Determinants of new-onset and persistence of adult asthma in Denmark

Lars Rauff Skadhauge, Jesper Rømhild Davidsen, Øyvind Omland, Vivi Schlünssen, David Sherson, Torben Sigsgaard, Trine Thilsing, Jesper Baelum

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Abstrakt

Introduction: Asthma in adults has huge impact on social and working life. Identification of determinants associated with the incidence and course of the disease has public health implications.Objectives: Determinants associated with incidence and persistence of asthma were evaluated in a population-based sample of young adults.Methods: In a random sample of young adults (20 - 44 years) a cohort of 7,256 subjects (73%) responded a screening questionnaire in 2003. A total of 5,043 subjects (70%) responded the follow-up questionnaire in 2010. Current asthma was defined by self-reported ever asthma plus an asthma attack within the last 12 months and/or current use of asthma medication. Remission of asthma at follow-up was defined by neither having asthma attack, nor current use of asthma medication. Logistic regression was used to identify determinants related to incidence and persistence of asthma during follow-up.Results: A total of 184 incident cases of asthma were identified at follow-up. Nearly one third of 287 prevalent cases at baseline experienced remission of asthma during follow-up. Determinants associated with new-onset asthma were female sex (OR 1.40; 95%CI: 1.02-1.90), nasal allergy (OR 2.91; 2.15-3.95), family history of asthma (OR 1.82; 1.27-2.61) and current smoking (OR 1.59, 1.11-2.27) at baseline. The only determinant of persistent asthma was increasing age in females (OR 1.09; 1.04-1.14). No significant determinants for remission were observed.Conclusions: Clinical, demographic and environmental factors were determinants for developing asthma in adults. Increasing age in females was the only risk factor for persistent asthma. Remission of the disease was common, but no determinants were identified.
OriginalsprogEngelsk
ArtikelnummerPA3383
TidsskriftEuropean Respiratory Journal
Vol/bind46
Udgave nummersuppl 59
ISSN0903-1936
DOI
StatusUdgivet - 1. sep. 2015

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