Difusión simultánea de inositol y manitol en cerebro de rata

C Font, M Garía-Campos, A J Hansen, E Siemkowicz, A Gjedde

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The diffusion of both inositol and mannitol has been determined simultaneously by the integral bolus method in rat brain. The permeability constant (Kin) of inositol averaged 0.27 +/- 0.02 ml X (100 g)-1 X min-1 or 4 X 10(-7) cm X s-1 at a cerebral capillary surface area of 100 cm2 x g-1. The permeability of mannitol was 0.08 +/- 0.01 ml X (100 g)-1. min-1 or 1 X 10(-7) cm X s-1. Neither glucose nor galactose affected the inositol permeability. Hypoglycemia increased somewhat the Km value for mannitol. The basal ganglia showed an increase Km for both substrates as compared with those obtained for cortex, temporal and parietal tissues.

Bidragets oversatte titelSimultaneous diffusion of inositol and mannitol in the rat brain
TidsskriftRevista espanola de fisiologia
Udgave nummer3
Sider (fra-til)317-9
Antal sider3
StatusUdgivet - sep. 1982


  • Animals
  • Basal Ganglia/metabolism
  • Biological Transport, Active
  • Blood-Brain Barrier
  • Brain/metabolism
  • Cerebral Cortex/metabolism
  • Diffusion
  • Inositol/metabolism
  • Mannitol/metabolism
  • Parietal Lobe/metabolism
  • Rats
  • Rats, Inbred Strains
  • Temporal Lobe/metabolism

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  • Citationsformater

    Font, C., Garía-Campos, M., Hansen, A. J., Siemkowicz, E., & Gjedde, A. (1982). Difusión simultánea de inositol y manitol en cerebro de rata. Revista espanola de fisiologia, 38(3), 317-9.