Cytogenetic evaluation of 20 primary breast carcinomas

L R Cavalli, L M Cavaliéri, L A Ribeiro, I J Cavalli, R Silveira, S R Rogatto

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Chromosome analysis was performed on samples from 20 Brazilian patients with breast cancer. All the samples were from untreated patients who presented the clinical symptoms for months or years before surgical intervention. Six cases showed axillary lymph node metastases. Clonal chromosome abnormalities were detected in all cases. The numerical alterations most frequently observed involved the loss of chromosomes X, 19, 20, and 22 followed by gain of chromosomes 9 and 8. Among the structural anomalies observed, there was preferential involvement of chromosomes 11, 6, 1, 7, 3, and 12, supporting previous reports that these chromosomes may harbour genes of importance in the development of breast tumors. Two cases with a family history of breast cancer had in common total or partial trisomy 1.

OriginalsprogEngelsk
TidsskriftHereditas
Vol/bind126
Udgave nummer3
Sider (fra-til)261-268
ISSN0018-0661
DOI
StatusUdgivet - 1997
Udgivet eksterntJa

Fingeraftryk

Cytogenetics
Chromosomes, Human, Pair 19
Chromosomes, Human, Pair 8
Chromosomes, Human, Pair 11
Chromosomes, Human, Pair 6
Trisomy
Lymph Nodes

Citer dette

Cavalli, L. R., Cavaliéri, L. M., Ribeiro, L. A., Cavalli, I. J., Silveira, R., & Rogatto, S. R. (1997). Cytogenetic evaluation of 20 primary breast carcinomas. Hereditas, 126(3), 261-268. https://doi.org/10.1111/j.1601-5223.1997.00261.x
Cavalli, L R ; Cavaliéri, L M ; Ribeiro, L A ; Cavalli, I J ; Silveira, R ; Rogatto, S R. / Cytogenetic evaluation of 20 primary breast carcinomas. I: Hereditas. 1997 ; Bind 126, Nr. 3. s. 261-268.
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Cavalli, LR, Cavaliéri, LM, Ribeiro, LA, Cavalli, IJ, Silveira, R & Rogatto, SR 1997, 'Cytogenetic evaluation of 20 primary breast carcinomas', Hereditas, bind 126, nr. 3, s. 261-268. https://doi.org/10.1111/j.1601-5223.1997.00261.x

Cytogenetic evaluation of 20 primary breast carcinomas. / Cavalli, L R; Cavaliéri, L M; Ribeiro, L A; Cavalli, I J; Silveira, R; Rogatto, S R.

I: Hereditas, Bind 126, Nr. 3, 1997, s. 261-268.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Cytogenetic evaluation of 20 primary breast carcinomas

AU - Cavalli, L R

AU - Cavaliéri, L M

AU - Ribeiro, L A

AU - Cavalli, I J

AU - Silveira, R

AU - Rogatto, S R

PY - 1997

Y1 - 1997

N2 - Chromosome analysis was performed on samples from 20 Brazilian patients with breast cancer. All the samples were from untreated patients who presented the clinical symptoms for months or years before surgical intervention. Six cases showed axillary lymph node metastases. Clonal chromosome abnormalities were detected in all cases. The numerical alterations most frequently observed involved the loss of chromosomes X, 19, 20, and 22 followed by gain of chromosomes 9 and 8. Among the structural anomalies observed, there was preferential involvement of chromosomes 11, 6, 1, 7, 3, and 12, supporting previous reports that these chromosomes may harbour genes of importance in the development of breast tumors. Two cases with a family history of breast cancer had in common total or partial trisomy 1.

AB - Chromosome analysis was performed on samples from 20 Brazilian patients with breast cancer. All the samples were from untreated patients who presented the clinical symptoms for months or years before surgical intervention. Six cases showed axillary lymph node metastases. Clonal chromosome abnormalities were detected in all cases. The numerical alterations most frequently observed involved the loss of chromosomes X, 19, 20, and 22 followed by gain of chromosomes 9 and 8. Among the structural anomalies observed, there was preferential involvement of chromosomes 11, 6, 1, 7, 3, and 12, supporting previous reports that these chromosomes may harbour genes of importance in the development of breast tumors. Two cases with a family history of breast cancer had in common total or partial trisomy 1.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Brazil

KW - Breast Neoplasms

KW - Breast Neoplasms, Male

KW - Carcinoma, Ductal, Breast

KW - Chromosome Aberrations

KW - Chromosome Disorders

KW - Chromosome Mapping

KW - Chromosomes, Human

KW - Female

KW - Humans

KW - Karyotyping

KW - Lymphatic Metastasis

KW - Male

KW - Middle Aged

KW - Neoplasms

KW - Trisomy

KW - X Chromosome

U2 - 10.1111/j.1601-5223.1997.00261.x

DO - 10.1111/j.1601-5223.1997.00261.x

M3 - Journal article

VL - 126

SP - 261

EP - 268

JO - Hereditas

JF - Hereditas

SN - 0018-0661

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ER -

Cavalli LR, Cavaliéri LM, Ribeiro LA, Cavalli IJ, Silveira R, Rogatto SR. Cytogenetic evaluation of 20 primary breast carcinomas. Hereditas. 1997;126(3):261-268. https://doi.org/10.1111/j.1601-5223.1997.00261.x