Dietary Polyphenols in the Aetiology of Crohn's Disease and Ulcerative Colitis-A Multicenter European Prospective Cohort Study (EPIC)

Yunxia Lu, Raul Zamora-Ros, Simon Chan, Amanda J Cross, Heather Ward, Paula Jakszyn, Robert Luben, Jorrit L Opstelten, Bas Oldenburg, Göran Hallmans, Pontus Karling, Olof Grip, Timothy Key, Manuela M Bergmann, Heiner Boeing, Kim Overvad, Domenico Palli, Giovanna Masala, Kay-Tee Khaw, Antoine Racine & 11 andre Franck Carbonnel, Marie-Christine Boutron-Ruault, Vibeke Andersen, Anja Olsen, Anne Tjonneland, Rudolf Kaaks, Rosario Tumino, Antonia Trichopoulou, Augustin Scalbert, Elio Riboli, Andrew R Hart

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Resumé

BACKGROUND: Oxidative stress may be involved in the aetiology of inflammatory bowel disease and whether dietary polyphenols, which possess antioxidants properties, prevent its development is unknown.

METHODS: A total of 401,326 men and women aged 20 to 80 years from 8 countries were recruited between 1991 and 1998 and at baseline completed validated food frequency questionnaires. Dietary polyphenol intake was measured using Phenol-Explorer, a database with information on the content of 502 polyphenols. Incident cases of Crohn's diseases (CD) and ulcerative colitis (UC) were identified during the follow-up period of up to December 2010. A nested case-control study using conditional logistic regression estimated the odds ratios (ORs), and 95% confidence intervals, for polyphenol intake (categories based on quartiles) and developing CD or UC.

RESULTS: In total, 110 CD (73% women) and 244 UC (57% women) cases were identified and matched to 440 and 976 controls, respectively. Total polyphenol intake was not associated with CD (P trend = 0.17) or UC (P trend = 0.16). For flavones and CD, there were reduced odds for all quartiles, which were statistically significant for the third (OR3rd versus 1st quartile = 0.33; 95% confidence interval, 0.15-0.69) and there was an inverse trend across quartiles (P = 0.03). Similarly, for resveratrol, there was an inverse association with CD (OR4th versus 1st quartile = 0.40; 95% confidence interval, 0.20-0.82) with an inverse trend across quartiles (P = 0.02). No significant associations between subtypes of polyphenols and UC were found. Effect modification by smoking in CD was documented with borderline statistical significance.

CONCLUSIONS: The data supports a potential role of flavones and resveratrol in the risk of developing CD; future aetiological studies should investigate these dietary components and further examine the potential for residual confounding.

OriginalsprogEngelsk
TidsskriftInflammatory Bowel Diseases
Vol/bind23
Udgave nummer12
Sider (fra-til)2072-2082
ISSN1078-0998
DOI
StatusUdgivet - 2017

Fingeraftryk

Ulcerative Colitis
Crohn Disease
Cohort Studies
Prospective Studies
Confidence Intervals
Phenol
Inflammatory Bowel Diseases
Case-Control Studies
Logistic Models
Smoking
Odds Ratio
Databases
Food

