Diabetes mellitus and impaired fasting glucose in ART-naïve patients with HIV-1, HIV-2 and HIV-1/2 dual infection in Guinea-Bissau: a cross-sectional study

Ditte Steiniche, Sanne Jespersen, Christian Erikstrup, Henrik Krarup, Aase Handberg, Lars Østergaard, Thorny L Haraldsdottir, Candida Medina, Faustino Gomes Correira, Alex Lund Laursen, Morten Bjerregaard-Andersen, Christian Wejse, Bo Langhoff Hønge, Bissau HIV Cohort Study Group

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

BACKGROUND: The prevalence of diabetes mellitus (DM) is expected to increase in sub-Saharan Africa. Patients with HIV are at particular risk. We investigated the DM burden among antiretroviral therapy (ART)-naïve patients with HIV in Guinea-Bissau.

METHODS: Patients were consecutively included. Demographic and lifestyle data were collected and one fasting blood glucose (FBG) measurement was used to diagnose DM (FBG≥7.0 mmol/L) and impaired fasting glucose (IFG) (FBG≥6.1 and <7.0 mmol/L).

RESULTS: By June 2015, 953 newly diagnosed ART-naïve patients with HIV had been included in the study of whom 893 (93.7%) were fasting at the time of inclusion. Median age among the fasting patients was 37 years (IQR 30-46 years) and 562 (62.9%) were women. The prevalence of DM was 5.8% (52/893) while 5.6% (50/893) had IFG. DM was associated with family history of DM (OR 3.92, 95% CI 1.78 to 8.63), being 41-50 years (OR 2.98, 95% CI 1.18 to 7.49) or older than 50 years (OR 3.14, 95% CI 1.09 to 9.07) and Fula ethnicity (OR 2.72, 95% CI 1.12 to 6.62).

CONCLUSIONS: DM prevalence was higher among younger patients compared with the background population in Bissau. Traditional risk factors for DM such as advancing age and a family history of DM apply also for ART-naïve patients with HIV.

OriginalsprogEngelsk
TidsskriftTransactions of the Royal Society of Tropical Medicine and Hygiene
Vol/bind110
Udgave nummer4
Sider (fra-til)219-227
ISSN0035-9203
DOI
StatusUdgivet - 2016

Fingeraftryk

Guinea-Bissau
HIV-2
HIV-1
Fasting
Diabetes Mellitus
Cross-Sectional Studies
HIV
Africa South of the Sahara

