DNA-Templated Synthesis Optimization

Bjarke N. Hansen, Kim Skak Larsen, Daniel Merkle, Alexei Mihalchuk

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Abstrakt

In chemistry, synthesis is the process in which a target compound is produced in a step-wise manner from given base compounds. A recent, promising approach for carrying out these reactions is DNA-templated synthesis, since, as opposed to more traditional methods, this approach leads to a much higher effective molarity and makes much desired one-pot synthesis possible. With this method, compounds are tagged with DNA sequences and reactions can be controlled by bringing two compounds together via their tags. This leads to new cost optimization problems of minimizing the number of different tags or strands to be used under various conditions. We identify relevant optimization criteria, provide the first computational approach to automatically inferring DNA-templated programs, and obtain optimal and near-optimal results.
OriginalsprogEngelsk
Titel23rd International Conference on DNA Computing and Molecular Programming
ForlagSpringer
Publikationsdato2017
Sider17-32
ISBN (Trykt)978-3-319-66798-0
ISBN (Elektronisk)978-3-319-66799-7
DOI
StatusUdgivet - 2017
Begivenhed23rd International Conference on DNA Computing and Molecular Programming - Austin, USA
Varighed: 24. sep. 201728. sep. 2017
Konferencens nummer: 23

Konference

Konference23rd International Conference on DNA Computing and Molecular Programming
Nummer23
LandUSA
ByAustin
Periode24/09/201728/09/2017
NavnLecture Notes in Computer Science
Vol/bind10467
ISSN0302-9743

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Citationsformater

Hansen, B. N., Larsen, K. S., Merkle, D., & Mihalchuk, A. (2017). DNA-Templated Synthesis Optimization. I 23rd International Conference on DNA Computing and Molecular Programming (s. 17-32). Springer. Lecture Notes in Computer Science, Bind. 10467 https://doi.org/10.1007/978-3-319-66799-7_2