Citer dette

Lu, Yunxia ; Zamora-Ros, Raul ; Chan, Simon ; Cross, Amanda J ; Ward, Heather ; Jakszyn, Paula ; Luben, Robert ; Opstelten, Jorrit L ; Oldenburg, Bas ; Hallmans, Göran ; Karling, Pontus ; Grip, Olof ; Key, Timothy ; Bergmann, Manuela M ; Boeing, Heiner ; Overvad, Kim ; Palli, Domenico ; Masala, Giovanna ; Khaw, Kay-Tee ; Racine, Antoine ; Carbonnel, Franck ; Boutron-Ruault, Marie-Christine ; Andersen, Vibeke ; Olsen, Anja ; Tjonneland, Anne ; Kaaks, Rudolf ; Tumino, Rosario ; Trichopoulou, Antonia ; Scalbert, Augustin ; Riboli, Elio ; Hart, Andrew R. / Dietary Polyphenols in the Aetiology of Crohn's Disease and Ulcerative Colitis-A Multicenter European Prospective Cohort Study (EPIC). I: Inflammatory Bowel Diseases. 2017 ; Bind 23, Nr. 12. s. 2072-2082.
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title = "Dietary Polyphenols in the Aetiology of Crohn's Disease and Ulcerative Colitis-A Multicenter European Prospective Cohort Study (EPIC)",
abstract = "BACKGROUND: Oxidative stress may be involved in the aetiology of inflammatory bowel disease and whether dietary polyphenols, which possess antioxidants properties, prevent its development is unknown.METHODS: A total of 401,326 men and women aged 20 to 80 years from 8 countries were recruited between 1991 and 1998 and at baseline completed validated food frequency questionnaires. Dietary polyphenol intake was measured using Phenol-Explorer, a database with information on the content of 502 polyphenols. Incident cases of Crohn's diseases (CD) and ulcerative colitis (UC) were identified during the follow-up period of up to December 2010. A nested case-control study using conditional logistic regression estimated the odds ratios (ORs), and 95{\%} confidence intervals, for polyphenol intake (categories based on quartiles) and developing CD or UC.RESULTS: In total, 110 CD (73{\%} women) and 244 UC (57{\%} women) cases were identified and matched to 440 and 976 controls, respectively. Total polyphenol intake was not associated with CD (P trend = 0.17) or UC (P trend = 0.16). For flavones and CD, there were reduced odds for all quartiles, which were statistically significant for the third (OR3rd versus 1st quartile = 0.33; 95{\%} confidence interval, 0.15-0.69) and there was an inverse trend across quartiles (P = 0.03). Similarly, for resveratrol, there was an inverse association with CD (OR4th versus 1st quartile = 0.40; 95{\%} confidence interval, 0.20-0.82) with an inverse trend across quartiles (P = 0.02). No significant associations between subtypes of polyphenols and UC were found. Effect modification by smoking in CD was documented with borderline statistical significance.CONCLUSIONS: The data supports a potential role of flavones and resveratrol in the risk of developing CD; future aetiological studies should investigate these dietary components and further examine the potential for residual confounding.",
keywords = "Journal Article",
author = "Yunxia Lu and Raul Zamora-Ros and Simon Chan and Cross, {Amanda J} and Heather Ward and Paula Jakszyn and Robert Luben and Opstelten, {Jorrit L} and Bas Oldenburg and G{\"o}ran Hallmans and Pontus Karling and Olof Grip and Timothy Key and Bergmann, {Manuela M} and Heiner Boeing and Kim Overvad and Domenico Palli and Giovanna Masala and Kay-Tee Khaw and Antoine Racine and Franck Carbonnel and Marie-Christine Boutron-Ruault and Vibeke Andersen and Anja Olsen and Anne Tjonneland and Rudolf Kaaks and Rosario Tumino and Antonia Trichopoulou and Augustin Scalbert and Elio Riboli and Hart, {Andrew R}",
year = "2017",
doi = "10.1097/MIB.0000000000001108",
language = "English",
volume = "23",
pages = "2072--2082",
journal = "Inflammatory Bowel Diseases",
issn = "1078-0998",
publisher = "Lippincott Williams & Wilkins",
number = "12",

}

Lu, Y, Zamora-Ros, R, Chan, S, Cross, AJ, Ward, H, Jakszyn, P, Luben, R, Opstelten, JL, Oldenburg, B, Hallmans, G, Karling, P, Grip, O, Key, T, Bergmann, MM, Boeing, H, Overvad, K, Palli, D, Masala, G, Khaw, K-T, Racine, A, Carbonnel, F, Boutron-Ruault, M-C, Andersen, V, Olsen, A, Tjonneland, A, Kaaks, R, Tumino, R, Trichopoulou, A, Scalbert, A, Riboli, E & Hart, AR 2017, 'Dietary Polyphenols in the Aetiology of Crohn's Disease and Ulcerative Colitis-A Multicenter European Prospective Cohort Study (EPIC)', Inflammatory Bowel Diseases, bind 23, nr. 12, s. 2072-2082. https://doi.org/10.1097/MIB.0000000000001108

Dietary Polyphenols in the Aetiology of Crohn's Disease and Ulcerative Colitis-A Multicenter European Prospective Cohort Study (EPIC). / Lu, Yunxia; Zamora-Ros, Raul; Chan, Simon; Cross, Amanda J; Ward, Heather; Jakszyn, Paula; Luben, Robert; Opstelten, Jorrit L; Oldenburg, Bas; Hallmans, Göran; Karling, Pontus; Grip, Olof; Key, Timothy; Bergmann, Manuela M; Boeing, Heiner; Overvad, Kim; Palli, Domenico; Masala, Giovanna; Khaw, Kay-Tee; Racine, Antoine; Carbonnel, Franck; Boutron-Ruault, Marie-Christine; Andersen, Vibeke; Olsen, Anja; Tjonneland, Anne; Kaaks, Rudolf; Tumino, Rosario; Trichopoulou, Antonia; Scalbert, Augustin; Riboli, Elio; Hart, Andrew R.

