Resumé

Objectives: The overall distribution of disease courses in multiple sclerosis (MS) is well established, but little is known about the distribution among familial MS cases. We examine the frequency of the different MS courses among familial and sporadic MS cases and determine whether MS cases within the same family had the same age at diagnosis and have experienced the same disease course. Materials and methods: This is a nationwide register study, based on data from the Danish MS Registry, the Danish Civil Registration System, and the Danish National Patient Registry. The main variables are MS diagnosis, MS course, and first-degree relatives with MS The statistical analyses were carried out using logistic regression analysis, Kappa coefficient, and intraclass correlations coefficient. Results: In total, 7402 MS cases were included in the study, of which 531 have an affected first-degree relatives, and 6871 are sporadic. We found that relapsing-remitting MS including secondary progressive MS was more common among familial MS cases than among sporadic MS cases (Odds ratio = 1.64, 95% CI: 1.20-2.24, P = 0.002). We subsequently analyzed data on 133 MS families and found that MS courses correlate between the first and the second MS case diagnosed, while age at diagnosis does not. Conclusion: Familial MS cases are more likely to have relapsing-remitting MS than a progressive course compared to sporadic MS cases. Secondly, we find that within MS families, first-degree relatives are likely to have the same MS course, but we do not find that they are diagnosed at the same age.

OriginalsprogEngelsk
TidsskriftActa Neurologica Scandinavica
Vol/bind139
Udgave nummer3
Sider (fra-til)231-237
ISSN0001-6314
DOI
StatusUdgivet - mar. 2019

Fingeraftryk

Relapsing-Remitting Multiple Sclerosis
Registries
Chronic Progressive Multiple Sclerosis
Logistic Models
Odds Ratio
Regression Analysis

Citer dette

@article{36b9da7220854e04a7c9159226491683,
title = "Distribution of disease courses in familial vs sporadic multiple sclerosis",
abstract = "Objectives: The overall distribution of disease courses in multiple sclerosis (MS) is well established, but little is known about the distribution among familial MS cases. We examine the frequency of the different MS courses among familial and sporadic MS cases and determine whether MS cases within the same family had the same age at diagnosis and have experienced the same disease course. Materials and methods: This is a nationwide register study, based on data from the Danish MS Registry, the Danish Civil Registration System, and the Danish National Patient Registry. The main variables are MS diagnosis, MS course, and first-degree relatives with MS The statistical analyses were carried out using logistic regression analysis, Kappa coefficient, and intraclass correlations coefficient. Results: In total, 7402 MS cases were included in the study, of which 531 have an affected first-degree relatives, and 6871 are sporadic. We found that relapsing-remitting MS including secondary progressive MS was more common among familial MS cases than among sporadic MS cases (Odds ratio = 1.64, 95{\%} CI: 1.20-2.24, P = 0.002). We subsequently analyzed data on 133 MS families and found that MS courses correlate between the first and the second MS case diagnosed, while age at diagnosis does not. Conclusion: Familial MS cases are more likely to have relapsing-remitting MS than a progressive course compared to sporadic MS cases. Secondly, we find that within MS families, first-degree relatives are likely to have the same MS course, but we do not find that they are diagnosed at the same age.",
keywords = "MS courses, familial MS, multiple sclerosis, progressive MS, relapse-remitting MS, Genetic Predisposition to Disease, Humans, Middle Aged, Male, Disease Progression, Denmark/epidemiology, Adult, Female, Registries, Multiple Sclerosis/epidemiology",
author = "Maria Steenhof and Nielsen, {Nete Munk} and Egon Stenager and Kirsten Kyvik and S{\"o}ren M{\"o}ller and Hertz, {Jens Michael}",
note = "{\circledC} 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.",
year = "2019",
month = "3",
doi = "10.1111/ane.13044",
language = "English",
volume = "139",
pages = "231--237",
journal = "Acta Neurologica Scandinavica",
issn = "0001-6314",
publisher = "Wiley-Blackwell Munksgaard",
number = "3",

}

Distribution of disease courses in familial vs sporadic multiple sclerosis. / Steenhof, Maria; Nielsen, Nete Munk; Stenager, Egon; Kyvik, Kirsten; Möller, Sören; Hertz, Jens Michael.

