Determination of rheumatoid factors by ELISA

Nicole Hartwig Trier*, Gunnar Houen

*Kontaktforfatter for dette arbejde

Publikation: Kapitel i bog/rapport/konference-proceedingKapitel i bogForskningpeer review

Abstrakt

IgM and IgA autoantibodies binding to IgG are called rheumatoid factors (RFs) and occur with high frequency in rheumatoid arthritis (RA) and with lower frequency in other autoimmune diseases. RFs have diagnostic and prognostic value in RA, but they also have a high potential to cause false positive reactions in other immunoassays, especially sandwich assays. For these reasons it is imperative to be able to measure RFs in serum samples from patients suspected of RA or other autoimmune diseases and in serum samples to be analyzed by sandwich immunoassay for various clinical parameters. Here, a simple ELISA for IgM and IgA RFs is described.

OriginalsprogEngelsk
TitelAutoantibodies : Methods and Protocols
RedaktørerGunnar Houen
Vol/bind1901
ForlagHumana Press
Publikationsdato1. jan. 2019
Sider263-270
ISBN (Trykt)978-1-4939-8948-5
ISBN (Elektronisk)978-1-4939-8949-2
DOI
StatusUdgivet - 1. jan. 2019
NavnMethods in Molecular Biology
Vol/bind1901
ISSN1064-3745

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