TY - JOUR
T1 - Diagnostic value of kappa free light chain index in patients with primary progressive multiple sclerosis - a multicentre study
AU - Hegen, Harald
AU - Berek, Klaus
AU - Cavalla, Paola
AU - Christiansen, Mikael
AU - Emeršič, Andreja
AU - Di Filippo, Massimiliano
AU - Gaetani, Lorenzo
AU - Hassler, Michaela
AU - Leurs, Cyra
AU - Milosavljevic, Dejan
AU - van Pesch, Vincent
AU - Petersen, Thor
AU - Presslauer, Stefan
AU - Rosenstein, Igal
AU - Rot, Uroš
AU - Schnabl, Christine
AU - Teunissen, Charlotte
AU - Vecchio, Domizia
AU - Vercellino, Marco
AU - Deisenhammer, Florian
PY - 2023
Y1 - 2023
N2 - BACKGROUND: Kappa free light chains (κ-FLC) in the cerebrospinal fluid (CSF) are an emerging biomarker in multiple sclerosis (MS).OBJECTIVE: To investigate whether κ-FLC index has similar diagnostic value in patients with primary progressive multiple sclerosis (PPMS) compared to oligoclonal bands (OCB).METHODS: Patients with PPMS were recruited through 11 MS centres across 7 countries. κ-FLC were measured by immunonephelometry/-turbidimetry. OCB were determined by isoelectric focusing and immunofixation.RESULTS: A total of 174 patients (mean age of 52±11 years, 51% males) were included. κ-FLC index using a cut-off of 6.1 was positive in 161 (93%) and OCB in 153 (88%) patients.CONCLUSION: κ-FLC index shows similar diagnostic sensitivity than OCB in PPMS.
AB - BACKGROUND: Kappa free light chains (κ-FLC) in the cerebrospinal fluid (CSF) are an emerging biomarker in multiple sclerosis (MS).OBJECTIVE: To investigate whether κ-FLC index has similar diagnostic value in patients with primary progressive multiple sclerosis (PPMS) compared to oligoclonal bands (OCB).METHODS: Patients with PPMS were recruited through 11 MS centres across 7 countries. κ-FLC were measured by immunonephelometry/-turbidimetry. OCB were determined by isoelectric focusing and immunofixation.RESULTS: A total of 174 patients (mean age of 52±11 years, 51% males) were included. κ-FLC index using a cut-off of 6.1 was positive in 161 (93%) and OCB in 153 (88%) patients.CONCLUSION: κ-FLC index shows similar diagnostic sensitivity than OCB in PPMS.
KW - Male
KW - Humans
KW - Adult
KW - Middle Aged
KW - Female
KW - Multiple Sclerosis/diagnosis
KW - Multiple Sclerosis, Chronic Progressive/diagnosis
KW - Immunoglobulin Light Chains
KW - Immunoglobulin kappa-Chains/cerebrospinal fluid
KW - Biomarkers/cerebrospinal fluid
KW - Oligoclonal Bands/cerebrospinal fluid
U2 - 10.3389/fimmu.2023.1327947
DO - 10.3389/fimmu.2023.1327947
M3 - Journal article
C2 - 38169789
SN - 1664-3224
VL - 14
SP - 1327947
JO - Frontiers in Immunology
JF - Frontiers in Immunology
ER -