Demonstration of S-100 protein in sustentacular cells of phaeochromocytomas and paragangliomas

H D Schroder, L Johannsen

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Eighteen phaeochromocytomas, including both sporadic and familial cases, four cervical paragangliomas, two jugular paragangliomas, and one abdominal paraganglioma were examined immunohistochemically for the presence of S-100 protein. Positive staining in cells morphologically similar to the sustentacular cells of normal paraganglia and adrenal medulla were found in all paragangliomas and in the benign and aggressively growing phaeochromocytomas. In the two malignant tumours no positive reaction was demonstrated. In one tumour the sustentacular cells were shown to contain glial fibrillary acidic protein further supporting their Schwann cell relationship. The number of S-100 positive cells varied considerably. They demonstrated a spindle celled or elongated configuration with long slender processes. The nature of the sustentacular cell proliferation, neoplastic versus reactive, is discussed.

OriginalsprogEngelsk
TidsskriftHistopathology
Vol/bind10
Udgave nummer10
Sider (fra-til)1023-33
Antal sider11
ISSN0309-0167
StatusUdgivet - okt. 1986

Fingeraftryk

Paraganglioma
Pheochromocytoma
Adrenal Medulla
Schwann Cells
Glial Fibrillary Acidic Protein
Neoplasms
Cell Proliferation

Citer dette

@article{d0b9f5b92d834f0a81593505ce4bb9de,
title = "Demonstration of S-100 protein in sustentacular cells of phaeochromocytomas and paragangliomas",
abstract = "Eighteen phaeochromocytomas, including both sporadic and familial cases, four cervical paragangliomas, two jugular paragangliomas, and one abdominal paraganglioma were examined immunohistochemically for the presence of S-100 protein. Positive staining in cells morphologically similar to the sustentacular cells of normal paraganglia and adrenal medulla were found in all paragangliomas and in the benign and aggressively growing phaeochromocytomas. In the two malignant tumours no positive reaction was demonstrated. In one tumour the sustentacular cells were shown to contain glial fibrillary acidic protein further supporting their Schwann cell relationship. The number of S-100 positive cells varied considerably. They demonstrated a spindle celled or elongated configuration with long slender processes. The nature of the sustentacular cell proliferation, neoplastic versus reactive, is discussed.",
keywords = "Adolescent, Adrenal Gland Neoplasms, Adult, Aged, Female, Histocytochemistry, Humans, Immunoenzyme Techniques, Male, Middle Aged, Paraganglioma, Pheochromocytoma, S100 Proteins, Journal Article",
author = "Schroder, {H D} and L Johannsen",
year = "1986",
month = "10",
language = "English",
volume = "10",
pages = "1023--33",
journal = "Histopathology",
issn = "0309-0167",
publisher = "Wiley-Blackwell",
number = "10",

}

Demonstration of S-100 protein in sustentacular cells of phaeochromocytomas and paragangliomas. / Schroder, H D; Johannsen, L.

I: Histopathology, Bind 10, Nr. 10, 10.1986, s. 1023-33.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Demonstration of S-100 protein in sustentacular cells of phaeochromocytomas and paragangliomas

AU - Schroder, H D

AU - Johannsen, L

PY - 1986/10

Y1 - 1986/10

N2 - Eighteen phaeochromocytomas, including both sporadic and familial cases, four cervical paragangliomas, two jugular paragangliomas, and one abdominal paraganglioma were examined immunohistochemically for the presence of S-100 protein. Positive staining in cells morphologically similar to the sustentacular cells of normal paraganglia and adrenal medulla were found in all paragangliomas and in the benign and aggressively growing phaeochromocytomas. In the two malignant tumours no positive reaction was demonstrated. In one tumour the sustentacular cells were shown to contain glial fibrillary acidic protein further supporting their Schwann cell relationship. The number of S-100 positive cells varied considerably. They demonstrated a spindle celled or elongated configuration with long slender processes. The nature of the sustentacular cell proliferation, neoplastic versus reactive, is discussed.

AB - Eighteen phaeochromocytomas, including both sporadic and familial cases, four cervical paragangliomas, two jugular paragangliomas, and one abdominal paraganglioma were examined immunohistochemically for the presence of S-100 protein. Positive staining in cells morphologically similar to the sustentacular cells of normal paraganglia and adrenal medulla were found in all paragangliomas and in the benign and aggressively growing phaeochromocytomas. In the two malignant tumours no positive reaction was demonstrated. In one tumour the sustentacular cells were shown to contain glial fibrillary acidic protein further supporting their Schwann cell relationship. The number of S-100 positive cells varied considerably. They demonstrated a spindle celled or elongated configuration with long slender processes. The nature of the sustentacular cell proliferation, neoplastic versus reactive, is discussed.

KW - Adolescent

KW - Adrenal Gland Neoplasms

KW - Adult

KW - Aged

KW - Female

KW - Histocytochemistry

KW - Humans

KW - Immunoenzyme Techniques

KW - Male

KW - Middle Aged

KW - Paraganglioma

KW - Pheochromocytoma

KW - S100 Proteins

KW - Journal Article

M3 - Journal article

C2 - 3536711

VL - 10

SP - 1023

EP - 1033

JO - Histopathology

JF - Histopathology

SN - 0309-0167

IS - 10

ER -