Different effects of calcium antagonist and beta-blocker therapy on left-ventricular diastolic function in ischemic heart disease. A direct comparison of the impact of mibefradil and atenolol

C Hassager, K Thygesen, P Grande, J Fischer Hansen, H Mickley, I Gustafsson, K Skagen, F Steensgaard-Hansen

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Udgivelsesdato: 2001-null
OriginalsprogEngelsk
TidsskriftCardiology
Vol/bind96
Udgave nummer2
Sider (fra-til)65-71
Antal sider6
ISSN0008-6312
StatusUdgivet - 1. jan. 2001

Fingeraftryk

Mibefradil
Left Ventricular Function
Stable Angina
Deceleration
Doppler Echocardiography

Bibliografisk note

Copyright 2001 S. Karger AG, Basel

Citer dette

Hassager, C ; Thygesen, K ; Grande, P ; Fischer Hansen, J ; Mickley, H ; Gustafsson, I ; Skagen, K ; Steensgaard-Hansen, F. / Different effects of calcium antagonist and beta-blocker therapy on left-ventricular diastolic function in ischemic heart disease. A direct comparison of the impact of mibefradil and atenolol. I: Cardiology. 2001 ; Bind 96, Nr. 2. s. 65-71.
@article{f84e225046fb11df937d000ea68e967b,
title = "Different effects of calcium antagonist and beta-blocker therapy on left-ventricular diastolic function in ischemic heart disease. A direct comparison of the impact of mibefradil and atenolol",
abstract = "OBJECTIVE: To compare the effect of a calcium antagonist and a beta-blocker on left-ventricular diastolic function in patients with ischemic heart disease. METHODS: 138 patients with chronic stable angina pectoris were randomized in a multicenter, double-blind trial to treatment with either mibefradil or atenolol for 6 weeks (50 mg once daily for 2 weeks followed by 100 mg once daily for 4 weeks). The ratio between early (E) and late (A) diastolic mitral flow velocities (E/A), the E wave deceleration time (DT) and the left ventricular isovolumetric relaxation time (IRT) were measured by Doppler echocardiography as parameters of left-ventricular diastolic function initially, after 4 and after 6 weeks of treatment. RESULTS: Mibefradil did not change the E/A ratio significantly (+4{\%}, NS), while atenolol treatment resulted in a significant increase in the E/A ratio (+20{\%}, p < 0.001). Mibefradil treatment, on the other hand, resulted in a significant decrease (-8{\%}, p < 0.001) in IRT, while atenolol treatment did not change IRT. Neither mibefradil nor atenolol treatment changed DT significantly. CONCLUSIONS: Both mibefradil and atenolol treatment significantly improves echocardiographic indices of left-ventricular diastolic function in patients with chronic stable angina. However, they affect different parameters and thus apparently act through different mechanisms.",
keywords = "Adrenergic beta-Antagonists, Aged, Angina Pectoris, Atenolol, Blood Flow Velocity, Blood Pressure, Calcium Channel Blockers, Diastole, Double-Blind Method, Echocardiography, Doppler, Female, Heart Rate, Heart Septum, Humans, Male, Mibefradil, Middle Aged, Mitral Valve, Time Factors, Ventricular Function, Left",
author = "C Hassager and K Thygesen and P Grande and {Fischer Hansen}, J and H Mickley and I Gustafsson and K Skagen and F Steensgaard-Hansen",
note = "Copyright 2001 S. Karger AG, Basel",
year = "2001",
month = "1",
day = "1",
language = "English",
volume = "96",
pages = "65--71",
journal = "Cardiology",
issn = "0008-6312",
publisher = "S. Karger AG",
number = "2",

}

Hassager, C, Thygesen, K, Grande, P, Fischer Hansen, J, Mickley, H, Gustafsson, I, Skagen, K & Steensgaard-Hansen, F 2001, 'Different effects of calcium antagonist and beta-blocker therapy on left-ventricular diastolic function in ischemic heart disease. A direct comparison of the impact of mibefradil and atenolol', Cardiology, bind 96, nr. 2, s. 65-71.