I: Inflammatory Bowel Diseases, Bind 23, Nr. 12, 2017, s. 2072-2082.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Dietary Polyphenols in the Aetiology of Crohn's Disease and Ulcerative Colitis-A Multicenter European Prospective Cohort Study (EPIC)

AU - Lu, Yunxia

AU - Zamora-Ros, Raul

AU - Chan, Simon

AU - Cross, Amanda J

AU - Ward, Heather

AU - Jakszyn, Paula

AU - Luben, Robert

AU - Opstelten, Jorrit L

AU - Oldenburg, Bas

AU - Hallmans, Göran

AU - Karling, Pontus

AU - Grip, Olof

AU - Key, Timothy

AU - Bergmann, Manuela M

AU - Boeing, Heiner

AU - Overvad, Kim

AU - Palli, Domenico

AU - Masala, Giovanna

AU - Khaw, Kay-Tee

AU - Racine, Antoine

AU - Carbonnel, Franck

AU - Boutron-Ruault, Marie-Christine

AU - Andersen, Vibeke

AU - Olsen, Anja

AU - Tjonneland, Anne

AU - Kaaks, Rudolf

AU - Tumino, Rosario

AU - Trichopoulou, Antonia

AU - Scalbert, Augustin

AU - Riboli, Elio

AU - Hart, Andrew R

PY - 2017

Y1 - 2017

N2 - BACKGROUND: Oxidative stress may be involved in the aetiology of inflammatory bowel disease and whether dietary polyphenols, which possess antioxidants properties, prevent its development is unknown.METHODS: A total of 401,326 men and women aged 20 to 80 years from 8 countries were recruited between 1991 and 1998 and at baseline completed validated food frequency questionnaires. Dietary polyphenol intake was measured using Phenol-Explorer, a database with information on the content of 502 polyphenols. Incident cases of Crohn's diseases (CD) and ulcerative colitis (UC) were identified during the follow-up period of up to December 2010. A nested case-control study using conditional logistic regression estimated the odds ratios (ORs), and 95% confidence intervals, for polyphenol intake (categories based on quartiles) and developing CD or UC.RESULTS: In total, 110 CD (73% women) and 244 UC (57% women) cases were identified and matched to 440 and 976 controls, respectively. Total polyphenol intake was not associated with CD (P trend = 0.17) or UC (P trend = 0.16). For flavones and CD, there were reduced odds for all quartiles, which were statistically significant for the third (OR3rd versus 1st quartile = 0.33; 95% confidence interval, 0.15-0.69) and there was an inverse trend across quartiles (P = 0.03). Similarly, for resveratrol, there was an inverse association with CD (OR4th versus 1st quartile = 0.40; 95% confidence interval, 0.20-0.82) with an inverse trend across quartiles (P = 0.02). No significant associations between subtypes of polyphenols and UC were found. Effect modification by smoking in CD was documented with borderline statistical significance.CONCLUSIONS: The data supports a potential role of flavones and resveratrol in the risk of developing CD; future aetiological studies should investigate these dietary components and further examine the potential for residual confounding.

AB - BACKGROUND: Oxidative stress may be involved in the aetiology of inflammatory bowel disease and whether dietary polyphenols, which possess antioxidants properties, prevent its development is unknown.METHODS: A total of 401,326 men and women aged 20 to 80 years from 8 countries were recruited between 1991 and 1998 and at baseline completed validated food frequency questionnaires. Dietary polyphenol intake was measured using Phenol-Explorer, a database with information on the content of 502 polyphenols. Incident cases of Crohn's diseases (CD) and ulcerative colitis (UC) were identified during the follow-up period of up to December 2010. A nested case-control study using conditional logistic regression estimated the odds ratios (ORs), and 95% confidence intervals, for polyphenol intake (categories based on quartiles) and developing CD or UC.RESULTS: In total, 110 CD (73% women) and 244 UC (57% women) cases were identified and matched to 440 and 976 controls, respectively. Total polyphenol intake was not associated with CD (P trend = 0.17) or UC (P trend = 0.16). For flavones and CD, there were reduced odds for all quartiles, which were statistically significant for the third (OR3rd versus 1st quartile = 0.33; 95% confidence interval, 0.15-0.69) and there was an inverse trend across quartiles (P = 0.03). Similarly, for resveratrol, there was an inverse association with CD (OR4th versus 1st quartile = 0.40; 95% confidence interval, 0.20-0.82) with an inverse trend across quartiles (P = 0.02). No significant associations between subtypes of polyphenols and UC were found. Effect modification by smoking in CD was documented with borderline statistical significance.CONCLUSIONS: The data supports a potential role of flavones and resveratrol in the risk of developing CD; future aetiological studies should investigate these dietary components and further examine the potential for residual confounding.

KW - Journal Article

U2 - 10.1097/MIB.0000000000001108

DO - 10.1097/MIB.0000000000001108

M3 - Journal article

VL - 23

SP - 2072

EP - 2082

JO - Inflammatory Bowel Diseases

JF - Inflammatory Bowel Diseases

SN - 1078-0998

IS - 12

ER -