Depth of neutrophil nadir after first cycle of R-CHOP predicts outcome in diffuse large B-cell lymphoma–a nationwide population-based cohort study

Michael Roost Clausen*, Sinna Pilgaard Ulrichsen, Thomas Stauffer Larsen, Christian B. Poulsen, Selma Tojaga, Per Trøllund Pedersen, Jakob Madsen, Robert Schou Pedersen, Pär Lars Josefsson, Jette Sønderskov Gørløv, Mette Nørgaard, Francesco d’Amore

*Kontaktforfatter for dette arbejde

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

We investigated if survival was predicted by nadir neutrophil counts after the first cycle of R-CHOP in patients with newly diagnosed diffuse large B-cell lymphoma (DLBCL). Neutrophil counts (109/L) were categorized in four grades in the nadir time frame. Prognostic indices and comorbidity levels were calculated and used to adjust the Cox regression model. Kaplan–Meier and Cox regression methods were used to estimate and compare survival. We identified 965 patients. Grade 4 neutropenia was present in 432 (45%). Grade 0 patients had a 5-year overall survival of 67%, grade 1–2: 78%, grade 3: 64%, and grade 4: 57%. Compared with grade 0 adjusted hazard ratios (HR) for death were: 0.77 (95% CI 0.49–1.21) for grade 1–2, 1.18 (95% CI 0.82–1.71) for grade 3, and 1.33 (95% CI 1.02–1.73) for grade 4. Grade 4 neutropenia after the 1st cycle of chemotherapy predicted inferior outcome compared with grade 0 and 1–2. Grade 1–2 neutropenia seemed to have superior outcome.

OriginalsprogEngelsk
TidsskriftLeukemia and Lymphoma
Vol/bind60
Udgave nummer8
Sider (fra-til)1950-1957
ISSN1042-8194
DOI
StatusUdgivet - 3. jul. 2019

Fingeraftryk

Neutropenia
Neutrophils
Cohort Studies
Population
Lymphoma, Large B-Cell, Diffuse
Proportional Hazards Models
Comorbidity

Citer dette

Clausen, Michael Roost ; Ulrichsen, Sinna Pilgaard ; Larsen, Thomas Stauffer ; Poulsen, Christian B. ; Tojaga, Selma ; Pedersen, Per Trøllund ; Madsen, Jakob ; Pedersen, Robert Schou ; Josefsson, Pär Lars ; Gørløv, Jette Sønderskov ; Nørgaard, Mette ; d’Amore, Francesco. / Depth of neutrophil nadir after first cycle of R-CHOP predicts outcome in diffuse large B-cell lymphoma–a nationwide population-based cohort study. I: Leukemia and Lymphoma. 2019 ; Bind 60, Nr. 8. s. 1950-1957.
@article{5f75fced8f794af1a294625182d2f059,
title = "Depth of neutrophil nadir after first cycle of R-CHOP predicts outcome in diffuse large B-cell lymphoma–a nationwide population-based cohort study",
abstract = "We investigated if survival was predicted by nadir neutrophil counts after the first cycle of R-CHOP in patients with newly diagnosed diffuse large B-cell lymphoma (DLBCL). Neutrophil counts (109/L) were categorized in four grades in the nadir time frame. Prognostic indices and comorbidity levels were calculated and used to adjust the Cox regression model. Kaplan–Meier and Cox regression methods were used to estimate and compare survival. We identified 965 patients. Grade 4 neutropenia was present in 432 (45{\%}). Grade 0 patients had a 5-year overall survival of 67{\%}, grade 1–2: 78{\%}, grade 3: 64{\%}, and grade 4: 57{\%}. Compared with grade 0 adjusted hazard ratios (HR) for death were: 0.77 (95{\%} CI 0.49–1.21) for grade 1–2, 1.18 (95{\%} CI 0.82–1.71) for grade 3, and 1.33 (95{\%} CI 1.02–1.73) for grade 4. Grade 4 neutropenia after the 1st cycle of chemotherapy predicted inferior outcome compared with grade 0 and 1–2. Grade 1–2 neutropenia seemed to have superior outcome.",
keywords = "Diffuse large B-cell lymphoma, neutropenia, prognosis",
author = "Clausen, {Michael Roost} and Ulrichsen, {Sinna Pilgaard} and Larsen, {Thomas Stauffer} and Poulsen, {Christian B.} and Selma Tojaga and Pedersen, {Per Tr{\o}llund} and Jakob Madsen and Pedersen, {Robert Schou} and Josefsson, {P{\"a}r Lars} and G{\o}rl{\o}v, {Jette S{\o}nderskov} and Mette N{\o}rgaard and Francesco d’Amore",
year = "2019",
month = "7",
day = "3",
doi = "10.1080/10428194.2018.1554863",
language = "English",
volume = "60",
pages = "1950--1957",
journal = "Leukemia and Lymphoma",
issn = "1042-8194",
publisher = "Taylor & Francis",
number = "8",

