Differential associations between brain 5-HT1A receptor binding and response to pain versus touch

Ilkka K Martikainen, Jussi Hirvonen, Ullamari Pesonen, Nora Hagelberg, Heikki Laurikainen, Heikki Tuikkala, Jaana Kajander, Kjell Någren, Jarmo Hietala, Antti Pertovaara

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Udgivelsesdato: 2009-Jul
OriginalsprogEngelsk
TidsskriftJournal of Neural Transmission
Vol/bind116
Udgave nummer7
Sider (fra-til)821-30
Antal sider9
ISSN0300-9564
DOI
StatusUdgivet - 1. jul. 2009
Udgivet eksterntJa

Fingeraftryk

Short-Term Memory
Ligands
Dorsal Raphe Nucleus
Psychological Signal Detection
N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide

Citer dette

Martikainen, I. K., Hirvonen, J., Pesonen, U., Hagelberg, N., Laurikainen, H., Tuikkala, H., ... Pertovaara, A. (2009). Differential associations between brain 5-HT1A receptor binding and response to pain versus touch. Journal of Neural Transmission, 116(7), 821-30. https://doi.org/10.1007/s00702-009-0248-3
Martikainen, Ilkka K ; Hirvonen, Jussi ; Pesonen, Ullamari ; Hagelberg, Nora ; Laurikainen, Heikki ; Tuikkala, Heikki ; Kajander, Jaana ; Någren, Kjell ; Hietala, Jarmo ; Pertovaara, Antti. / Differential associations between brain 5-HT1A receptor binding and response to pain versus touch. I: Journal of Neural Transmission. 2009 ; Bind 116, Nr. 7. s. 821-30.
@article{97c279100f2711dfaefb000ea68e967b,
title = "Differential associations between brain 5-HT1A receptor binding and response to pain versus touch",
abstract = "We studied whether brain serotonin 5-HT(1A) receptor availability is associated with response to noxious heat versus tactile stimuli, and short-term memory for heat pain. Psychophysical performance was assessed in 16 healthy subjects who had participated in a positron emission tomography study using [carbonyl-11C]WAY-100635 ligand for the assessment of 5-HT(1A) receptor binding potential (BP (ND)). Signal detection theory was applied to allow separate analysis of the subject's sensory-discriminative capacity (sensory factor) and the attitude toward reporting a sensation (response criterion; non-sensory factor). Subject's response criterion for heat pain was inversely correlated with 5-HT(1A) BP (ND) in the dorsal raphe, middle temporal gyrus, orbitofrontal cortex and posterior cingulum, whereas the subject's discriminative capacity for touch was inversely correlated with 5-HT(1A) BP (ND) in the cingulum, inferior temporal gyrus, and medial prefrontal cortex. Certainty ratings of the responses, but not hit rates, in the pain memory task were correlated with 5-HT(1A) BP (ND) in the dorsal raphe.",
author = "Martikainen, {Ilkka K} and Jussi Hirvonen and Ullamari Pesonen and Nora Hagelberg and Heikki Laurikainen and Heikki Tuikkala and Jaana Kajander and Kjell N{\aa}gren and Jarmo Hietala and Antti Pertovaara",
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Martikainen, IK, Hirvonen, J, Pesonen, U, Hagelberg, N, Laurikainen, H, Tuikkala, H, Kajander, J, Någren, K, Hietala, J & Pertovaara, A 2009, 'Differential associations between brain 5-HT1A receptor binding and response to pain versus touch', Journal of Neural Transmission, bind 116, nr. 7, s. 821-30. https://doi.org/10.1007/s00702-009-0248-3

Differential associations between brain 5-HT1A receptor binding and response to pain versus touch. / Martikainen, Ilkka K; Hirvonen, Jussi; Pesonen, Ullamari; Hagelberg, Nora; Laurikainen, Heikki; Tuikkala, Heikki; Kajander, Jaana; Någren, Kjell; Hietala, Jarmo; Pertovaara, Antti.

I: Journal of Neural Transmission, Bind 116, Nr. 7, 01.07.2009, s. 821-30.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Differential associations between brain 5-HT1A receptor binding and response to pain versus touch

AU - Martikainen, Ilkka K

AU - Hirvonen, Jussi

AU - Pesonen, Ullamari

AU - Hagelberg, Nora

AU - Laurikainen, Heikki

AU - Tuikkala, Heikki

AU - Kajander, Jaana

AU - Någren, Kjell

AU - Hietala, Jarmo

AU - Pertovaara, Antti

PY - 2009/7/1

Y1 - 2009/7/1

N2 - We studied whether brain serotonin 5-HT(1A) receptor availability is associated with response to noxious heat versus tactile stimuli, and short-term memory for heat pain. Psychophysical performance was assessed in 16 healthy subjects who had participated in a positron emission tomography study using [carbonyl-11C]WAY-100635 ligand for the assessment of 5-HT(1A) receptor binding potential (BP (ND)). Signal detection theory was applied to allow separate analysis of the subject's sensory-discriminative capacity (sensory factor) and the attitude toward reporting a sensation (response criterion; non-sensory factor). Subject's response criterion for heat pain was inversely correlated with 5-HT(1A) BP (ND) in the dorsal raphe, middle temporal gyrus, orbitofrontal cortex and posterior cingulum, whereas the subject's discriminative capacity for touch was inversely correlated with 5-HT(1A) BP (ND) in the cingulum, inferior temporal gyrus, and medial prefrontal cortex. Certainty ratings of the responses, but not hit rates, in the pain memory task were correlated with 5-HT(1A) BP (ND) in the dorsal raphe.

AB - We studied whether brain serotonin 5-HT(1A) receptor availability is associated with response to noxious heat versus tactile stimuli, and short-term memory for heat pain. Psychophysical performance was assessed in 16 healthy subjects who had participated in a positron emission tomography study using [carbonyl-11C]WAY-100635 ligand for the assessment of 5-HT(1A) receptor binding potential (BP (ND)). Signal detection theory was applied to allow separate analysis of the subject's sensory-discriminative capacity (sensory factor) and the attitude toward reporting a sensation (response criterion; non-sensory factor). Subject's response criterion for heat pain was inversely correlated with 5-HT(1A) BP (ND) in the dorsal raphe, middle temporal gyrus, orbitofrontal cortex and posterior cingulum, whereas the subject's discriminative capacity for touch was inversely correlated with 5-HT(1A) BP (ND) in the cingulum, inferior temporal gyrus, and medial prefrontal cortex. Certainty ratings of the responses, but not hit rates, in the pain memory task were correlated with 5-HT(1A) BP (ND) in the dorsal raphe.

U2 - 10.1007/s00702-009-0248-3

DO - 10.1007/s00702-009-0248-3

M3 - Journal article

C2 - 19533293

VL - 116

SP - 821

EP - 830

JO - Journal of Neural Transmission

JF - Journal of Neural Transmission

SN - 0300-9564

IS - 7

ER -

Martikainen IK, Hirvonen J, Pesonen U, Hagelberg N, Laurikainen H, Tuikkala H et al. Differential associations between brain 5-HT1A receptor binding and response to pain versus touch. Journal of Neural Transmission. 2009 jul 1;116(7):821-30. https://doi.org/10.1007/s00702-009-0248-3