Differences in treatment and survival in young and elderly patients with colorectal cancer

Erik Frostberg*, Jan Lindebjerg, Flemming Brandt Sørensen, Hans B. Rahr

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Abstrakt

INTRODUCTION. The incidence of colorectal cancer (CRC) in patients ≤ 40 years of age seems to follow an increasing trend worldwide. Previous studies have reported conflicting data on treatment intensity and survival in young patients with CRC. The aim of this study was to describe treatment and survival data in a national cohort of young Danish CRC patients in the 2001-2013 period and to compare these data with data on a national cohort of elderly patients with CRC. METHODS. In a retrospective study design, we analysed data on pre-operative management, treatment and overall survival in a national cohort of 484 young (18-40 years) and 14,647 elderly (66-75 years) CRC patients. Cox regression models were used to calculate adjusted hazard functions of overall survival. RESULTS. Surgical treatment did not differ markedly between age groups, but young patients received more oncological treatment and had a better stage-specific five-year overall survival than elderly patients. In an adjusted model, the hazard ratio for young patients with stage I-III disease was 0.67 (95% confidence interval (CI): 0.48-0.95) for colon cancer; 0.61 (95% CI: 0.37-0.99) for rectal cancer. CONCLUSION. Despite more advanced clinical stages of disease, young CRC patients had a better survival than elderly CRC patients in this national cohort.

OriginalsprogEngelsk
ArtikelnummerA12210941
TidsskriftDanish Medical Journal
Vol/bind69
Udgave nummer6
Antal sider9
ISSN2245-1919
StatusUdgivet - 16. maj 2022

Bibliografisk note

Funding Information:
FUNDING. The study was funded by Krista og Viggo Petersens Fond; Civilingeniør Bengt Bøgh og Hustru Inge Bøghs Fond; and Arvekapitalen efter Ane Mette Nielsen til lægevidenskabelig forskning ved Vejle Sygehus.

Publisher Copyright:
© 2022, Almindelige Danske Laegeforening. All rights reserved.

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