Dermatomyositis and Polymyositis

Louise C. Pyndt Raun Diederichsen*, Helga Sanner, Ivar Sjaastad, Ingrid E Lundberg

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Abstrakt

Idiopathic inflammatory myopathies (IIMs), collectively called myositis, are a heterogeneous group of diseases affecting adults and children. The IIMs are characterized by symmetrical, proximal muscle weakness and by inflammatory infiltrates in skeletal muscles. Based on differences in clinical and histopathological features, they can be divided into different subgroups, the most common forms being dermatomyositis (DM), polymyositis (PM), sporadic inclusion body myositis (sIBM), and in children juvenile dermatomyositis (JDM). Other organs are frequently involved in patients with IIM eg, lungs, gastrointestinal tract, and the heart, emphasizing that these are systemic inflammatory diseases. IIMs are associated with increased mortality, and cardiovascular involvement has been recognized as the main prognostic factor for death. Processes affecting the heart in IIM include coronary artery disease and cardiac affection caused by inflammation. In this chapter, we focus on adult PM and DM and JDM as little is known about cardiac involvement in the other subsets.

OriginalsprogEngelsk
TitelThe Heart in Rheumatic, Autoimmune and Inflammatory Diseases : Pathophysiology, Clinical Aspects and Therapeutic Approaches
RedaktørerUdi Nussinovitch
ForlagAcademic Press
Publikationsdato2017
Sider327-346
Kapitel14
ISBN (Trykt)9780128032671
ISBN (Elektronisk)9780128032688
DOI
StatusUdgivet - 2017

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Citationsformater

Diederichsen, L. C. P. R., Sanner, H., Sjaastad, I., & Lundberg, I. E. (2017). Dermatomyositis and Polymyositis. I U. Nussinovitch (red.), The Heart in Rheumatic, Autoimmune and Inflammatory Diseases: Pathophysiology, Clinical Aspects and Therapeutic Approaches (s. 327-346). Academic Press. https://doi.org/10.1016/B978-0-12-803267-1.00014-4