Different doses of amodiaquine and chloroquine for treatment of uncomplicated malaria in children in Guinea-Bissau: implications for future treatment recommendations

Poul-Erik Kofoed, Johan Ursing, Anja Poulsen, Amabelia Rodrigues, Yngve Bergquist, Peter Aaby, Lars Rombo

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Udgivelsesdato: 2007-Mar
OriginalsprogEngelsk
TidsskriftTransactions of the Royal Society of Tropical Medicine and Hygiene
Vol/bind101
Udgave nummer3
Sider (fra-til)231-238
Antal sider7
ISSN0035-9203
DOI
StatusUdgivet - 1. mar. 2007

Fingeraftryk

Guinea-Bissau
Chloroquine
Malaria
Polymerase Chain Reaction
Falciparum Malaria
Plasmodium falciparum
Random Allocation
Pharmaceutical Preparations

Citer dette

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title = "Different doses of amodiaquine and chloroquine for treatment of uncomplicated malaria in children in Guinea-Bissau: implications for future treatment recommendations",
abstract = "The aim of the present study was to compare different doses of chloroquine (CQ) and amodiaquine (AQ) for the treatment of falciparum malaria in children. Children with Plasmodium falciparum monoinfection were allocated by block randomisation to treatment with CQ 50/kg mg or 25 mg/kg or AQ 15 mg/kg or 30 mg/kg. The main outcomes were the cumulative adequate clinical and parasitological response (ACPR) rates and the number of true recrudescences as determined by PCR. A total of 729 children were included. In an evaluability analysis, the PCR-uncorrected cumulative ACPR rates on Day 28 for the treatment groups CQ 50/kg mg or 25 mg/kg and AQ 15 mg/kg or 30 mg/kg were 90{\%}, 76{\%}, 92{\%} and 94{\%}, respectively; the PCR-adjusted ACPR rates on Day 28 were 92{\%}, 80{\%}, 94{\%} and 94{\%}, respectively. No differences in adverse effects were observed. AQ has a high cure rate given as 30 mg/kg and 15 mg/kg, although it is not superior to treatment with CQ 50 mg/kg. However, 25 mg/kg of CQ is less efficient. As an interim option, Guinea-Bissau could change the recommended first-line treatment of uncomplicated malaria to CQ 50 mg/kg, reserving AQ as a partner drug for a future combination therapy.",
keywords = "Adolescent, Amodiaquine, Antimalarials, Child, Child, Preschool, Chloroquine, Dose-Response Relationship, Drug, Drug Administration Schedule, Female, Follow-Up Studies, Humans, Infant, Malaria, Falciparum, Male, Treatment Outcome",
author = "Poul-Erik Kofoed and Johan Ursing and Anja Poulsen and Amabelia Rodrigues and Yngve Bergquist and Peter Aaby and Lars Rombo",
year = "2007",
month = "3",
day = "1",
doi = "10.1016/j.trstmh.2006.05.008",
language = "English",
volume = "101",
pages = "231--238",
journal = "Transactions of the Royal Society of Tropical Medicine and Hygiene",
issn = "0035-9203",
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Different doses of amodiaquine and chloroquine for treatment of uncomplicated malaria in children in Guinea-Bissau : implications for future treatment recommendations. / Kofoed, Poul-Erik; Ursing, Johan; Poulsen, Anja; Rodrigues, Amabelia; Bergquist, Yngve; Aaby, Peter; Rombo, Lars.

I: Transactions of the Royal Society of Tropical Medicine and Hygiene, Bind 101, Nr. 3, 01.03.2007, s. 231-238.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Different doses of amodiaquine and chloroquine for treatment of uncomplicated malaria in children in Guinea-Bissau

T2 - implications for future treatment recommendations

AU - Kofoed, Poul-Erik

AU - Ursing, Johan

AU - Poulsen, Anja

AU - Rodrigues, Amabelia

AU - Bergquist, Yngve

AU - Aaby, Peter

AU - Rombo, Lars

PY - 2007/3/1

Y1 - 2007/3/1

N2 - The aim of the present study was to compare different doses of chloroquine (CQ) and amodiaquine (AQ) for the treatment of falciparum malaria in children. Children with Plasmodium falciparum monoinfection were allocated by block randomisation to treatment with CQ 50/kg mg or 25 mg/kg or AQ 15 mg/kg or 30 mg/kg. The main outcomes were the cumulative adequate clinical and parasitological response (ACPR) rates and the number of true recrudescences as determined by PCR. A total of 729 children were included. In an evaluability analysis, the PCR-uncorrected cumulative ACPR rates on Day 28 for the treatment groups CQ 50/kg mg or 25 mg/kg and AQ 15 mg/kg or 30 mg/kg were 90%, 76%, 92% and 94%, respectively; the PCR-adjusted ACPR rates on Day 28 were 92%, 80%, 94% and 94%, respectively. No differences in adverse effects were observed. AQ has a high cure rate given as 30 mg/kg and 15 mg/kg, although it is not superior to treatment with CQ 50 mg/kg. However, 25 mg/kg of CQ is less efficient. As an interim option, Guinea-Bissau could change the recommended first-line treatment of uncomplicated malaria to CQ 50 mg/kg, reserving AQ as a partner drug for a future combination therapy.

AB - The aim of the present study was to compare different doses of chloroquine (CQ) and amodiaquine (AQ) for the treatment of falciparum malaria in children. Children with Plasmodium falciparum monoinfection were allocated by block randomisation to treatment with CQ 50/kg mg or 25 mg/kg or AQ 15 mg/kg or 30 mg/kg. The main outcomes were the cumulative adequate clinical and parasitological response (ACPR) rates and the number of true recrudescences as determined by PCR. A total of 729 children were included. In an evaluability analysis, the PCR-uncorrected cumulative ACPR rates on Day 28 for the treatment groups CQ 50/kg mg or 25 mg/kg and AQ 15 mg/kg or 30 mg/kg were 90%, 76%, 92% and 94%, respectively; the PCR-adjusted ACPR rates on Day 28 were 92%, 80%, 94% and 94%, respectively. No differences in adverse effects were observed. AQ has a high cure rate given as 30 mg/kg and 15 mg/kg, although it is not superior to treatment with CQ 50 mg/kg. However, 25 mg/kg of CQ is less efficient. As an interim option, Guinea-Bissau could change the recommended first-line treatment of uncomplicated malaria to CQ 50 mg/kg, reserving AQ as a partner drug for a future combination therapy.

KW - Adolescent

KW - Amodiaquine

KW - Antimalarials

KW - Child

KW - Child, Preschool

KW - Chloroquine

KW - Dose-Response Relationship, Drug

KW - Drug Administration Schedule

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Infant

KW - Malaria, Falciparum

KW - Male

KW - Treatment Outcome

U2 - 10.1016/j.trstmh.2006.05.008

DO - 10.1016/j.trstmh.2006.05.008

M3 - Journal article

C2 - 16904718

VL - 101

SP - 231

EP - 238

JO - Transactions of the Royal Society of Tropical Medicine and Hygiene

JF - Transactions of the Royal Society of Tropical Medicine and Hygiene

SN - 0035-9203

IS - 3

ER -