Citer dette

Steiniche, Ditte ; Jespersen, Sanne ; Erikstrup, Christian ; Krarup, Henrik ; Handberg, Aase ; Østergaard, Lars ; Haraldsdottir, Thorny L ; Medina, Candida ; Gomes Correira, Faustino ; Laursen, Alex Lund ; Bjerregaard-Andersen, Morten ; Wejse, Christian ; Hønge, Bo Langhoff ; Bissau HIV Cohort Study Group. / Diabetes mellitus and impaired fasting glucose in ART-naïve patients with HIV-1, HIV-2 and HIV-1/2 dual infection in Guinea-Bissau : a cross-sectional study. I: Transactions of the Royal Society of Tropical Medicine and Hygiene. 2016 ; Bind 110, Nr. 4. s. 219-227.
@article{e03ccf6294fc4c48bd583e9c6f26aac0,
title = "Diabetes mellitus and impaired fasting glucose in ART-na{\"i}ve patients with HIV-1, HIV-2 and HIV-1/2 dual infection in Guinea-Bissau: a cross-sectional study",
abstract = "BACKGROUND: The prevalence of diabetes mellitus (DM) is expected to increase in sub-Saharan Africa. Patients with HIV are at particular risk. We investigated the DM burden among antiretroviral therapy (ART)-na{\"i}ve patients with HIV in Guinea-Bissau.METHODS: Patients were consecutively included. Demographic and lifestyle data were collected and one fasting blood glucose (FBG) measurement was used to diagnose DM (FBG≥7.0 mmol/L) and impaired fasting glucose (IFG) (FBG≥6.1 and <7.0 mmol/L).RESULTS: By June 2015, 953 newly diagnosed ART-na{\"i}ve patients with HIV had been included in the study of whom 893 (93.7{\%}) were fasting at the time of inclusion. Median age among the fasting patients was 37 years (IQR 30-46 years) and 562 (62.9{\%}) were women. The prevalence of DM was 5.8{\%} (52/893) while 5.6{\%} (50/893) had IFG. DM was associated with family history of DM (OR 3.92, 95{\%} CI 1.78 to 8.63), being 41-50 years (OR 2.98, 95{\%} CI 1.18 to 7.49) or older than 50 years (OR 3.14, 95{\%} CI 1.09 to 9.07) and Fula ethnicity (OR 2.72, 95{\%} CI 1.12 to 6.62).CONCLUSIONS: DM prevalence was higher among younger patients compared with the background population in Bissau. Traditional risk factors for DM such as advancing age and a family history of DM apply also for ART-na{\"i}ve patients with HIV.",
keywords = "Adult, Age Factors, Anti-HIV Agents, Blood Glucose, Cross-Sectional Studies, Diabetes Complications, Diabetes Mellitus, Ethnic Groups, Family, Fasting, Female, Glucose Intolerance, Guinea-Bissau, HIV Infections, HIV-1, HIV-2, Humans, Male, Middle Aged, Odds Ratio, Prevalence, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't",
author = "Ditte Steiniche and Sanne Jespersen and Christian Erikstrup and Henrik Krarup and Aase Handberg and Lars {\O}stergaard and Haraldsdottir, {Thorny L} and Candida Medina and {Gomes Correira}, Faustino and Laursen, {Alex Lund} and Morten Bjerregaard-Andersen and Christian Wejse and H{\o}nge, {Bo Langhoff} and {Bissau HIV Cohort Study Group}",
note = "{\circledC} The Author 2016. Published by Oxford University Press on behalf of Royal Society of Tropical Medicine and Hygiene. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.",
year = "2016",
doi = "10.1093/trstmh/trw017",
language = "English",
volume = "110",
pages = "219--227",
journal = "Transactions of the Royal Society of Tropical Medicine and Hygiene",
issn = "0035-9203",
publisher = "Heinemann",
number = "4",

}

Steiniche, D, Jespersen, S, Erikstrup, C, Krarup, H, Handberg, A, Østergaard, L, Haraldsdottir, TL, Medina, C, Gomes Correira, F, Laursen, AL, Bjerregaard-Andersen, M, Wejse, C, Hønge, BL & Bissau HIV Cohort Study Group 2016, 'Diabetes mellitus and impaired fasting glucose in ART-naïve patients with HIV-1, HIV-2 and HIV-1/2 dual infection in Guinea-Bissau: a cross-sectional study', Transactions of the Royal Society of Tropical Medicine and Hygiene, bind 110, nr. 4, s. 219-227. https://doi.org/10.1093/trstmh/trw017

Diabetes mellitus and impaired fasting glucose in ART-naïve patients with HIV-1, HIV-2 and HIV-1/2 dual infection in Guinea-Bissau : a cross-sectional study. / Steiniche, Ditte; Jespersen, Sanne; Erikstrup, Christian; Krarup, Henrik; Handberg, Aase; Østergaard, Lars; Haraldsdottir, Thorny L; Medina, Candida; Gomes Correira, Faustino; Laursen, Alex Lund; Bjerregaard-Andersen, Morten; Wejse, Christian; Hønge, Bo Langhoff; Bissau HIV Cohort Study Group.

I: Transactions of the Royal Society of Tropical Medicine and Hygiene, Bind 110, Nr. 4, 2016, s. 219-227.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Diabetes mellitus and impaired fasting glucose in ART-naïve patients with HIV-1, HIV-2 and HIV-1/2 dual infection in Guinea-Bissau

T2 - a cross-sectional study

AU - Steiniche, Ditte

AU - Jespersen, Sanne

AU - Erikstrup, Christian

AU - Krarup, Henrik

AU - Handberg, Aase

AU - Østergaard, Lars

AU - Haraldsdottir, Thorny L

AU - Medina, Candida

AU - Gomes Correira, Faustino

AU - Laursen, Alex Lund

AU - Bjerregaard-Andersen, Morten

AU - Wejse, Christian

AU - Hønge, Bo Langhoff

AU - Bissau HIV Cohort Study Group

N1 - © The Author 2016. Published by Oxford University Press on behalf of Royal Society of Tropical Medicine and Hygiene. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

