Depression: a major, unrecognized risk factor for osteoporosis?

G Cizza, Pernille Ravn, G P Chrousos, P W Gold

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Abstrakt

Existing studies of the relationship between depression and osteoporosis have been heterogeneous in their design and use of diagnostic instruments for depression, which might have contributed to the different results on the comorbidity of these two conditions. Nevertheless, these studies reveal a strong association between depression and osteoporosis. Endocrine factors such as depression-induced hypersecretion of corticotropin-releasing hormone and hypercortisolism, hypogonadism, growth hormone deficiency and increased concentration of circulating interleukin 6, might play a crucial role in the bone loss observed in subjects suffering from major depression.

OriginalsprogEngelsk
TidsskriftTrends in Endocrinology and Metabolism
Vol/bind12
Udgave nummer5
Sider (fra-til)198-203
Antal sider6
ISSN1043-2760
StatusUdgivet - jul. 2001

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