Cytogenetic findings in adult secondary acute myeloid leukemia (AML): frequency of favorable and adverse chromosomal aberrations do not differ from adult de novo AML

Birgitte S Preiss, Olav J Bergman, Lone S Friis, Anne Sørensen, Michael Frederiksen, Ole V Gadeberg, Torben Mourits-Andersen, Birthe Østergaard, Gitte B Kerndrup, AML Study Group of Southern Denmark

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

During a 15-year period, 161 adult patients were diagnosed with secondary acute myeloid leukemia (s-AML) in the region of Southern Denmark. In 73 patients, the AML diagnosis was preceded by myelodysplastic syndrome (MDS-AML), in 31 patients by an antecedent hematologic disease, and in 57 patients by treatment with chemotherapy and/or irradiation (t-AML). Cytogenetic analysis was carried out in 93%, of which 61% had clonal chromosome aberrations. MDS-AML correlated to a normal karyotype (P <0.001). t-AML correlated to abnormal clones with numerical and structural aberrations (P = 0.03), five or more unrelated aberrations (P = 0.03), marker chromosomes (P = 0.006), abnormal mitoses only (P = 0.01), female sex (P <0.001), and -7 (P = 0.006). Centromeric breakage correlated to a complex karyotype (P = 0.01). The frequencies of aberrations in s-AML patients were compared with an age-matched group of de novo AML patients diagnosed in the same area and period. In this comparison, s-AML only correlated to -7 (P = 0.02). In 42 patients, we found that MDS patients with an abnormal karyotype were more likely to show cytogenetic evolution during progression to AML than MDS patients with a normal karyotype (P = 0.01). We conclude that population-based cytogenetic studies of adult s-AML and age- and sex-matched de novo AML show comparable distributions of chromosome abnormalities.
OriginalsprogEngelsk
TidsskriftCancer Genetics and Cytogenetics
Vol/bind202
Udgave nummer2
Sider (fra-til)108-22
Antal sider15
ISSN0165-4608
DOI
StatusUdgivet - 15. okt. 2010

Fingeraftryk

Acute Myeloid Leukemia
Cytogenetics
Hematologic Diseases
Denmark
Genetic Markers
Research Design
Clone Cells
Age Groups

Citer dette

Preiss, Birgitte S ; Bergman, Olav J ; Friis, Lone S ; Sørensen, Anne ; Frederiksen, Michael ; Gadeberg, Ole V ; Mourits-Andersen, Torben ; Østergaard, Birthe ; Kerndrup, Gitte B ; AML Study Group of Southern Denmark. / Cytogenetic findings in adult secondary acute myeloid leukemia (AML): frequency of favorable and adverse chromosomal aberrations do not differ from adult de novo AML. I: Cancer Genetics and Cytogenetics. 2010 ; Bind 202, Nr. 2. s. 108-22.
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title = "Cytogenetic findings in adult secondary acute myeloid leukemia (AML): frequency of favorable and adverse chromosomal aberrations do not differ from adult de novo AML",
abstract = "During a 15-year period, 161 adult patients were diagnosed with secondary acute myeloid leukemia (s-AML) in the region of Southern Denmark. In 73 patients, the AML diagnosis was preceded by myelodysplastic syndrome (MDS-AML), in 31 patients by an antecedent hematologic disease, and in 57 patients by treatment with chemotherapy and/or irradiation (t-AML). Cytogenetic analysis was carried out in 93{\%}, of which 61{\%} had clonal chromosome aberrations. MDS-AML correlated to a normal karyotype (P <0.001). t-AML correlated to abnormal clones with numerical and structural aberrations (P = 0.03), five or more unrelated aberrations (P = 0.03), marker chromosomes (P = 0.006), abnormal mitoses only (P = 0.01), female sex (P <0.001), and -7 (P = 0.006). Centromeric breakage correlated to a complex karyotype (P = 0.01). The frequencies of aberrations in s-AML patients were compared with an age-matched group of de novo AML patients diagnosed in the same area and period. In this comparison, s-AML only correlated to -7 (P = 0.02). In 42 patients, we found that MDS patients with an abnormal karyotype were more likely to show cytogenetic evolution during progression to AML than MDS patients with a normal karyotype (P = 0.01). We conclude that population-based cytogenetic studies of adult s-AML and age- and sex-matched de novo AML show comparable distributions of chromosome abnormalities.",
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author = "Preiss, {Birgitte S} and Bergman, {Olav J} and Friis, {Lone S} and Anne S{\o}rensen and Michael Frederiksen and Gadeberg, {Ole V} and Torben Mourits-Andersen and Birthe {\O}stergaard and Kerndrup, {Gitte B} and {AML Study Group of Southern Denmark}",
note = "Copyright {\circledC} 2010 Elsevier Inc. All rights reserved.",
year = "2010",
month = "10",
day = "15",
doi = "10.1016/j.cancergencyto.2010.06.013",
language = "English",
volume = "202",
pages = "108--22",
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Preiss, BS, Bergman, OJ, Friis, LS, Sørensen, A, Frederiksen, M, Gadeberg, OV, Mourits-Andersen, T, Østergaard, B, Kerndrup, GB & AML Study Group of Southern Denmark 2010, 'Cytogenetic findings in adult secondary acute myeloid leukemia (AML): frequency of favorable and adverse chromosomal aberrations do not differ from adult de novo AML', Cancer Genetics and Cytogenetics, bind 202, nr. 2, s. 108-22. https://doi.org/10.1016/j.cancergencyto.2010.06.013

