Decorin is down-regulated in multiple myeloma and MGUS bone marrow plasma and inhibits HGF-induced myeloma plasma cell viability and migration

Ida Bruun Kristensen, Lise Mariager Pedersen, Torstein Baade Rø, Jacob Haaber Christensen, Maria Bibi Lyng, Lars Melholt Rasmussen, Henrik J Ditzel, Magne Børset, Niels Abildgaard

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Abstract

OBJECTIVES: Decorin is a stromal-produced small leucine-rich proteoglycan known to attenuate tumour pro-survival, migration, proliferation and angiogenic signalling pathways. Recent studies have shown that decorin interacts with the hepatocyte growth factor (HGF) receptor c-Met, a potential key pathway in multiple myeloma (MM). METHODS: Decorin levels in paired peripheral blood and bone marrow plasma samples from healthy volunteers (HV) (n=23), and patients with monoclonal gammopathy of undetermined significance (MGUS) (n=41) and MM (n=19) were determined by ELISA. Further, the ability of decorin to inhibit HGF-induced effects on MM cell lines were analysed in vitro using cell viability and Transwell migration assays. RESULTS: We found that decorin concentrations were significantly higher (p
OriginalsprogEngelsk
TidsskriftEuropean Journal of Haematology
Vol/bind91
Udgave nummer3
Sider (fra-til)196–200
Antal sider5
ISSN0902-4441
DOI
StatusUdgivet - sep. 2013

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E-pub

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