Development of atopic dermatitis in the DARC birth cohort

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Udgivelsesdato: 2009-Sep-24
OriginalsprogEngelsk
TidsskriftPediatric Allergy and Immunology
Vol/bind21
Sider (fra-til)307-314
ISSN0905-6157
DOI
StatusUdgivet - 24. sep. 2009

Fingeraftryk

Atopic Dermatitis
Food Hypersensitivity
Eczema
Nuclear Family
Allergens
Hypersensitivity
Diet
Food

Citer dette

@article{b97246c0d9d111deb0fe000ea68e967b,
title = "Development of atopic dermatitis in the DARC birth cohort",
abstract = "Eller E, Kjaer HF, H{\o}st A, Andersen KE, Bindslev-Jensen C. Development of Atopic Dermatitis in the DARC birth cohort. Pediatr Allergy Immunol 2009. (c) 2009 John Wiley & Sons A/SThe aim was to describe the relapsing pattern, sensitization and prognosis of atopic dermatitis (AD) in the first 6 yr in a population-based, prospective birth cohort. The DARC cohort includes 562 children with clinical examinations, specific-IgE and skin prick test at all follow-ups. All children were examined for the development of AD using Hanifin-Rajka criteria and for food hypersensitivity by oral challenges. Severity of AD was measured by objective SCORing Atopic Dermatitis (SCORAD). Point-prevalence of AD peaked at 18 months of age (10{\%}) and decreased at 36 and 72 months to slightly below 7{\%}. The 6-yr cumulative incidence was 22.8{\%} and sensitization was found in 43{\%} of children with AD. It was predominately sensitization to foods, however shifting toward inhalant allergens with age. Sensitization at >/=2 follow-ups affected severity, whereas short-term sensitization at one follow-up does not. Children with early, non-IgE mediated (intrinsic) AD outgrew more often their eczema; however if they develop persistent AD, they remain intrinsic. Early long-term sensitization worsens the prognosis, but 38{\%} of all children have a debut later than 18 months of age. Boys had earlier onset of AD than girls. The large number of follow-ups gives a detailed picture of the relapsing pattern and shows that the relapses occur independently of time of onset. We could not establish any clear correlation between elimination diets and AD duration nor severity.",
author = "Esben Eller and Kjaer, {Henrik Fomsgaard} and Arne H{\o}st and Andersen, {Klaus Ejner} and Carsten Bindslev-Jensen",
year = "2009",
month = "9",
day = "24",
doi = "10.1111/j.1399-3038.2009.00914.x",
language = "English",
volume = "21",
pages = "307--314",
journal = "Pediatric Allergy and Immunology",
issn = "0905-6157",
publisher = "Wiley-Blackwell",

}

Development of atopic dermatitis in the DARC birth cohort. / Eller, Esben; Kjaer, Henrik Fomsgaard; Høst, Arne; Andersen, Klaus Ejner; Bindslev-Jensen, Carsten.

I: Pediatric Allergy and Immunology, Bind 21, 24.09.2009, s. 307-314.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Development of atopic dermatitis in the DARC birth cohort

AU - Eller, Esben

AU - Kjaer, Henrik Fomsgaard

AU - Høst, Arne

AU - Andersen, Klaus Ejner

AU - Bindslev-Jensen, Carsten

PY - 2009/9/24

Y1 - 2009/9/24

N2 - Eller E, Kjaer HF, Høst A, Andersen KE, Bindslev-Jensen C. Development of Atopic Dermatitis in the DARC birth cohort. Pediatr Allergy Immunol 2009. (c) 2009 John Wiley & Sons A/SThe aim was to describe the relapsing pattern, sensitization and prognosis of atopic dermatitis (AD) in the first 6 yr in a population-based, prospective birth cohort. The DARC cohort includes 562 children with clinical examinations, specific-IgE and skin prick test at all follow-ups. All children were examined for the development of AD using Hanifin-Rajka criteria and for food hypersensitivity by oral challenges. Severity of AD was measured by objective SCORing Atopic Dermatitis (SCORAD). Point-prevalence of AD peaked at 18 months of age (10%) and decreased at 36 and 72 months to slightly below 7%. The 6-yr cumulative incidence was 22.8% and sensitization was found in 43% of children with AD. It was predominately sensitization to foods, however shifting toward inhalant allergens with age. Sensitization at >/=2 follow-ups affected severity, whereas short-term sensitization at one follow-up does not. Children with early, non-IgE mediated (intrinsic) AD outgrew more often their eczema; however if they develop persistent AD, they remain intrinsic. Early long-term sensitization worsens the prognosis, but 38% of all children have a debut later than 18 months of age. Boys had earlier onset of AD than girls. The large number of follow-ups gives a detailed picture of the relapsing pattern and shows that the relapses occur independently of time of onset. We could not establish any clear correlation between elimination diets and AD duration nor severity.

AB - Eller E, Kjaer HF, Høst A, Andersen KE, Bindslev-Jensen C. Development of Atopic Dermatitis in the DARC birth cohort. Pediatr Allergy Immunol 2009. (c) 2009 John Wiley & Sons A/SThe aim was to describe the relapsing pattern, sensitization and prognosis of atopic dermatitis (AD) in the first 6 yr in a population-based, prospective birth cohort. The DARC cohort includes 562 children with clinical examinations, specific-IgE and skin prick test at all follow-ups. All children were examined for the development of AD using Hanifin-Rajka criteria and for food hypersensitivity by oral challenges. Severity of AD was measured by objective SCORing Atopic Dermatitis (SCORAD). Point-prevalence of AD peaked at 18 months of age (10%) and decreased at 36 and 72 months to slightly below 7%. The 6-yr cumulative incidence was 22.8% and sensitization was found in 43% of children with AD. It was predominately sensitization to foods, however shifting toward inhalant allergens with age. Sensitization at >/=2 follow-ups affected severity, whereas short-term sensitization at one follow-up does not. Children with early, non-IgE mediated (intrinsic) AD outgrew more often their eczema; however if they develop persistent AD, they remain intrinsic. Early long-term sensitization worsens the prognosis, but 38% of all children have a debut later than 18 months of age. Boys had earlier onset of AD than girls. The large number of follow-ups gives a detailed picture of the relapsing pattern and shows that the relapses occur independently of time of onset. We could not establish any clear correlation between elimination diets and AD duration nor severity.

U2 - 10.1111/j.1399-3038.2009.00914.x

DO - 10.1111/j.1399-3038.2009.00914.x

M3 - Journal article

VL - 21

SP - 307

EP - 314

JO - Pediatric Allergy and Immunology

JF - Pediatric Allergy and Immunology

SN - 0905-6157

ER -