Different effects of calcium antagonist and beta-blocker therapy on left-ventricular diastolic function in ischemic heart disease. A direct comparison of the impact of mibefradil and atenolol. / Hassager, C; Thygesen, K; Grande, P; Fischer Hansen, J; Mickley, H; Gustafsson, I; Skagen, K; Steensgaard-Hansen, F.

I: Cardiology, Bind 96, Nr. 2, 01.01.2001, s. 65-71.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Different effects of calcium antagonist and beta-blocker therapy on left-ventricular diastolic function in ischemic heart disease. A direct comparison of the impact of mibefradil and atenolol

AU - Hassager, C

AU - Thygesen, K

AU - Grande, P

AU - Fischer Hansen, J

AU - Mickley, H

AU - Gustafsson, I

AU - Skagen, K

AU - Steensgaard-Hansen, F

N1 - Copyright 2001 S. Karger AG, Basel

PY - 2001/1/1

Y1 - 2001/1/1

N2 - OBJECTIVE: To compare the effect of a calcium antagonist and a beta-blocker on left-ventricular diastolic function in patients with ischemic heart disease. METHODS: 138 patients with chronic stable angina pectoris were randomized in a multicenter, double-blind trial to treatment with either mibefradil or atenolol for 6 weeks (50 mg once daily for 2 weeks followed by 100 mg once daily for 4 weeks). The ratio between early (E) and late (A) diastolic mitral flow velocities (E/A), the E wave deceleration time (DT) and the left ventricular isovolumetric relaxation time (IRT) were measured by Doppler echocardiography as parameters of left-ventricular diastolic function initially, after 4 and after 6 weeks of treatment. RESULTS: Mibefradil did not change the E/A ratio significantly (+4%, NS), while atenolol treatment resulted in a significant increase in the E/A ratio (+20%, p < 0.001). Mibefradil treatment, on the other hand, resulted in a significant decrease (-8%, p < 0.001) in IRT, while atenolol treatment did not change IRT. Neither mibefradil nor atenolol treatment changed DT significantly. CONCLUSIONS: Both mibefradil and atenolol treatment significantly improves echocardiographic indices of left-ventricular diastolic function in patients with chronic stable angina. However, they affect different parameters and thus apparently act through different mechanisms.

AB - OBJECTIVE: To compare the effect of a calcium antagonist and a beta-blocker on left-ventricular diastolic function in patients with ischemic heart disease. METHODS: 138 patients with chronic stable angina pectoris were randomized in a multicenter, double-blind trial to treatment with either mibefradil or atenolol for 6 weeks (50 mg once daily for 2 weeks followed by 100 mg once daily for 4 weeks). The ratio between early (E) and late (A) diastolic mitral flow velocities (E/A), the E wave deceleration time (DT) and the left ventricular isovolumetric relaxation time (IRT) were measured by Doppler echocardiography as parameters of left-ventricular diastolic function initially, after 4 and after 6 weeks of treatment. RESULTS: Mibefradil did not change the E/A ratio significantly (+4%, NS), while atenolol treatment resulted in a significant increase in the E/A ratio (+20%, p < 0.001). Mibefradil treatment, on the other hand, resulted in a significant decrease (-8%, p < 0.001) in IRT, while atenolol treatment did not change IRT. Neither mibefradil nor atenolol treatment changed DT significantly. CONCLUSIONS: Both mibefradil and atenolol treatment significantly improves echocardiographic indices of left-ventricular diastolic function in patients with chronic stable angina. However, they affect different parameters and thus apparently act through different mechanisms.

KW - Adrenergic beta-Antagonists

KW - Aged

KW - Angina Pectoris

KW - Atenolol

KW - Blood Flow Velocity

KW - Blood Pressure

KW - Calcium Channel Blockers

KW - Diastole

KW - Double-Blind Method

KW - Echocardiography, Doppler

KW - Female

KW - Heart Rate

KW - Heart Septum

KW - Humans

KW - Male

KW - Mibefradil

KW - Middle Aged

KW - Mitral Valve

KW - Time Factors

KW - Ventricular Function, Left

M3 - Journal article

C2 - 11740134

VL - 96

SP - 65

EP - 71

JO - Cardiology

JF - Cardiology

SN - 0008-6312

IS - 2

ER -