DBDS Genomic Cohort, a prospective and comprehensive resource for integrative and temporal analysis of genetic, environmental and lifestyle factors affecting health of blood donors

Thomas Folkmann Hansen, Karina Banasik, Christian Erikstrup, Ole Birger Pedersen, David Westergaard, Piotr Chmura, Kaspar Rene Nielsen, Lise W Thørner, Henrik Hjalgrim, Helene M. Paarup, Margit Hørup Larsen, Mikkel Petersen, Poul Jørgen Jennum, Steffen Andersen, Mette Nyegaard, Gregor Borut Ernst Jemec, Jes Olesen, Thomas Werge, Pär Ingemar Johansson, Erik Sørensen & 3 andre Søren Brunak, Henrik Ullum, Kristoffer Sølvsten Burgdorf

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Resumé

Purpose To establish a cohort that enables identification of genomic factors that influence human health and empower increased blood donor health and safe blood transfusions. Human health is complex and involves several factors, a major one being the genomic aspect. The genomic era has resulted in many consortia encompassing large samples sizes, which has proven successful for identifying genetic factors associated with specific traits. However, it remains a big challenge to establish large cohorts that facilitate studies of the interaction between genetic factors, environmental and life-style factors as these change over the course of life. A major obstacle to such endeavours is that it is difficult to revisit participants to retrieve additional information and obtain longitudinal, consecutive measurements. Participants Blood donors (n=110 000) have given consent to participate in the Danish Blood Donor Study. The study uses the infrastructure of the Danish blood banks. Findings to date The cohort comprises extensive phenotype data and whole genome genotyping data. Further, it is possible to retrieve additional phenotype data from national registries as well as from the donors at future visits, including consecutive measurements. Future plans To provide new knowledge on factors influencing our health and thus provide a platform for studying the influence of genomic factors on human health, in particular the interaction between environmental and genetic factors.

OriginalsprogEngelsk
Artikelnummere028401
TidsskriftB M J Open
Vol/bind9
Udgave nummer6
Antal sider7
ISSN2044-6055
DOI
StatusUdgivet - 9. jun. 2019

Fingeraftryk

Health
Sample Size
Registries
Cohort Studies
4,4'-dibenzamido-2,2'-stilbenedisulfonic acid

Citer dette

Hansen, Thomas Folkmann ; Banasik, Karina ; Erikstrup, Christian ; Pedersen, Ole Birger ; Westergaard, David ; Chmura, Piotr ; Nielsen, Kaspar Rene ; Thørner, Lise W ; Hjalgrim, Henrik ; Paarup, Helene M. ; Larsen, Margit Hørup ; Petersen, Mikkel ; Jennum, Poul Jørgen ; Andersen, Steffen ; Nyegaard, Mette ; Jemec, Gregor Borut Ernst ; Olesen, Jes ; Werge, Thomas ; Johansson, Pär Ingemar ; Sørensen, Erik ; Brunak, Søren ; Ullum, Henrik ; Burgdorf, Kristoffer Sølvsten. / DBDS Genomic Cohort, a prospective and comprehensive resource for integrative and temporal analysis of genetic, environmental and lifestyle factors affecting health of blood donors. I: B M J Open. 2019 ; Bind 9, Nr. 6.
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abstract = "Purpose To establish a cohort that enables identification of genomic factors that influence human health and empower increased blood donor health and safe blood transfusions. Human health is complex and involves several factors, a major one being the genomic aspect. The genomic era has resulted in many consortia encompassing large samples sizes, which has proven successful for identifying genetic factors associated with specific traits. However, it remains a big challenge to establish large cohorts that facilitate studies of the interaction between genetic factors, environmental and life-style factors as these change over the course of life. A major obstacle to such endeavours is that it is difficult to revisit participants to retrieve additional information and obtain longitudinal, consecutive measurements. Participants Blood donors (n=110 000) have given consent to participate in the Danish Blood Donor Study. The study uses the infrastructure of the Danish blood banks. Findings to date The cohort comprises extensive phenotype data and whole genome genotyping data. Further, it is possible to retrieve additional phenotype data from national registries as well as from the donors at future visits, including consecutive measurements. Future plans To provide new knowledge on factors influencing our health and thus provide a platform for studying the influence of genomic factors on human health, in particular the interaction between environmental and genetic factors.",
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author = "Hansen, {Thomas Folkmann} and Karina Banasik and Christian Erikstrup and Pedersen, {Ole Birger} and David Westergaard and Piotr Chmura and Nielsen, {Kaspar Rene} and Th{\o}rner, {Lise W} and Henrik Hjalgrim and Paarup, {Helene M.} and Larsen, {Margit H{\o}rup} and Mikkel Petersen and Jennum, {Poul J{\o}rgen} and Steffen Andersen and Mette Nyegaard and Jemec, {Gregor Borut Ernst} and Jes Olesen and Thomas Werge and Johansson, {P{\"a}r Ingemar} and Erik S{\o}rensen and S{\o}ren Brunak and Henrik Ullum and Burgdorf, {Kristoffer S{\o}lvsten}",
year = "2019",
month = "6",
day = "9",
doi = "10.1136/bmjopen-2018-028401",
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Hansen, TF, Banasik, K, Erikstrup, C, Pedersen, OB, Westergaard, D, Chmura, P, Nielsen, KR, Thørner, LW, Hjalgrim, H, Paarup, HM, Larsen, MH, Petersen, M, Jennum, PJ, Andersen, S, Nyegaard, M, Jemec, GBE, Olesen, J, Werge, T, Johansson, PI, Sørensen, E, Brunak, S, Ullum, H & Burgdorf, KS 2019, 'DBDS Genomic Cohort, a prospective and comprehensive resource for integrative and temporal analysis of genetic, environmental and lifestyle factors affecting health of blood donors', B M J Open, bind 9, nr. 6, e028401. https://doi.org/10.1136/bmjopen-2018-028401

