Diabetes mellitus prevalence in tuberculosis patients and the background population in Guinea-Bissau: a disease burden study from the capital Bissau

Thorny L Haraldsdottir, Frauke Rudolf, Morten Bjerregaard-Andersen, Luis Carlos Joaquím, Kirstine Stochholm, Victor F Gomes, Henning Beck-Nielsen, Lars Ostergaard, Peter Aaby, Christian Wejse

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Resumé

BACKGROUND: Data regarding the association between diabetes mellitus (DM) and tuberculosis (TB) in Africa are scare. We did a DM screening survey among TB patients and non-TB controls in Guinea-Bissau.

METHODS: The study was conducted at the Bandim Health Project (BHP) in the capital Bissau. From July 2010 to July 2011, newly diagnosed TB cases were identified through a TB notification system. Concurrently, non-TB controls were selected randomly from the BHP's demographic surveillance database and visited at home. Participants were tested using fasting blood glucose (FBG) measurements. DM was diagnosed as FBG ≥ 7 mmol/l. Our survey was linked to the patient database at the only existing Diabetes Clinic in Bissau.

RESULTS: TB patients (n=110) were older than the controls (n=572) (35 vs 31 years; p=0.02), more often male (55% vs 37%; p<0.001) and had a lower body mass index (18.7 vs 24.2 kg/m(2); p<0.001). The prevalence of DM was 2.8% (3/107) for TB patients and 2.1% (11/531) for controls (p=0.64). Excluding two controls already receiving anti-diabetic treatment, the prevalence of DM was 2.8% (3/107) vs 1.7% (9/529) (p=0.44).

CONCLUSIONS: The prevalence of DM was low, also among TB patients. No association between DM and TB was found.

OriginalsprogEngelsk
TidsskriftTransactions of the Royal Society of Tropical Medicine and Hygiene
Vol/bind109
Udgave nummer6
Sider (fra-til)400-7
ISSN0035-9203
DOI
StatusUdgivet - jun. 2015

Fingeraftryk

Guinea-Bissau
Diabetes Mellitus
Population
Fasting
Databases
Body Mass Index

Citer dette

Haraldsdottir, Thorny L ; Rudolf, Frauke ; Bjerregaard-Andersen, Morten ; Joaquím, Luis Carlos ; Stochholm, Kirstine ; Gomes, Victor F ; Beck-Nielsen, Henning ; Ostergaard, Lars ; Aaby, Peter ; Wejse, Christian. / Diabetes mellitus prevalence in tuberculosis patients and the background population in Guinea-Bissau : a disease burden study from the capital Bissau. I: Transactions of the Royal Society of Tropical Medicine and Hygiene. 2015 ; Bind 109, Nr. 6. s. 400-7.
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title = "Diabetes mellitus prevalence in tuberculosis patients and the background population in Guinea-Bissau: a disease burden study from the capital Bissau",
abstract = "BACKGROUND: Data regarding the association between diabetes mellitus (DM) and tuberculosis (TB) in Africa are scare. We did a DM screening survey among TB patients and non-TB controls in Guinea-Bissau.METHODS: The study was conducted at the Bandim Health Project (BHP) in the capital Bissau. From July 2010 to July 2011, newly diagnosed TB cases were identified through a TB notification system. Concurrently, non-TB controls were selected randomly from the BHP's demographic surveillance database and visited at home. Participants were tested using fasting blood glucose (FBG) measurements. DM was diagnosed as FBG ≥ 7 mmol/l. Our survey was linked to the patient database at the only existing Diabetes Clinic in Bissau.RESULTS: TB patients (n=110) were older than the controls (n=572) (35 vs 31 years; p=0.02), more often male (55{\%} vs 37{\%}; p<0.001) and had a lower body mass index (18.7 vs 24.2 kg/m(2); p<0.001). The prevalence of DM was 2.8{\%} (3/107) for TB patients and 2.1{\%} (11/531) for controls (p=0.64). Excluding two controls already receiving anti-diabetic treatment, the prevalence of DM was 2.8{\%} (3/107) vs 1.7{\%} (9/529) (p=0.44).CONCLUSIONS: The prevalence of DM was low, also among TB patients. No association between DM and TB was found.",
author = "Haraldsdottir, {Thorny L} and Frauke Rudolf and Morten Bjerregaard-Andersen and Joaqu{\'i}m, {Luis Carlos} and Kirstine Stochholm and Gomes, {Victor F} and Henning Beck-Nielsen and Lars Ostergaard and Peter Aaby and Christian Wejse",
note = "{\circledC} The Author 2015. Published by Oxford University Press on behalf of Royal Society of Tropical Medicine and Hygiene. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.",
year = "2015",
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volume = "109",
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Diabetes mellitus prevalence in tuberculosis patients and the background population in Guinea-Bissau : a disease burden study from the capital Bissau. / Haraldsdottir, Thorny L; Rudolf, Frauke; Bjerregaard-Andersen, Morten; Joaquím, Luis Carlos; Stochholm, Kirstine; Gomes, Victor F; Beck-Nielsen, Henning; Ostergaard, Lars; Aaby, Peter; Wejse, Christian.

