Diseases in children born to mothers with preeclampsia: a population-based sibling cohort study

Chunsen Wu, Ellen Aagaard Nøhr, Bodil H Bech, Mogens Vestergaard, Janet M Catov, Jørn Olsen

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Udgivelsesdato: 2010-Sep-25
OriginalsprogEngelsk
TidsskriftAmerican Journal of Obstetrics and Gynecology
Vol/bind204
Udgave nummer12
Sider (fra-til)e1-e5
ISSN0002-9378
DOI
StatusUdgivet - feb. 2011
Udgivet eksterntJa

Fingeraftryk

Pre-Eclampsia
Siblings
Cohort Studies
Mothers
Population
Metabolic Diseases
Confidence Intervals
Denmark

Bibliografisk note

Copyright © 2010 Mosby, Inc. All rights reserved.

Citer dette

@article{aee5d6e59ac9407c997516d2def3686f,
title = "Diseases in children born to mothers with preeclampsia: a population-based sibling cohort study",
abstract = "OBJECTIVE:: We previously reported associations between preeclampsia and the occurrence of metabolic and respiratory diseases in the offspring. In this article we examine whether the associations were due to preeclampsia or factors leading to preeclampsia. STUDY DESIGN:: From 1978 through 2004, we identified 22,264 discordant sib-pairs in Denmark according to prenatal exposure to preeclampsia. Exposed children were compared to their unexposed siblings by using stratified Cox regression to estimate hazard ratios and 95{\%} confidence intervals for metabolic and respiratory diseases. RESULTS:: Exposed children had rather similar risks for metabolic disorders compared to their unexposed siblings. However, when the second child within each sib-pair was exposed, this child had an increased risk for respiratory diseases (hazard ratio, 1.55; 95{\%} confidence interval, 1.20-2.01). CONCLUSION:: Factors leading to preeclampsia may shape susceptibility to metabolic or respiratory diseases in the offspring but a programming effect on respiratory diseases induced by preeclampsia cannot be ruled out.",
author = "Chunsen Wu and N{\o}hr, {Ellen Aagaard} and Bech, {Bodil H} and Mogens Vestergaard and Catov, {Janet M} and J{\o}rn Olsen",
note = "Copyright {\circledC} 2010 Mosby, Inc. All rights reserved.",
year = "2011",
month = "2",
doi = "10.1016/j.ajog.2010.08.046",
language = "English",
volume = "204",
pages = "e1--e5",
journal = "American Journal of Obstetrics and Gynecology",
issn = "0002-9378",
publisher = "Mosby, Inc.",
number = "12",

}

Diseases in children born to mothers with preeclampsia: a population-based sibling cohort study. / Wu, Chunsen; Nøhr, Ellen Aagaard; Bech, Bodil H; Vestergaard, Mogens; Catov, Janet M; Olsen, Jørn.

I: American Journal of Obstetrics and Gynecology, Bind 204, Nr. 12, 02.2011, s. e1-e5.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Diseases in children born to mothers with preeclampsia: a population-based sibling cohort study

AU - Wu, Chunsen

AU - Nøhr, Ellen Aagaard

AU - Bech, Bodil H

AU - Vestergaard, Mogens

AU - Catov, Janet M

AU - Olsen, Jørn

N1 - Copyright © 2010 Mosby, Inc. All rights reserved.

PY - 2011/2

Y1 - 2011/2

N2 - OBJECTIVE:: We previously reported associations between preeclampsia and the occurrence of metabolic and respiratory diseases in the offspring. In this article we examine whether the associations were due to preeclampsia or factors leading to preeclampsia. STUDY DESIGN:: From 1978 through 2004, we identified 22,264 discordant sib-pairs in Denmark according to prenatal exposure to preeclampsia. Exposed children were compared to their unexposed siblings by using stratified Cox regression to estimate hazard ratios and 95% confidence intervals for metabolic and respiratory diseases. RESULTS:: Exposed children had rather similar risks for metabolic disorders compared to their unexposed siblings. However, when the second child within each sib-pair was exposed, this child had an increased risk for respiratory diseases (hazard ratio, 1.55; 95% confidence interval, 1.20-2.01). CONCLUSION:: Factors leading to preeclampsia may shape susceptibility to metabolic or respiratory diseases in the offspring but a programming effect on respiratory diseases induced by preeclampsia cannot be ruled out.

AB - OBJECTIVE:: We previously reported associations between preeclampsia and the occurrence of metabolic and respiratory diseases in the offspring. In this article we examine whether the associations were due to preeclampsia or factors leading to preeclampsia. STUDY DESIGN:: From 1978 through 2004, we identified 22,264 discordant sib-pairs in Denmark according to prenatal exposure to preeclampsia. Exposed children were compared to their unexposed siblings by using stratified Cox regression to estimate hazard ratios and 95% confidence intervals for metabolic and respiratory diseases. RESULTS:: Exposed children had rather similar risks for metabolic disorders compared to their unexposed siblings. However, when the second child within each sib-pair was exposed, this child had an increased risk for respiratory diseases (hazard ratio, 1.55; 95% confidence interval, 1.20-2.01). CONCLUSION:: Factors leading to preeclampsia may shape susceptibility to metabolic or respiratory diseases in the offspring but a programming effect on respiratory diseases induced by preeclampsia cannot be ruled out.

U2 - 10.1016/j.ajog.2010.08.046

DO - 10.1016/j.ajog.2010.08.046

M3 - Journal article

C2 - 20875632

VL - 204

SP - e1-e5

JO - American Journal of Obstetrics and Gynecology

JF - American Journal of Obstetrics and Gynecology

SN - 0002-9378

IS - 12

ER -