Demographic and clinical features of neuromyelitis optica: A review

L. Pandit, Nasrin Asgari, M. Apiwattanakul, J. Palace, F. Paul, M. I. Leite, I. Kleiter, T. Chitnis

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Abstrakt

The comparative clinical and demographic features of neuromyelitis optica (NMO) are not well known. In this review we analyzed peer-reviewed publications for incidence and prevalence, clinical phenotypes, and demographic features of NMO. Population-based studies from Europe, South East and Southern Asia, the Caribbean, and Cuba suggest that the incidence and prevalence of NMO ranges from 0.05-0.4 and 0.52-4.4 per 100,000, respectively. Mean age at onset (32.6-45.7) and median time to first relapse (8-12 months) was similar. Most studies reported an excess of disease in women and a relapsing course, particularly in anti-aquaporin 4 antibody (anti AQP4-IgG)-positive patients. Ethnicity may have a bearing on disease phenotype and clinical outcome. Despite limitations inherent to the review process, themes noted in clinical and demographic features of NMO among different populations promote a more global understanding of NMO and strategies to address it.
OriginalsprogEngelsk
TidsskriftMultiple Sclerosis Journal
Vol/bind21
Udgave nummer7
Sider (fra-til)845-853
ISSN1352-4585
DOI
StatusUdgivet - 2015

Bibliografisk note

3 25921037

Emneord

  • NMO epidemiology demographics incidence prevalence EXTENSIVE TRANSVERSE MYELITIS MULTIPLE-SCLEROSIS PROGNOSTIC-FACTORS AQUAPORIN-4 AUTOIMMUNITY UNITED-KINGDOM MULTICENTER POPULATION SPECTRUM NMO DISORDERS

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