}

Clausen, MR, Ulrichsen, SP, Larsen, TS, Poulsen, CB, Tojaga, S, Pedersen, PT, Madsen, J, Pedersen, RS, Josefsson, PL, Gørløv, JS, Nørgaard, M & d’Amore, F 2019, 'Depth of neutrophil nadir after first cycle of R-CHOP predicts outcome in diffuse large B-cell lymphoma–a nationwide population-based cohort study', Leukemia and Lymphoma, bind 60, nr. 8, s. 1950-1957. https://doi.org/10.1080/10428194.2018.1554863

Depth of neutrophil nadir after first cycle of R-CHOP predicts outcome in diffuse large B-cell lymphoma–a nationwide population-based cohort study. / Clausen, Michael Roost; Ulrichsen, Sinna Pilgaard; Larsen, Thomas Stauffer; Poulsen, Christian B.; Tojaga, Selma; Pedersen, Per Trøllund; Madsen, Jakob; Pedersen, Robert Schou; Josefsson, Pär Lars; Gørløv, Jette Sønderskov; Nørgaard, Mette; d’Amore, Francesco.

I: Leukemia and Lymphoma, Bind 60, Nr. 8, 03.07.2019, s. 1950-1957.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Depth of neutrophil nadir after first cycle of R-CHOP predicts outcome in diffuse large B-cell lymphoma–a nationwide population-based cohort study

AU - Clausen, Michael Roost

AU - Ulrichsen, Sinna Pilgaard

AU - Larsen, Thomas Stauffer

AU - Poulsen, Christian B.

AU - Tojaga, Selma

AU - Pedersen, Per Trøllund

AU - Madsen, Jakob

AU - Pedersen, Robert Schou

AU - Josefsson, Pär Lars

AU - Gørløv, Jette Sønderskov

AU - Nørgaard, Mette

AU - d’Amore, Francesco

PY - 2019/7/3

Y1 - 2019/7/3

N2 - We investigated if survival was predicted by nadir neutrophil counts after the first cycle of R-CHOP in patients with newly diagnosed diffuse large B-cell lymphoma (DLBCL). Neutrophil counts (109/L) were categorized in four grades in the nadir time frame. Prognostic indices and comorbidity levels were calculated and used to adjust the Cox regression model. Kaplan–Meier and Cox regression methods were used to estimate and compare survival. We identified 965 patients. Grade 4 neutropenia was present in 432 (45%). Grade 0 patients had a 5-year overall survival of 67%, grade 1–2: 78%, grade 3: 64%, and grade 4: 57%. Compared with grade 0 adjusted hazard ratios (HR) for death were: 0.77 (95% CI 0.49–1.21) for grade 1–2, 1.18 (95% CI 0.82–1.71) for grade 3, and 1.33 (95% CI 1.02–1.73) for grade 4. Grade 4 neutropenia after the 1st cycle of chemotherapy predicted inferior outcome compared with grade 0 and 1–2. Grade 1–2 neutropenia seemed to have superior outcome.

AB - We investigated if survival was predicted by nadir neutrophil counts after the first cycle of R-CHOP in patients with newly diagnosed diffuse large B-cell lymphoma (DLBCL). Neutrophil counts (109/L) were categorized in four grades in the nadir time frame. Prognostic indices and comorbidity levels were calculated and used to adjust the Cox regression model. Kaplan–Meier and Cox regression methods were used to estimate and compare survival. We identified 965 patients. Grade 4 neutropenia was present in 432 (45%). Grade 0 patients had a 5-year overall survival of 67%, grade 1–2: 78%, grade 3: 64%, and grade 4: 57%. Compared with grade 0 adjusted hazard ratios (HR) for death were: 0.77 (95% CI 0.49–1.21) for grade 1–2, 1.18 (95% CI 0.82–1.71) for grade 3, and 1.33 (95% CI 1.02–1.73) for grade 4. Grade 4 neutropenia after the 1st cycle of chemotherapy predicted inferior outcome compared with grade 0 and 1–2. Grade 1–2 neutropenia seemed to have superior outcome.

KW - Diffuse large B-cell lymphoma

KW - neutropenia

KW - prognosis

U2 - 10.1080/10428194.2018.1554863

DO - 10.1080/10428194.2018.1554863

M3 - Journal article

C2 - 30668181

AN - SCOPUS:85060634799

VL - 60

SP - 1950

EP - 1957

JO - Leukemia and Lymphoma

JF - Leukemia and Lymphoma

SN - 1042-8194

IS - 8

ER -