Dementia and road traffic accidents among non-institutionalized older people in Denmark

A Danish register-based nested case-control study

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Aim: We used register-based data to estimate the effect of all-type dementia on road traffic accidents (RTAs) risk, combined with comorbidities or sedative medicines, among non-institutionalized older people in Denmark. Methods: The source population was all residents in Denmark aged 65 years and older, alive as of January 1, 2008 (n = 853,228). Cases were those who had any type of RTA in 2009–2014. Each case was matched for age, sex and geographic location to 4–6 controls. All-type dementia was ascertained using the International Classification of Diseases version 10 (ICD-10) diagnosis supplemented with prescribed medicine records. Eight chronic diseases were selected to assess comorbidities. Four types of medicines were categorized as sedative medicines for analysis. Conditional logistic regression with adjustment for education and marital status as well as either the number of comorbidities or sedative medications use was performed using STATA software. Results: Older people with dementia had lower RTAs risk compared to their controls (odds ratio = 0.43, 95% confidence interval (0.32–0.60), p < 0.001). Significant interaction was observed between dementia and the number of comorbidities for RTAs estimation. Conclusions: The significantly lower RTAs risk for older individuals with dementia observed in our study may be due to people with dementia living at home having a lower frequency of outdoor activities; that is, less exposure to traffic. However, this, together with the interaction between dementia and comorbidities as well as sedative medications, should be investigated further.

OriginalsprogEngelsk
TidsskriftScandinavian Journal of Public Health
Vol/bind47
Udgave nummer2
Sider (fra-til)221-228
ISSN1403-4948
DOI
StatusUdgivet - 1. mar. 2019

Fingeraftryk

Traffic Accidents
Denmark
Case-Control Studies
Comorbidity
Hypnotics and Sedatives
Geographic Locations
Marital Status
International Classification of Diseases
Logistic Models
Odds Ratio
Confidence Intervals
Education
Population

Citer dette

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title = "Dementia and road traffic accidents among non-institutionalized older people in Denmark: A Danish register-based nested case-control study",
abstract = "Aim: We used register-based data to estimate the effect of all-type dementia on road traffic accidents (RTAs) risk, combined with comorbidities or sedative medicines, among non-institutionalized older people in Denmark. Methods: The source population was all residents in Denmark aged 65 years and older, alive as of January 1, 2008 (n = 853,228). Cases were those who had any type of RTA in 2009–2014. Each case was matched for age, sex and geographic location to 4–6 controls. All-type dementia was ascertained using the International Classification of Diseases version 10 (ICD-10) diagnosis supplemented with prescribed medicine records. Eight chronic diseases were selected to assess comorbidities. Four types of medicines were categorized as sedative medicines for analysis. Conditional logistic regression with adjustment for education and marital status as well as either the number of comorbidities or sedative medications use was performed using STATA software. Results: Older people with dementia had lower RTAs risk compared to their controls (odds ratio = 0.43, 95{\%} confidence interval (0.32–0.60), p < 0.001). Significant interaction was observed between dementia and the number of comorbidities for RTAs estimation. Conclusions: The significantly lower RTAs risk for older individuals with dementia observed in our study may be due to people with dementia living at home having a lower frequency of outdoor activities; that is, less exposure to traffic. However, this, together with the interaction between dementia and comorbidities as well as sedative medications, should be investigated further.",
keywords = "Dementia, comorbidity, elderly, public health, road traffic accident, sedative medicine",
author = "Petersen, {Jindong Ding} and Siersma, {Volkert Dirk} and {Depont Christensen}, Ren{\'e} and Storsveen, {Maria Munch} and Nielsen, {Connie Thur{\o}e} and Mikkel Vass and Waldorff, {Frans Boch}",
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T1 - Dementia and road traffic accidents among non-institutionalized older people in Denmark

T2 - A Danish register-based nested case-control study

AU - Petersen, Jindong Ding

AU - Siersma, Volkert Dirk

AU - Depont Christensen, René

AU - Storsveen, Maria Munch

AU - Nielsen, Connie Thurøe

AU - Vass, Mikkel

AU - Waldorff, Frans Boch

PY - 2019/3/1

Y1 - 2019/3/1

N2 - Aim: We used register-based data to estimate the effect of all-type dementia on road traffic accidents (RTAs) risk, combined with comorbidities or sedative medicines, among non-institutionalized older people in Denmark. Methods: The source population was all residents in Denmark aged 65 years and older, alive as of January 1, 2008 (n = 853,228). Cases were those who had any type of RTA in 2009–2014. Each case was matched for age, sex and geographic location to 4–6 controls. All-type dementia was ascertained using the International Classification of Diseases version 10 (ICD-10) diagnosis supplemented with prescribed medicine records. Eight chronic diseases were selected to assess comorbidities. Four types of medicines were categorized as sedative medicines for analysis. Conditional logistic regression with adjustment for education and marital status as well as either the number of comorbidities or sedative medications use was performed using STATA software. Results: Older people with dementia had lower RTAs risk compared to their controls (odds ratio = 0.43, 95% confidence interval (0.32–0.60), p < 0.001). Significant interaction was observed between dementia and the number of comorbidities for RTAs estimation. Conclusions: The significantly lower RTAs risk for older individuals with dementia observed in our study may be due to people with dementia living at home having a lower frequency of outdoor activities; that is, less exposure to traffic. However, this, together with the interaction between dementia and comorbidities as well as sedative medications, should be investigated further.

AB - Aim: We used register-based data to estimate the effect of all-type dementia on road traffic accidents (RTAs) risk, combined with comorbidities or sedative medicines, among non-institutionalized older people in Denmark. Methods: The source population was all residents in Denmark aged 65 years and older, alive as of January 1, 2008 (n = 853,228). Cases were those who had any type of RTA in 2009–2014. Each case was matched for age, sex and geographic location to 4–6 controls. All-type dementia was ascertained using the International Classification of Diseases version 10 (ICD-10) diagnosis supplemented with prescribed medicine records. Eight chronic diseases were selected to assess comorbidities. Four types of medicines were categorized as sedative medicines for analysis. Conditional logistic regression with adjustment for education and marital status as well as either the number of comorbidities or sedative medications use was performed using STATA software. Results: Older people with dementia had lower RTAs risk compared to their controls (odds ratio = 0.43, 95% confidence interval (0.32–0.60), p < 0.001). Significant interaction was observed between dementia and the number of comorbidities for RTAs estimation. Conclusions: The significantly lower RTAs risk for older individuals with dementia observed in our study may be due to people with dementia living at home having a lower frequency of outdoor activities; that is, less exposure to traffic. However, this, together with the interaction between dementia and comorbidities as well as sedative medications, should be investigated further.

KW - Dementia

KW - comorbidity

KW - elderly

KW - public health

KW - road traffic accident

KW - sedative medicine

U2 - 10.1177/1403494818782094

DO - 10.1177/1403494818782094

M3 - Journal article

VL - 47

SP - 221

EP - 228

JO - Scandinavian Journal of Public Health

JF - Scandinavian Journal of Public Health

SN - 1403-4948

IS - 2

ER -