Abstract

Immune memory is a defining feature of the acquired immune system, but activation of the innate immune system can also result in enhanced responsiveness to subsequent triggers. This process has been termed ‘trained immunity’, a de facto innate immune memory. Research in the past decade has pointed to the broad benefits of trained immunity for host defence but has also suggested potentially detrimental outcomes in immune-mediated and chronic inflammatory diseases. Here we define ‘trained immunity’ as a biological process and discuss the innate stimuli and the epigenetic and metabolic reprogramming events that shape the induction of trained immunity.

OriginalsprogEngelsk
TidsskriftNature Reviews. Immunology
Vol/bind20
Udgave nummer6
Sider (fra-til)375-388
ISSN1474-1733
DOI
StatusUdgivet - jun. 2020

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