DIGGER: exploring the functional role of alternative splicing in protein interactions

Zakaria Louadi, Kevin Yuan, Alexander Gress, Olga Tsoy, Olga V. Kalinina, Jan Baumbach, Tim Kacprowski*, Markus List*

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Abstrakt

Alternative splicing plays a major role in regulating the functional repertoire of the proteome. However, isoform-specific effects to protein-protein interactions (PPIs) are usually overlooked, making it impossible to judge the functional role of individual exons on a systems biology level. We overcome this barrier by integrating protein-protein interactions, domain-domain interactions and residue-level interactions information to lift exon expression analysis to a network level. Our user-friendly database DIGGER is available at https://exbio.wzw.tum.de/digger and allows users to seamlessly switch between isoform and exon-centric views of the interactome and to extract sub-networks of relevant isoforms, making it an essential resource for studying mechanistic consequences of alternative splicing.

OriginalsprogEngelsk
TidsskriftNucleic acids research
Vol/bind49
Udgave nummerD1
Sider (fra-til)D309-D318
ISSN0305-1048
DOI
StatusUdgivet - 8. jan. 2021

Bibliografisk note

Publisher Copyright:
© The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research.

Copyright:
This record is sourced from MEDLINE/PubMed, a database of the U.S. National Library of Medicine

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