Data Mining Identifies Digit Symbol Substitution Test Score and Serum Cystatin C as Dominant Predictors of Mortality in Older Men and Women

W. R. Swindell, S. R. Cummings, J. L. Sanders, P. Caserotti, C. Rosano, S. Satterfield, E. S. Strotmeyer, T. B. Harris, E. M. Simonsick, P. M. Cawthon

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Resumé

Background: Characterization of long-term health trajectory in older individuals is important for proactive health management. However, the relative prognostic value of information contained in clinical profiles of nonfrail older adults is often unclear. Methods: We screened 825 phenotypic and genetic measures evaluated during the Health, Aging, and Body Composition Study (Health ABC) baseline visit (3,067 men and women aged 70-79). Variables that best predicted mortality over 13 years of follow-up were identified using 10-fold cross-validation. Results: Mortality was most strongly associated with low Digit Symbol Substitution Test (DSST) score (DSST = 1.30 mg/mL; 12.1% of cohort; HR = 2.25 +/- 0.07). These variables predicted mortality better than 823 other measures, including baseline age and a 45-variable health deficit index. Given elevated cystatin C (>= 1.30 mg/mL), mortality risk was further increased by high serum creatinine, high abdominal visceral fat density, and smoking history (2.52
OriginalsprogEngelsk
TidsskriftRejuvenation Research
Vol/bind15
Udgave nummer4
Sider (fra-til)405-413
Antal sider9
ISSN1549-1684
DOI
StatusUdgivet - 2012

Citer dette

Swindell, W. R. ; Cummings, S. R. ; Sanders, J. L. ; Caserotti, P. ; Rosano, C. ; Satterfield, S. ; Strotmeyer, E. S. ; Harris, T. B. ; Simonsick, E. M. ; Cawthon, P. M. / Data Mining Identifies Digit Symbol Substitution Test Score and Serum Cystatin C as Dominant Predictors of Mortality in Older Men and Women. I: Rejuvenation Research. 2012 ; Bind 15, Nr. 4. s. 405-413.
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title = "Data Mining Identifies Digit Symbol Substitution Test Score and Serum Cystatin C as Dominant Predictors of Mortality in Older Men and Women",
abstract = "Background: Characterization of long-term health trajectory in older individuals is important for proactive health management. However, the relative prognostic value of information contained in clinical profiles of nonfrail older adults is often unclear. Methods: We screened 825 phenotypic and genetic measures evaluated during the Health, Aging, and Body Composition Study (Health ABC) baseline visit (3,067 men and women aged 70-79). Variables that best predicted mortality over 13 years of follow-up were identified using 10-fold cross-validation. Results: Mortality was most strongly associated with low Digit Symbol Substitution Test (DSST) score (DSST = 1.30 mg/mL; 12.1{\%} of cohort; HR = 2.25 +/- 0.07). These variables predicted mortality better than 823 other measures, including baseline age and a 45-variable health deficit index. Given elevated cystatin C (>= 1.30 mg/mL), mortality risk was further increased by high serum creatinine, high abdominal visceral fat density, and smoking history (2.52",
author = "Swindell, {W. R.} and Cummings, {S. R.} and Sanders, {J. L.} and P. Caserotti and C. Rosano and S. Satterfield and Strotmeyer, {E. S.} and Harris, {T. B.} and Simonsick, {E. M.} and Cawthon, {P. M.}",
year = "2012",
doi = "10.1089/rej.2011.1297",
language = "English",
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journal = "Rejuvenation Research",
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Swindell, WR, Cummings, SR, Sanders, JL, Caserotti, P, Rosano, C, Satterfield, S, Strotmeyer, ES, Harris, TB, Simonsick, EM & Cawthon, PM 2012, 'Data Mining Identifies Digit Symbol Substitution Test Score and Serum Cystatin C as Dominant Predictors of Mortality in Older Men and Women', Rejuvenation Research, bind 15, nr. 4, s. 405-413. https://doi.org/10.1089/rej.2011.1297

Data Mining Identifies Digit Symbol Substitution Test Score and Serum Cystatin C as Dominant Predictors of Mortality in Older Men and Women. / Swindell, W. R.; Cummings, S. R.; Sanders, J. L.; Caserotti, P.; Rosano, C.; Satterfield, S.; Strotmeyer, E. S.; Harris, T. B.; Simonsick, E. M.; Cawthon, P. M.

I: Rejuvenation Research, Bind 15, Nr. 4, 2012, s. 405-413.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Data Mining Identifies Digit Symbol Substitution Test Score and Serum Cystatin C as Dominant Predictors of Mortality in Older Men and Women

AU - Swindell, W. R.

AU - Cummings, S. R.

AU - Sanders, J. L.

AU - Caserotti, P.

AU - Rosano, C.

AU - Satterfield, S.

AU - Strotmeyer, E. S.

AU - Harris, T. B.

AU - Simonsick, E. M.

AU - Cawthon, P. M.

PY - 2012

Y1 - 2012

N2 - Background: Characterization of long-term health trajectory in older individuals is important for proactive health management. However, the relative prognostic value of information contained in clinical profiles of nonfrail older adults is often unclear. Methods: We screened 825 phenotypic and genetic measures evaluated during the Health, Aging, and Body Composition Study (Health ABC) baseline visit (3,067 men and women aged 70-79). Variables that best predicted mortality over 13 years of follow-up were identified using 10-fold cross-validation. Results: Mortality was most strongly associated with low Digit Symbol Substitution Test (DSST) score (DSST = 1.30 mg/mL; 12.1% of cohort; HR = 2.25 +/- 0.07). These variables predicted mortality better than 823 other measures, including baseline age and a 45-variable health deficit index. Given elevated cystatin C (>= 1.30 mg/mL), mortality risk was further increased by high serum creatinine, high abdominal visceral fat density, and smoking history (2.52

AB - Background: Characterization of long-term health trajectory in older individuals is important for proactive health management. However, the relative prognostic value of information contained in clinical profiles of nonfrail older adults is often unclear. Methods: We screened 825 phenotypic and genetic measures evaluated during the Health, Aging, and Body Composition Study (Health ABC) baseline visit (3,067 men and women aged 70-79). Variables that best predicted mortality over 13 years of follow-up were identified using 10-fold cross-validation. Results: Mortality was most strongly associated with low Digit Symbol Substitution Test (DSST) score (DSST = 1.30 mg/mL; 12.1% of cohort; HR = 2.25 +/- 0.07). These variables predicted mortality better than 823 other measures, including baseline age and a 45-variable health deficit index. Given elevated cystatin C (>= 1.30 mg/mL), mortality risk was further increased by high serum creatinine, high abdominal visceral fat density, and smoking history (2.52

U2 - 10.1089/rej.2011.1297

DO - 10.1089/rej.2011.1297

M3 - Journal article

VL - 15

SP - 405

EP - 413

JO - Rejuvenation Research

JF - Rejuvenation Research

SN - 1549-1684

IS - 4

ER -