Distal chromosome 1q aberrations and initial response to ibrutinib in central nervous system relapsed mantle cell lymphoma

Marcus Høy Hansen*, Karen Juul-Jensen, Oriane Cédile, Stephanie Kavan, Michael Boe Møller, Jacob Haaber, Charlotte Guldborg Nyvold

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Abstrakt

Relapse involving the central nervous system (CNS) is an infrequent event in the progression of mantle cell lymphoma (MCL) with an incidence of approximately four percent. We report four cases of MCL with CNS relapse. In three of the four patients a large chromosomal copy-number alteration (CNA) of 1q was demonstrated together with TP53 mutation/deletion. These patients experienced brief response to ibrutinib, whereas a fourth patient harboring mutated ATM demonstrated a long-term effect to ibrutinib and no CNA. Although it is unclear whether chromosome 1q CNA contribute to specific phenotypes these reports may be of value as such lesions are uncommon features of MCL.

OriginalsprogEngelsk
Artikelnummer100255
TidsskriftLeukemia Research Reports
Vol/bind15
Antal sider5
ISSN2213-0489
DOI
StatusUdgivet - jan. 2021

Bibliografisk note

Funding Information:
We thank professor Mads Thomassen, Department of Clinical Genetics, Odense University Hospital, Denmark, for the assistance in relation to Next-generation sequencing. Also, we are grateful for the support provided by the foundations Grosserer Brogaard og Hustrus Mindefond, Dagmar Marshalls Fond, A. J. Andersen og hustrus Fond, and Eva og Henry Fr?nkels Mindefond.

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