Den prognostiske værdi af insulinlignende vækstfaktor I - IGF-I - og bindingsproteinet IGFBP-3 ved alkoholisk leversygdom

Søren Møller, Povl Ulrik Becker, Anders Juul, Niels E. Skakkebœk, Erik Christensen

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Prognostic value of insulin-like growth factor-I IGF-I - and its binding protein - IGFBP-3 - in patients with alcoholic liver disease. IGF-I is a single polypeptide chain with important anabolic and endocrine activities. The liver is the major source of IGF-I and its binding protein, IGFBP-3. Circulating concentrations of IGF-I and IGFBP-3 are decreased in patients with chronic liver disease and correlate with the severity. The aim of this study was to assess the additional prognostic value of IGF-I and IGFBP-3 in patients entered in a large multicentre study (EMALD). Three hundred and thirty-seven patients with alcoholic liver disease were studied in a randomised placebo-controlled trial of malotilate with a mean follow-up period of 569 days (range: 7-1544). A multivariate Cox regression analysis of pertinent clinical and biochemical variables revealed a significant independent prognostic value of years of alcohol intake, coagulation factors 2, 7, and 10, alkaline phosphatases, serum creatinine, and immunoglobulin M (IGM). When IGF-I or IGFBP-3 were added into this model, a Cox regression analysis showed that either had a significant independent prognostic value. As IGF-1 and IGFBP-3 were closely correlated, they contained almost the same prognostic information. Inclusion of IGF-I gave these results: IGF-I (p<0.03), alcohol intake (p<0.02), coagulation factors 2, 7, and 10 (p<0.01), creatinine (p<0.001), and IgM (p<0.01) contained independent prognostic information. Inclusion of IGFBP-3 gave these results: IGFBP-3 (p<0.02), alcohol intake (p<0.05), coagulation factor 2, 7, and 10 (p<0.01), creatinine (p<0.001), and IgM (p<0.02) were independent predictors of survival. In conclusion IGF-I or IGFBP-3 provides important additional information on survival in patients with alcoholic liver disease.

OriginalsprogDansk
TidsskriftUgeskrift for Laeger
Vol/bind159
Udgave nummer30
Sider (fra-til)4636-4640
Antal sider5
ISSN0041-5782
StatusUdgivet - 1. dec. 1997

Citer dette

Møller, Søren ; Becker, Povl Ulrik ; Juul, Anders ; Skakkebœk, Niels E. ; Christensen, Erik. / Den prognostiske værdi af insulinlignende vækstfaktor I - IGF-I - og bindingsproteinet IGFBP-3 ved alkoholisk leversygdom. I: Ugeskrift for Laeger. 1997 ; Bind 159, Nr. 30. s. 4636-4640.
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abstract = "Prognostic value of insulin-like growth factor-I IGF-I - and its binding protein - IGFBP-3 - in patients with alcoholic liver disease. IGF-I is a single polypeptide chain with important anabolic and endocrine activities. The liver is the major source of IGF-I and its binding protein, IGFBP-3. Circulating concentrations of IGF-I and IGFBP-3 are decreased in patients with chronic liver disease and correlate with the severity. The aim of this study was to assess the additional prognostic value of IGF-I and IGFBP-3 in patients entered in a large multicentre study (EMALD). Three hundred and thirty-seven patients with alcoholic liver disease were studied in a randomised placebo-controlled trial of malotilate with a mean follow-up period of 569 days (range: 7-1544). A multivariate Cox regression analysis of pertinent clinical and biochemical variables revealed a significant independent prognostic value of years of alcohol intake, coagulation factors 2, 7, and 10, alkaline phosphatases, serum creatinine, and immunoglobulin M (IGM). When IGF-I or IGFBP-3 were added into this model, a Cox regression analysis showed that either had a significant independent prognostic value. As IGF-1 and IGFBP-3 were closely correlated, they contained almost the same prognostic information. Inclusion of IGF-I gave these results: IGF-I (p<0.03), alcohol intake (p<0.02), coagulation factors 2, 7, and 10 (p<0.01), creatinine (p<0.001), and IgM (p<0.01) contained independent prognostic information. Inclusion of IGFBP-3 gave these results: IGFBP-3 (p<0.02), alcohol intake (p<0.05), coagulation factor 2, 7, and 10 (p<0.01), creatinine (p<0.001), and IgM (p<0.02) were independent predictors of survival. In conclusion IGF-I or IGFBP-3 provides important additional information on survival in patients with alcoholic liver disease.",
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Den prognostiske værdi af insulinlignende vækstfaktor I - IGF-I - og bindingsproteinet IGFBP-3 ved alkoholisk leversygdom. / Møller, Søren; Becker, Povl Ulrik; Juul, Anders; Skakkebœk, Niels E.; Christensen, Erik.