DBDS Genomic Cohort, a prospective and comprehensive resource for integrative and temporal analysis of genetic, environmental and lifestyle factors affecting health of blood donors. / Hansen, Thomas Folkmann; Banasik, Karina; Erikstrup, Christian; Pedersen, Ole Birger; Westergaard, David; Chmura, Piotr; Nielsen, Kaspar Rene; Thørner, Lise W; Hjalgrim, Henrik; Paarup, Helene M.; Larsen, Margit Hørup; Petersen, Mikkel; Jennum, Poul Jørgen; Andersen, Steffen; Nyegaard, Mette; Jemec, Gregor Borut Ernst; Olesen, Jes; Werge, Thomas; Johansson, Pär Ingemar; Sørensen, Erik; Brunak, Søren; Ullum, Henrik; Burgdorf, Kristoffer Sølvsten.

I: B M J Open, Bind 9, Nr. 6, e028401, 09.06.2019.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - DBDS Genomic Cohort, a prospective and comprehensive resource for integrative and temporal analysis of genetic, environmental and lifestyle factors affecting health of blood donors

AU - Hansen, Thomas Folkmann

AU - Banasik, Karina

AU - Erikstrup, Christian

AU - Pedersen, Ole Birger

AU - Westergaard, David

AU - Chmura, Piotr

AU - Nielsen, Kaspar Rene

AU - Thørner, Lise W

AU - Hjalgrim, Henrik

AU - Paarup, Helene M.

AU - Larsen, Margit Hørup

AU - Petersen, Mikkel

AU - Jennum, Poul Jørgen

AU - Andersen, Steffen

AU - Nyegaard, Mette

AU - Jemec, Gregor Borut Ernst

AU - Olesen, Jes

AU - Werge, Thomas

AU - Johansson, Pär Ingemar

AU - Sørensen, Erik

AU - Brunak, Søren

AU - Ullum, Henrik

AU - Burgdorf, Kristoffer Sølvsten

PY - 2019/6/9

Y1 - 2019/6/9

N2 - Purpose To establish a cohort that enables identification of genomic factors that influence human health and empower increased blood donor health and safe blood transfusions. Human health is complex and involves several factors, a major one being the genomic aspect. The genomic era has resulted in many consortia encompassing large samples sizes, which has proven successful for identifying genetic factors associated with specific traits. However, it remains a big challenge to establish large cohorts that facilitate studies of the interaction between genetic factors, environmental and life-style factors as these change over the course of life. A major obstacle to such endeavours is that it is difficult to revisit participants to retrieve additional information and obtain longitudinal, consecutive measurements. Participants Blood donors (n=110 000) have given consent to participate in the Danish Blood Donor Study. The study uses the infrastructure of the Danish blood banks. Findings to date The cohort comprises extensive phenotype data and whole genome genotyping data. Further, it is possible to retrieve additional phenotype data from national registries as well as from the donors at future visits, including consecutive measurements. Future plans To provide new knowledge on factors influencing our health and thus provide a platform for studying the influence of genomic factors on human health, in particular the interaction between environmental and genetic factors.

AB - Purpose To establish a cohort that enables identification of genomic factors that influence human health and empower increased blood donor health and safe blood transfusions. Human health is complex and involves several factors, a major one being the genomic aspect. The genomic era has resulted in many consortia encompassing large samples sizes, which has proven successful for identifying genetic factors associated with specific traits. However, it remains a big challenge to establish large cohorts that facilitate studies of the interaction between genetic factors, environmental and life-style factors as these change over the course of life. A major obstacle to such endeavours is that it is difficult to revisit participants to retrieve additional information and obtain longitudinal, consecutive measurements. Participants Blood donors (n=110 000) have given consent to participate in the Danish Blood Donor Study. The study uses the infrastructure of the Danish blood banks. Findings to date The cohort comprises extensive phenotype data and whole genome genotyping data. Further, it is possible to retrieve additional phenotype data from national registries as well as from the donors at future visits, including consecutive measurements. Future plans To provide new knowledge on factors influencing our health and thus provide a platform for studying the influence of genomic factors on human health, in particular the interaction between environmental and genetic factors.

KW - genetics

KW - preventive medicine

KW - public health

U2 - 10.1136/bmjopen-2018-028401

DO - 10.1136/bmjopen-2018-028401

M3 - Journal article

VL - 9

JO - B M J Open

JF - B M J Open

SN - 2044-6055

IS - 6

M1 - e028401

ER -