Direct glucocorticoid receptor-Stat5 interaction in hepatocytes controls body size and maturation-related gene expression

David Engblom, Jan-Wilhelm Kornfeld, Lukas Schwake, Francois Tronche, Andreas Reimann, Hartmut Beug, Lothar Hennighausen, Richard Moriggl, Günther Schütz

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Abstract

The glucocorticoid receptor regulates transcription through DNA binding as well as through cross-talk with other transcription factors. In hepatocytes, the glucocorticoid receptor is critical for normal postnatal growth. Using hepatocyte-specific and domain-selective mutations in the mouse we show that Stat5 in hepatocytes is essential for normal postnatal growth and that it mediates the growth-promoting effect of the glucocorticoid receptor through a direct interaction involving the N-terminal tetramerization domain of Stat5b. This interaction mediates a selective and unexpectedly extensive part of the transcriptional actions of these molecules since it controls the expression of gene sets involved in growth and sexual maturation.

OriginalsprogEngelsk
TidsskriftGenes & Development
Vol/bind21
Udgave nummer10
Sider (fra-til)1157-1162
ISSN0890-9369
DOI
StatusUdgivet - 15. maj 2007
Udgivet eksterntJa

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