D-galactose-induced brain ageing model: A systematic review and meta-analysis on cognitive outcomes and oxidative stress indices

Saeed Sadigh-Eteghad, Alireza Majdi*, Sarah K. McCann, Javad Mahmoudi, Manouchehr S. Vafaee, Malcolm R. Macleod

*Kontaktforfatter for dette arbejde

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Abstrakt

Animal models are commonly used in brain ageing research. Amongst these, models where rodents are exposed to d-galactose are held to recapitulate a number of features of ageing including neurobehavioral and neurochemical changes. However, results from animal studies are often inconsistent. To better understand the characteristics of the model and effects of d-galactose on neurobehavioral and neurochemical outcomes in rodents we performed a systematic review and meta-analysis. We applied random-effects meta-analysis to evaluate the effect of study features. Our results give an overview of the characteristics of the d-galactose rodent ageing model, including neurobehavioral and neurochemical outcomes. We found that few studies took measures to reduce risks of bias, and substantial heterogeneity in the reported effects of d-galactose in included studies. This highlights the need for improvements in the use of the d-galactose rodent ageing model if it is to provide useful in the development of drugs to treat human ageing.

OriginalsprogEngelsk
Artikelnummere0184122
TidsskriftPLOS ONE
Vol/bind12
Udgave nummer8
Antal sider13
ISSN1932-6203
DOI
StatusUdgivet - 1. aug. 2017
Udgivet eksterntJa

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