Cytokine responses in relation to age, gender, body mass index, Mycobacterium tuberculosis infection, and otitis media among inuit in greenland: Cytokine responses among Inuit in Greenland

Bidragets oversatte titel: Cytokine respons i relation til alder, køn, body mass index, Mycobakterie tuberkulose infektion og otitis media i Grønland: Cytokin respons hos Inuit i Grønland

Nina Odgaard Nielsen, Bolette Soborg, Malene Børresen, Mikael Andersson, Anders Koch

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Objectives: To evaluate the general cytokine responsiveness in Inuit in Greenland and examine the association between stimulated cytokine responses, chronic infections (Mycobacterium tuberculosis infection (MTI) and chronic otitis media (COM)) and BMI.
Methods: A cross sectional health assessment was conducted among inhabitants of Maniitsoq, West Greenland, in 2009 and several health outcomes measured. The prevalence of MTI, overweight and obesity was assessed among 385 school children and 243 adults, and COM was assessed among the children. Cytokine responses were measured in whole blood from a subsample of participants (263 children and 137 adults) after stimulation with phytohaemagluttinin (PHA) or purified protein derivative (PPD). Associations between cytokine concentrations, chronic infections and BMI were estimated by linear regression.
Results: The prevalence of MTI, COM, overweight and obesity was high among study participants. Children with MTI had 2.7 times higher IL-10 concentrations than those without (P=0.01), and girls had 80 % higher IL-10 than boys (P<0.01) after PHA stimulation. IFNγ and TNF concentrations were strongly elevated among children (PIFNγ<0.001 and PTNF<0.001) and adults (PIFNγ<0.001 and PTNF<0.01) with MTI compared to those without after PPD stimulation. Adult women had significantly lower IFNγ (P=0.03) and TNF (P=0.04) concentrations than men. TNF was positively correlated with BMI in children (P=0.01), and IL-10 was positively correlated with BMI in adults (P=0.0004) after PPD stimulation.
Conclusion: We found cytokine patterns similar to those reported from other immune competent study populations. The study does therefore not support the suggestion that Inuit may have impaired immune reactivity to infection.
OriginalsprogEngelsk
TidsskriftAmerican Journal of Human Biology
Vol/bind25
Udgave nummer1
Sider (fra-til)20-8
Antal sider9
ISSN1042-0533
DOI
StatusUdgivet - 2013

Fingeraftryk

Greenland
otitis media
tuberculosis
Otitis Media
Mycobacterium tuberculosis
body mass
contagious disease
body mass index
gender
Body Mass Index
cytokines
infection
index

Emneord

  • Cytokine responses
  • Inuit, chronic infection
  • BMI
  • overweight
  • obesity
  • whole blood culture
  • Greenland

Citer dette

@article{ff804c89eb2241f0bc53f07a26f2c612,
title = "Cytokine responses in relation to age, gender, body mass index, Mycobacterium tuberculosis infection, and otitis media among inuit in greenland: Cytokine responses among Inuit in Greenland",
abstract = "To evaluate the cytokine response pattern in Inuit in Greenland in relation to age, gender, body mass index (BMI), Mycobacterium tuberculosis infection (MTI), and otitis media (OM) to assess whether Inuit may have signs of impaired immune responsiveness to infection.",
keywords = "Cytokine responses, Inuit, chronic infection, BMI, overweight, obesity, whole blood culture, Greenland",
author = "Nielsen, {Nina Odgaard} and Bolette Soborg and Malene B{\o}rresen and Mikael Andersson and Anders Koch",
note = "Copyright {\circledC} 2012 Wiley Periodicals, Inc.",
year = "2013",
doi = "10.1002/ajhb.22332",
language = "English",
volume = "25",
pages = "20--8",
journal = "American Journal of Human Biology",
issn = "1042-0533",
publisher = "John Wiley & Sons Ltd",
number = "1",

}

Cytokine responses in relation to age, gender, body mass index, Mycobacterium tuberculosis infection, and otitis media among inuit in greenland : Cytokine responses among Inuit in Greenland. / Nielsen, Nina Odgaard; Soborg, Bolette; Børresen, Malene; Andersson, Mikael; Koch, Anders.

I: American Journal of Human Biology, Bind 25, Nr. 1, 2013, s. 20-8.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Cytokine responses in relation to age, gender, body mass index, Mycobacterium tuberculosis infection, and otitis media among inuit in greenland

T2 - Cytokine responses among Inuit in Greenland

AU - Nielsen, Nina Odgaard

AU - Soborg, Bolette

AU - Børresen, Malene

AU - Andersson, Mikael

AU - Koch, Anders

N1 - Copyright © 2012 Wiley Periodicals, Inc.

PY - 2013

Y1 - 2013

N2 - To evaluate the cytokine response pattern in Inuit in Greenland in relation to age, gender, body mass index (BMI), Mycobacterium tuberculosis infection (MTI), and otitis media (OM) to assess whether Inuit may have signs of impaired immune responsiveness to infection.

AB - To evaluate the cytokine response pattern in Inuit in Greenland in relation to age, gender, body mass index (BMI), Mycobacterium tuberculosis infection (MTI), and otitis media (OM) to assess whether Inuit may have signs of impaired immune responsiveness to infection.

KW - Cytokine responses

KW - Inuit, chronic infection

KW - BMI

KW - overweight

KW - obesity

KW - whole blood culture

KW - Greenland

U2 - 10.1002/ajhb.22332

DO - 10.1002/ajhb.22332

M3 - Journal article

C2 - 23073911

VL - 25

SP - 20

EP - 28

JO - American Journal of Human Biology

JF - American Journal of Human Biology

SN - 1042-0533

IS - 1

ER -