Depression: a major, unrecognized risk factor for osteoporosis?

G Cizza, Pernille Ravn, G P Chrousos, P W Gold

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review


Existing studies of the relationship between depression and osteoporosis have been heterogeneous in their design and use of diagnostic instruments for depression, which might have contributed to the different results on the comorbidity of these two conditions. Nevertheless, these studies reveal a strong association between depression and osteoporosis. Endocrine factors such as depression-induced hypersecretion of corticotropin-releasing hormone and hypercortisolism, hypogonadism, growth hormone deficiency and increased concentration of circulating interleukin 6, might play a crucial role in the bone loss observed in subjects suffering from major depression.

TidsskriftTrends in Endocrinology and Metabolism
Udgave nummer5
Sider (fra-til)198-203
Antal sider6
StatusUdgivet - jul. 2001

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