Decreasing trends in methyldibromo glutaronitrile contact allergy - following regulatory intervention

Jeanne D Johansen, Niels Veien, Grete Laurberg, Christian Avnstorp, Knud Kaaber, Klaus E Andersen, Evy Paulsen, Mette Sommerlund, Jens Thormann, Niels H Nielsen, Susanne Vissing, Ove Kristensen, Berit Kristensen, Tove Agner, Torkil Menné

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Udgivelsesdato: 2008-Jun-4
OriginalsprogEngelsk
TidsskriftContact Dermatitis
Vol/bind59
Udgave nummer1
Sider (fra-til)48-51
ISSN0105-1873
DOI
StatusUdgivet - 4. jun. 2008

Fingeraftryk

Hypersensitivity
Petrolatum
Patch Tests
Eczema
Contact Dermatitis
Denmark

Citer dette

Johansen, Jeanne D ; Veien, Niels ; Laurberg, Grete ; Avnstorp, Christian ; Kaaber, Knud ; Andersen, Klaus E ; Paulsen, Evy ; Sommerlund, Mette ; Thormann, Jens ; Nielsen, Niels H ; Vissing, Susanne ; Kristensen, Ove ; Kristensen, Berit ; Agner, Tove ; Menné, Torkil. / Decreasing trends in methyldibromo glutaronitrile contact allergy - following regulatory intervention. I: Contact Dermatitis. 2008 ; Bind 59, Nr. 1. s. 48-51.
@article{a976a0803c3511dda26c000ea68e967b,
title = "Decreasing trends in methyldibromo glutaronitrile contact allergy - following regulatory intervention",
abstract = "Background: The preservative methyldibromo glutaronitrile (MDBGN) has been banned, first from stay-on, and later from rinse-off cosmetics, in the EU countries because of increasing rates of contact allergy. Objectives: To evaluate the frequency of contact allergy to MDBGN among patients patch tested by the Danish Contact Dermatitis Group just before and following regulatory decisions. Patients/Methods: The data set comprised 19 279 consecutive eczema patients patch tested from 2003-2007 with MDBGN 0.3{\%} in petrolatum (pet.) or, in a minority of patients, with Euxyl Ktrade mark 400 1.5{\%} in pet. Results: A significantly decreasing trend in the frequency of positive patch tests to MDBGN was found from 4.6{\%} in 2003 to 2.6{\%} in 2007 (P < 0.001). The decreasing trend was seen for both men and women. A significantly decreasing proportion of cases with a current relevance of contact allergy to MDBGN was also seen from 51.3{\%} in 2003 to 29{\%} in 2007 (P < 0.001). Conclusions: Regulatory interventions have already had a major effect on allergic disease due to MDBGN in Denmark. The same trends are likely to be seen in other EU countries.",
author = "Johansen, {Jeanne D} and Niels Veien and Grete Laurberg and Christian Avnstorp and Knud Kaaber and Andersen, {Klaus E} and Evy Paulsen and Mette Sommerlund and Jens Thormann and Nielsen, {Niels H} and Susanne Vissing and Ove Kristensen and Berit Kristensen and Tove Agner and Torkil Menn{\'e}",
year = "2008",
month = "6",
day = "4",
doi = "10.1111/j.1600-0536.2008.01364.x",
language = "English",
volume = "59",
pages = "48--51",
journal = "Contact Dermatitis",
issn = "0105-1873",
publisher = "Wiley-Blackwell",
number = "1",

}

Johansen, JD, Veien, N, Laurberg, G, Avnstorp, C, Kaaber, K, Andersen, KE, Paulsen, E, Sommerlund, M, Thormann, J, Nielsen, NH, Vissing, S, Kristensen, O, Kristensen, B, Agner, T & Menné, T 2008, 'Decreasing trends in methyldibromo glutaronitrile contact allergy - following regulatory intervention', Contact Dermatitis, bind 59, nr. 1, s. 48-51. https://doi.org/10.1111/j.1600-0536.2008.01364.x

Decreasing trends in methyldibromo glutaronitrile contact allergy - following regulatory intervention. / Johansen, Jeanne D; Veien, Niels; Laurberg, Grete; Avnstorp, Christian; Kaaber, Knud; Andersen, Klaus E; Paulsen, Evy; Sommerlund, Mette; Thormann, Jens; Nielsen, Niels H; Vissing, Susanne; Kristensen, Ove; Kristensen, Berit; Agner, Tove; Menné, Torkil.

I: Contact Dermatitis, Bind 59, Nr. 1, 04.06.2008, s. 48-51.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Decreasing trends in methyldibromo glutaronitrile contact allergy - following regulatory intervention

AU - Johansen, Jeanne D

AU - Veien, Niels

AU - Laurberg, Grete

AU - Avnstorp, Christian

AU - Kaaber, Knud

AU - Andersen, Klaus E

AU - Paulsen, Evy

AU - Sommerlund, Mette

AU - Thormann, Jens

AU - Nielsen, Niels H

AU - Vissing, Susanne

AU - Kristensen, Ove

AU - Kristensen, Berit

AU - Agner, Tove

AU - Menné, Torkil

PY - 2008/6/4

Y1 - 2008/6/4

N2 - Background: The preservative methyldibromo glutaronitrile (MDBGN) has been banned, first from stay-on, and later from rinse-off cosmetics, in the EU countries because of increasing rates of contact allergy. Objectives: To evaluate the frequency of contact allergy to MDBGN among patients patch tested by the Danish Contact Dermatitis Group just before and following regulatory decisions. Patients/Methods: The data set comprised 19 279 consecutive eczema patients patch tested from 2003-2007 with MDBGN 0.3% in petrolatum (pet.) or, in a minority of patients, with Euxyl Ktrade mark 400 1.5% in pet. Results: A significantly decreasing trend in the frequency of positive patch tests to MDBGN was found from 4.6% in 2003 to 2.6% in 2007 (P < 0.001). The decreasing trend was seen for both men and women. A significantly decreasing proportion of cases with a current relevance of contact allergy to MDBGN was also seen from 51.3% in 2003 to 29% in 2007 (P < 0.001). Conclusions: Regulatory interventions have already had a major effect on allergic disease due to MDBGN in Denmark. The same trends are likely to be seen in other EU countries.

AB - Background: The preservative methyldibromo glutaronitrile (MDBGN) has been banned, first from stay-on, and later from rinse-off cosmetics, in the EU countries because of increasing rates of contact allergy. Objectives: To evaluate the frequency of contact allergy to MDBGN among patients patch tested by the Danish Contact Dermatitis Group just before and following regulatory decisions. Patients/Methods: The data set comprised 19 279 consecutive eczema patients patch tested from 2003-2007 with MDBGN 0.3% in petrolatum (pet.) or, in a minority of patients, with Euxyl Ktrade mark 400 1.5% in pet. Results: A significantly decreasing trend in the frequency of positive patch tests to MDBGN was found from 4.6% in 2003 to 2.6% in 2007 (P < 0.001). The decreasing trend was seen for both men and women. A significantly decreasing proportion of cases with a current relevance of contact allergy to MDBGN was also seen from 51.3% in 2003 to 29% in 2007 (P < 0.001). Conclusions: Regulatory interventions have already had a major effect on allergic disease due to MDBGN in Denmark. The same trends are likely to be seen in other EU countries.

U2 - 10.1111/j.1600-0536.2008.01364.x

DO - 10.1111/j.1600-0536.2008.01364.x

M3 - Journal article

VL - 59

SP - 48

EP - 51

JO - Contact Dermatitis

JF - Contact Dermatitis

SN - 0105-1873

IS - 1

ER -