PY - 2016

Y1 - 2016

N2 - BACKGROUND: The prevalence of diabetes mellitus (DM) is expected to increase in sub-Saharan Africa. Patients with HIV are at particular risk. We investigated the DM burden among antiretroviral therapy (ART)-naïve patients with HIV in Guinea-Bissau.METHODS: Patients were consecutively included. Demographic and lifestyle data were collected and one fasting blood glucose (FBG) measurement was used to diagnose DM (FBG≥7.0 mmol/L) and impaired fasting glucose (IFG) (FBG≥6.1 and <7.0 mmol/L).RESULTS: By June 2015, 953 newly diagnosed ART-naïve patients with HIV had been included in the study of whom 893 (93.7%) were fasting at the time of inclusion. Median age among the fasting patients was 37 years (IQR 30-46 years) and 562 (62.9%) were women. The prevalence of DM was 5.8% (52/893) while 5.6% (50/893) had IFG. DM was associated with family history of DM (OR 3.92, 95% CI 1.78 to 8.63), being 41-50 years (OR 2.98, 95% CI 1.18 to 7.49) or older than 50 years (OR 3.14, 95% CI 1.09 to 9.07) and Fula ethnicity (OR 2.72, 95% CI 1.12 to 6.62).CONCLUSIONS: DM prevalence was higher among younger patients compared with the background population in Bissau. Traditional risk factors for DM such as advancing age and a family history of DM apply also for ART-naïve patients with HIV.

AB - BACKGROUND: The prevalence of diabetes mellitus (DM) is expected to increase in sub-Saharan Africa. Patients with HIV are at particular risk. We investigated the DM burden among antiretroviral therapy (ART)-naïve patients with HIV in Guinea-Bissau.METHODS: Patients were consecutively included. Demographic and lifestyle data were collected and one fasting blood glucose (FBG) measurement was used to diagnose DM (FBG≥7.0 mmol/L) and impaired fasting glucose (IFG) (FBG≥6.1 and <7.0 mmol/L).RESULTS: By June 2015, 953 newly diagnosed ART-naïve patients with HIV had been included in the study of whom 893 (93.7%) were fasting at the time of inclusion. Median age among the fasting patients was 37 years (IQR 30-46 years) and 562 (62.9%) were women. The prevalence of DM was 5.8% (52/893) while 5.6% (50/893) had IFG. DM was associated with family history of DM (OR 3.92, 95% CI 1.78 to 8.63), being 41-50 years (OR 2.98, 95% CI 1.18 to 7.49) or older than 50 years (OR 3.14, 95% CI 1.09 to 9.07) and Fula ethnicity (OR 2.72, 95% CI 1.12 to 6.62).CONCLUSIONS: DM prevalence was higher among younger patients compared with the background population in Bissau. Traditional risk factors for DM such as advancing age and a family history of DM apply also for ART-naïve patients with HIV.

KW - Adult

KW - Age Factors

KW - Anti-HIV Agents

KW - Blood Glucose

KW - Cross-Sectional Studies

KW - Diabetes Complications

KW - Diabetes Mellitus

KW - Ethnic Groups

KW - Family

KW - Fasting

KW - Female

KW - Glucose Intolerance

KW - Guinea-Bissau

KW - HIV Infections

KW - HIV-1

KW - HIV-2

KW - Humans

KW - Male

KW - Middle Aged

KW - Odds Ratio

KW - Prevalence

KW - Journal Article

KW - Research Support, N.I.H., Extramural

KW - Research Support, Non-U.S. Gov't

U2 - 10.1093/trstmh/trw017

DO - 10.1093/trstmh/trw017

M3 - Journal article

C2 - 27076509

VL - 110

SP - 219

EP - 227

JO - Transactions of the Royal Society of Tropical Medicine and Hygiene

JF - Transactions of the Royal Society of Tropical Medicine and Hygiene

SN - 0035-9203

IS - 4

ER -