Cytogenetic findings in adult secondary acute myeloid leukemia (AML): frequency of favorable and adverse chromosomal aberrations do not differ from adult de novo AML. / Preiss, Birgitte S; Bergman, Olav J; Friis, Lone S; Sørensen, Anne; Frederiksen, Michael; Gadeberg, Ole V; Mourits-Andersen, Torben; Østergaard, Birthe; Kerndrup, Gitte B; AML Study Group of Southern Denmark.

I: Cancer Genetics and Cytogenetics, Bind 202, Nr. 2, 15.10.2010, s. 108-22.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Cytogenetic findings in adult secondary acute myeloid leukemia (AML): frequency of favorable and adverse chromosomal aberrations do not differ from adult de novo AML

AU - Preiss, Birgitte S

AU - Bergman, Olav J

AU - Friis, Lone S

AU - Sørensen, Anne

AU - Frederiksen, Michael

AU - Gadeberg, Ole V

AU - Mourits-Andersen, Torben

AU - Østergaard, Birthe

AU - Kerndrup, Gitte B

AU - AML Study Group of Southern Denmark

N1 - Copyright © 2010 Elsevier Inc. All rights reserved.

PY - 2010/10/15

Y1 - 2010/10/15

N2 - During a 15-year period, 161 adult patients were diagnosed with secondary acute myeloid leukemia (s-AML) in the region of Southern Denmark. In 73 patients, the AML diagnosis was preceded by myelodysplastic syndrome (MDS-AML), in 31 patients by an antecedent hematologic disease, and in 57 patients by treatment with chemotherapy and/or irradiation (t-AML). Cytogenetic analysis was carried out in 93%, of which 61% had clonal chromosome aberrations. MDS-AML correlated to a normal karyotype (P <0.001). t-AML correlated to abnormal clones with numerical and structural aberrations (P = 0.03), five or more unrelated aberrations (P = 0.03), marker chromosomes (P = 0.006), abnormal mitoses only (P = 0.01), female sex (P <0.001), and -7 (P = 0.006). Centromeric breakage correlated to a complex karyotype (P = 0.01). The frequencies of aberrations in s-AML patients were compared with an age-matched group of de novo AML patients diagnosed in the same area and period. In this comparison, s-AML only correlated to -7 (P = 0.02). In 42 patients, we found that MDS patients with an abnormal karyotype were more likely to show cytogenetic evolution during progression to AML than MDS patients with a normal karyotype (P = 0.01). We conclude that population-based cytogenetic studies of adult s-AML and age- and sex-matched de novo AML show comparable distributions of chromosome abnormalities.

AB - During a 15-year period, 161 adult patients were diagnosed with secondary acute myeloid leukemia (s-AML) in the region of Southern Denmark. In 73 patients, the AML diagnosis was preceded by myelodysplastic syndrome (MDS-AML), in 31 patients by an antecedent hematologic disease, and in 57 patients by treatment with chemotherapy and/or irradiation (t-AML). Cytogenetic analysis was carried out in 93%, of which 61% had clonal chromosome aberrations. MDS-AML correlated to a normal karyotype (P <0.001). t-AML correlated to abnormal clones with numerical and structural aberrations (P = 0.03), five or more unrelated aberrations (P = 0.03), marker chromosomes (P = 0.006), abnormal mitoses only (P = 0.01), female sex (P <0.001), and -7 (P = 0.006). Centromeric breakage correlated to a complex karyotype (P = 0.01). The frequencies of aberrations in s-AML patients were compared with an age-matched group of de novo AML patients diagnosed in the same area and period. In this comparison, s-AML only correlated to -7 (P = 0.02). In 42 patients, we found that MDS patients with an abnormal karyotype were more likely to show cytogenetic evolution during progression to AML than MDS patients with a normal karyotype (P = 0.01). We conclude that population-based cytogenetic studies of adult s-AML and age- and sex-matched de novo AML show comparable distributions of chromosome abnormalities.

KW - Adolescent

KW - Adult

KW - Age Distribution

KW - Aged

KW - Aged, 80 and over

KW - Chromosome Aberrations

KW - Chromosome Breakage

KW - Chromosomes, Human

KW - Cytogenetic Analysis

KW - Denmark

KW - Humans

KW - Incidence

KW - Karyotyping

KW - Leukemia, Myeloid, Acute

KW - Middle Aged

KW - Neoplasm Recurrence, Local

KW - Neoplasms, Second Primary

KW - Ploidies

KW - Young Adult

U2 - 10.1016/j.cancergencyto.2010.06.013

DO - 10.1016/j.cancergencyto.2010.06.013

M3 - Journal article

C2 - 20875873

VL - 202

SP - 108

EP - 122

JO - Cancer genetics and cytogenetics

JF - Cancer genetics and cytogenetics

SN - 0165-4608

IS - 2

ER -