I: Ugeskrift for Laeger, Bind 159, Nr. 30, 01.12.1997, s. 4636-4640.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Den prognostiske værdi af insulinlignende vækstfaktor I - IGF-I - og bindingsproteinet IGFBP-3 ved alkoholisk leversygdom

AU - Møller, Søren

AU - Becker, Povl Ulrik

AU - Juul, Anders

AU - Skakkebœk, Niels E.

AU - Christensen, Erik

PY - 1997/12/1

Y1 - 1997/12/1

N2 - Prognostic value of insulin-like growth factor-I IGF-I - and its binding protein - IGFBP-3 - in patients with alcoholic liver disease. IGF-I is a single polypeptide chain with important anabolic and endocrine activities. The liver is the major source of IGF-I and its binding protein, IGFBP-3. Circulating concentrations of IGF-I and IGFBP-3 are decreased in patients with chronic liver disease and correlate with the severity. The aim of this study was to assess the additional prognostic value of IGF-I and IGFBP-3 in patients entered in a large multicentre study (EMALD). Three hundred and thirty-seven patients with alcoholic liver disease were studied in a randomised placebo-controlled trial of malotilate with a mean follow-up period of 569 days (range: 7-1544). A multivariate Cox regression analysis of pertinent clinical and biochemical variables revealed a significant independent prognostic value of years of alcohol intake, coagulation factors 2, 7, and 10, alkaline phosphatases, serum creatinine, and immunoglobulin M (IGM). When IGF-I or IGFBP-3 were added into this model, a Cox regression analysis showed that either had a significant independent prognostic value. As IGF-1 and IGFBP-3 were closely correlated, they contained almost the same prognostic information. Inclusion of IGF-I gave these results: IGF-I (p<0.03), alcohol intake (p<0.02), coagulation factors 2, 7, and 10 (p<0.01), creatinine (p<0.001), and IgM (p<0.01) contained independent prognostic information. Inclusion of IGFBP-3 gave these results: IGFBP-3 (p<0.02), alcohol intake (p<0.05), coagulation factor 2, 7, and 10 (p<0.01), creatinine (p<0.001), and IgM (p<0.02) were independent predictors of survival. In conclusion IGF-I or IGFBP-3 provides important additional information on survival in patients with alcoholic liver disease.

AB - Prognostic value of insulin-like growth factor-I IGF-I - and its binding protein - IGFBP-3 - in patients with alcoholic liver disease. IGF-I is a single polypeptide chain with important anabolic and endocrine activities. The liver is the major source of IGF-I and its binding protein, IGFBP-3. Circulating concentrations of IGF-I and IGFBP-3 are decreased in patients with chronic liver disease and correlate with the severity. The aim of this study was to assess the additional prognostic value of IGF-I and IGFBP-3 in patients entered in a large multicentre study (EMALD). Three hundred and thirty-seven patients with alcoholic liver disease were studied in a randomised placebo-controlled trial of malotilate with a mean follow-up period of 569 days (range: 7-1544). A multivariate Cox regression analysis of pertinent clinical and biochemical variables revealed a significant independent prognostic value of years of alcohol intake, coagulation factors 2, 7, and 10, alkaline phosphatases, serum creatinine, and immunoglobulin M (IGM). When IGF-I or IGFBP-3 were added into this model, a Cox regression analysis showed that either had a significant independent prognostic value. As IGF-1 and IGFBP-3 were closely correlated, they contained almost the same prognostic information. Inclusion of IGF-I gave these results: IGF-I (p<0.03), alcohol intake (p<0.02), coagulation factors 2, 7, and 10 (p<0.01), creatinine (p<0.001), and IgM (p<0.01) contained independent prognostic information. Inclusion of IGFBP-3 gave these results: IGFBP-3 (p<0.02), alcohol intake (p<0.05), coagulation factor 2, 7, and 10 (p<0.01), creatinine (p<0.001), and IgM (p<0.02) were independent predictors of survival. In conclusion IGF-I or IGFBP-3 provides important additional information on survival in patients with alcoholic liver disease.

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M3 - Tidsskriftartikel

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SP - 4636

EP - 4640

JO - Ugeskrift for Laeger

JF - Ugeskrift for Laeger

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