I: Transactions of the Royal Society of Tropical Medicine and Hygiene, Bind 109, Nr. 6, 06.2015, s. 400-7.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Diabetes mellitus prevalence in tuberculosis patients and the background population in Guinea-Bissau

T2 - a disease burden study from the capital Bissau

AU - Haraldsdottir, Thorny L

AU - Rudolf, Frauke

AU - Bjerregaard-Andersen, Morten

AU - Joaquím, Luis Carlos

AU - Stochholm, Kirstine

AU - Gomes, Victor F

AU - Beck-Nielsen, Henning

AU - Ostergaard, Lars

AU - Aaby, Peter

AU - Wejse, Christian

N1 - © The Author 2015. Published by Oxford University Press on behalf of Royal Society of Tropical Medicine and Hygiene. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

PY - 2015/6

Y1 - 2015/6

N2 - BACKGROUND: Data regarding the association between diabetes mellitus (DM) and tuberculosis (TB) in Africa are scare. We did a DM screening survey among TB patients and non-TB controls in Guinea-Bissau.METHODS: The study was conducted at the Bandim Health Project (BHP) in the capital Bissau. From July 2010 to July 2011, newly diagnosed TB cases were identified through a TB notification system. Concurrently, non-TB controls were selected randomly from the BHP's demographic surveillance database and visited at home. Participants were tested using fasting blood glucose (FBG) measurements. DM was diagnosed as FBG ≥ 7 mmol/l. Our survey was linked to the patient database at the only existing Diabetes Clinic in Bissau.RESULTS: TB patients (n=110) were older than the controls (n=572) (35 vs 31 years; p=0.02), more often male (55% vs 37%; p<0.001) and had a lower body mass index (18.7 vs 24.2 kg/m(2); p<0.001). The prevalence of DM was 2.8% (3/107) for TB patients and 2.1% (11/531) for controls (p=0.64). Excluding two controls already receiving anti-diabetic treatment, the prevalence of DM was 2.8% (3/107) vs 1.7% (9/529) (p=0.44).CONCLUSIONS: The prevalence of DM was low, also among TB patients. No association between DM and TB was found.

AB - BACKGROUND: Data regarding the association between diabetes mellitus (DM) and tuberculosis (TB) in Africa are scare. We did a DM screening survey among TB patients and non-TB controls in Guinea-Bissau.METHODS: The study was conducted at the Bandim Health Project (BHP) in the capital Bissau. From July 2010 to July 2011, newly diagnosed TB cases were identified through a TB notification system. Concurrently, non-TB controls were selected randomly from the BHP's demographic surveillance database and visited at home. Participants were tested using fasting blood glucose (FBG) measurements. DM was diagnosed as FBG ≥ 7 mmol/l. Our survey was linked to the patient database at the only existing Diabetes Clinic in Bissau.RESULTS: TB patients (n=110) were older than the controls (n=572) (35 vs 31 years; p=0.02), more often male (55% vs 37%; p<0.001) and had a lower body mass index (18.7 vs 24.2 kg/m(2); p<0.001). The prevalence of DM was 2.8% (3/107) for TB patients and 2.1% (11/531) for controls (p=0.64). Excluding two controls already receiving anti-diabetic treatment, the prevalence of DM was 2.8% (3/107) vs 1.7% (9/529) (p=0.44).CONCLUSIONS: The prevalence of DM was low, also among TB patients. No association between DM and TB was found.

U2 - 10.1093/trstmh/trv030

DO - 10.1093/trstmh/trv030

M3 - Journal article

C2 - 25918218

VL - 109

SP - 400

EP - 407

JO - Transactions of the Royal Society of Tropical Medicine and Hygiene

JF - Transactions of the Royal Society of Tropical Medicine and Hygiene

SN - 0035-9203

IS - 6

ER -