I: Acta Neurologica Scandinavica, Bind 139, Nr. 3, 03.2019, s. 231-237.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Distribution of disease courses in familial vs sporadic multiple sclerosis

AU - Steenhof, Maria

AU - Nielsen, Nete Munk

AU - Stenager, Egon

AU - Kyvik, Kirsten

AU - Möller, Sören

AU - Hertz, Jens Michael

N1 - © 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

PY - 2019/3

Y1 - 2019/3

N2 - Objectives: The overall distribution of disease courses in multiple sclerosis (MS) is well established, but little is known about the distribution among familial MS cases. We examine the frequency of the different MS courses among familial and sporadic MS cases and determine whether MS cases within the same family had the same age at diagnosis and have experienced the same disease course. Materials and methods: This is a nationwide register study, based on data from the Danish MS Registry, the Danish Civil Registration System, and the Danish National Patient Registry. The main variables are MS diagnosis, MS course, and first-degree relatives with MS The statistical analyses were carried out using logistic regression analysis, Kappa coefficient, and intraclass correlations coefficient. Results: In total, 7402 MS cases were included in the study, of which 531 have an affected first-degree relatives, and 6871 are sporadic. We found that relapsing-remitting MS including secondary progressive MS was more common among familial MS cases than among sporadic MS cases (Odds ratio = 1.64, 95% CI: 1.20-2.24, P = 0.002). We subsequently analyzed data on 133 MS families and found that MS courses correlate between the first and the second MS case diagnosed, while age at diagnosis does not. Conclusion: Familial MS cases are more likely to have relapsing-remitting MS than a progressive course compared to sporadic MS cases. Secondly, we find that within MS families, first-degree relatives are likely to have the same MS course, but we do not find that they are diagnosed at the same age.

AB - Objectives: The overall distribution of disease courses in multiple sclerosis (MS) is well established, but little is known about the distribution among familial MS cases. We examine the frequency of the different MS courses among familial and sporadic MS cases and determine whether MS cases within the same family had the same age at diagnosis and have experienced the same disease course. Materials and methods: This is a nationwide register study, based on data from the Danish MS Registry, the Danish Civil Registration System, and the Danish National Patient Registry. The main variables are MS diagnosis, MS course, and first-degree relatives with MS The statistical analyses were carried out using logistic regression analysis, Kappa coefficient, and intraclass correlations coefficient. Results: In total, 7402 MS cases were included in the study, of which 531 have an affected first-degree relatives, and 6871 are sporadic. We found that relapsing-remitting MS including secondary progressive MS was more common among familial MS cases than among sporadic MS cases (Odds ratio = 1.64, 95% CI: 1.20-2.24, P = 0.002). We subsequently analyzed data on 133 MS families and found that MS courses correlate between the first and the second MS case diagnosed, while age at diagnosis does not. Conclusion: Familial MS cases are more likely to have relapsing-remitting MS than a progressive course compared to sporadic MS cases. Secondly, we find that within MS families, first-degree relatives are likely to have the same MS course, but we do not find that they are diagnosed at the same age.

KW - MS courses

KW - familial MS

KW - multiple sclerosis

KW - progressive MS

KW - relapse-remitting MS

KW - Genetic Predisposition to Disease

KW - Humans

KW - Middle Aged

KW - Male

KW - Disease Progression

KW - Denmark/epidemiology

KW - Adult

KW - Female

KW - Registries

KW - Multiple Sclerosis/epidemiology

U2 - 10.1111/ane.13044

DO - 10.1111/ane.13044

M3 - Journal article

VL - 139

SP - 231

EP - 237

JO - Acta Neurologica Scandinavica

JF - Acta Neurologica Scandinavica

SN - 0001-6314

IS - 3

ER -