TY - JOUR
T1 - Disruption of the gene regulatory programme in neurodevelopmental disorders.
AU - Griffin, Aoife
AU - Mahesh, Arun
AU - Tiwari, Vijay K.
PY - 2022/10
Y1 - 2022/10
N2 - Cortical development consists of a series of synchronised events, including fate transition of cortical progenitors, neuronal migration, specification and connectivity. It is becoming clear that gene expression programs governing these events rely on the interplay between signalling molecules, transcription factors and epigenetic mechanisms. When genetic or environmental factors disrupt expression of genes involved in important brain development processes, neurodevelopmental disorders can occur. This review aims to highlight how recent advances in technologies have helped uncover and imitate the gene regulatory mechanisms commonly disrupted in neurodevelopmental disorders.
AB - Cortical development consists of a series of synchronised events, including fate transition of cortical progenitors, neuronal migration, specification and connectivity. It is becoming clear that gene expression programs governing these events rely on the interplay between signalling molecules, transcription factors and epigenetic mechanisms. When genetic or environmental factors disrupt expression of genes involved in important brain development processes, neurodevelopmental disorders can occur. This review aims to highlight how recent advances in technologies have helped uncover and imitate the gene regulatory mechanisms commonly disrupted in neurodevelopmental disorders.
KW - Epigenesis, Genetic
KW - Humans
KW - Neurodevelopmental Disorders/genetics
KW - Neurogenesis/genetics
KW - Transcription Factors/genetics
U2 - 10.1016/j.bbagrm.2022.194860
DO - 10.1016/j.bbagrm.2022.194860
M3 - Journal article
C2 - 36007842
SN - 1874-9399
VL - 1865
JO - BBA Gene Regulatory Mechanisms
JF - BBA Gene Regulatory Mechanisms
IS - 7
M1 - 194860
ER -