial. MAD therapy was associated with an increase in the total upper airway volume from 22.9 ± 8.7 cm(3) before treatment to 26.7 ± 10.7 cm(3) after treatment (P < .001). MAD therapy reduced the apnea-hypopnea index (AHI) from 15.8 ± 17.4 events/hour before treatment to 6.2 ± 9.8 events/hour after treatment (P < .001).CONCLUSION: The results of the present study indicate that MAD therapy appears to produce significant changes in the upper airway volume that correlate with a decrease in the AHI.

KW - Cone-Beam Computed Tomography

KW - Humans

KW - Lung Volume Measurements

KW - Mandibular Advancement

KW - Prospective Studies

KW - Sleep Apnea, Obstructive

KW - Snoring

U2 - 10.1016/j.joms.2015.02.023

DO - 10.1016/j.joms.2015.02.023

M3 - Journal article

C2 - 25970514

VL - 73

SP - 1816

EP - 1826

JO - Journal of Oral and Maxillofacial Surgery

JF - Journal of Oral and Maxillofacial Surgery

SN - 0278-2391

IS - 9

ER -