DAZL binds to the transcripts of several Tssk genes in germ cells

Mei Zeng, Wenqian Deng, Xinying Wang, Weimin Qiu, Yanyan Liu, Huaqin Sun, Dachang Tao, Sizhong Zhang, Yongxin Ma

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Resumé

The Dazl gene encodes a germ-cell-specific RNA-binding protein which is essential for spermatogenesis. It has been proposed that this protein (DAZL) binds to RNA in the cytoplasm of germ cells and controls spermatogenesis. Using the specific nucleic acids associated with proteins (SNAAP) technique, we identified 17 target mRNAs bound by mDAZL. Among these transcripts, we focused on TSSK2, which encodes a testis-specific serine/threonine kinase. To date, five TSSK family members have been cloned, and all are exclusively expressed in the testis. We demonstrated that in addition to the TSSK1 3'UTR , the 3'UTRs of TSSKs 2 and 4 were bound by human and mouse DAZL, and that human DAZL (hDAZL) bound to the 3'UTR of human TSSK5 (hTSSK5). Our results suggest that the Dazl gene may play different roles in human and mouse spermatogenesis by regulating different members of the downstream gene family.
Udgivelsesdato: 2008
OriginalsprogEngelsk
TidsskriftBiochemistry and Molecular Biology Reports
Vol/bind41
Udgave nummer4
Sider (fra-til)300-304
Antal sider4
ISSN1976-6696
StatusUdgivet - 1. jan. 2008

Fingeraftryk

Germ Cells
Genes
Cells

Citer dette

Zeng, M., Deng, W., Wang, X., Qiu, W., Liu, Y., Sun, H., ... Ma, Y. (2008). DAZL binds to the transcripts of several Tssk genes in germ cells. Biochemistry and Molecular Biology Reports, 41(4), 300-304.
Zeng, Mei ; Deng, Wenqian ; Wang, Xinying ; Qiu, Weimin ; Liu, Yanyan ; Sun, Huaqin ; Tao, Dachang ; Zhang, Sizhong ; Ma, Yongxin. / DAZL binds to the transcripts of several Tssk genes in germ cells. I: Biochemistry and Molecular Biology Reports. 2008 ; Bind 41, Nr. 4. s. 300-304.
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title = "DAZL binds to the transcripts of several Tssk genes in germ cells",
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keywords = "Dazl gene, RNA-binding protein, Spermatogenesis, Target mRNAs, TSSK",
author = "Mei Zeng and Wenqian Deng and Xinying Wang and Weimin Qiu and Yanyan Liu and Huaqin Sun and Dachang Tao and Sizhong Zhang and Yongxin Ma",
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Zeng, M, Deng, W, Wang, X, Qiu, W, Liu, Y, Sun, H, Tao, D, Zhang, S & Ma, Y 2008, 'DAZL binds to the transcripts of several Tssk genes in germ cells', Biochemistry and Molecular Biology Reports, bind 41, nr. 4, s. 300-304.

DAZL binds to the transcripts of several Tssk genes in germ cells. / Zeng, Mei; Deng, Wenqian; Wang, Xinying; Qiu, Weimin; Liu, Yanyan; Sun, Huaqin; Tao, Dachang; Zhang, Sizhong; Ma, Yongxin.

I: Biochemistry and Molecular Biology Reports, Bind 41, Nr. 4, 01.01.2008, s. 300-304.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - DAZL binds to the transcripts of several Tssk genes in germ cells

AU - Zeng, Mei

AU - Deng, Wenqian

AU - Wang, Xinying

AU - Qiu, Weimin

AU - Liu, Yanyan

AU - Sun, Huaqin

AU - Tao, Dachang

AU - Zhang, Sizhong

AU - Ma, Yongxin

PY - 2008/1/1

Y1 - 2008/1/1

N2 -  

AB -  

KW - Dazl gene, RNA-binding protein, Spermatogenesis, Target mRNAs, TSSK

M3 - Journal article

VL - 41

SP - 300

EP - 304

JO - B M B Reports

JF - B M B Reports

SN - 1976-6696

IS - 4

ER -

Zeng M, Deng W, Wang X, Qiu W, Liu Y, Sun H et al. DAZL binds to the transcripts of several Tssk genes in germ cells. Biochemistry and Molecular Biology Reports. 2008 jan 1;41(4):300-304.