Cytogenetic comparisons of synchronous carcinomas and polyps in patients with colorectal cancer

G Bardi, L A Parada, L Bomme, N Pandis, R Willén, B Johansson, B Jeppsson, K Beroukas, S Heim, F Mitelman

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Udgivelsesdato: 1997-null
OriginalsprogEngelsk
TidsskriftBritish Journal of Cancer
Vol/bind76
Udgave nummer6
Sider (fra-til)765-9
Antal sider4
ISSN0007-0920
StatusUdgivet - 1. jan. 1997

Fingeraftryk

Cytogenetics
Colorectal Neoplasms
Adenoma
Mucous Membrane
Lymph Nodes
Neoplasms

Citer dette

Bardi, G., Parada, L. A., Bomme, L., Pandis, N., Willén, R., Johansson, B., ... Mitelman, F. (1997). Cytogenetic comparisons of synchronous carcinomas and polyps in patients with colorectal cancer. British Journal of Cancer, 76(6), 765-9.
Bardi, G ; Parada, L A ; Bomme, L ; Pandis, N ; Willén, R ; Johansson, B ; Jeppsson, B ; Beroukas, K ; Heim, S ; Mitelman, F. / Cytogenetic comparisons of synchronous carcinomas and polyps in patients with colorectal cancer. I: British Journal of Cancer. 1997 ; Bind 76, Nr. 6. s. 765-9.
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title = "Cytogenetic comparisons of synchronous carcinomas and polyps in patients with colorectal cancer",
abstract = "Thirty tumorous lesions from seven patients with colorectal cancer were short-term cultured and cytogenetically analysed: 16 non-adenomatous polyps, six adenomas, seven carcinomas, including one in polyp, and one lymph node metastasis. Clonal chromosome aberrations were found in 20 samples in 100{\%} of the carcinomas, in 100{\%} of the adenomas and in 37.5{\%} of the non-adenomatous polyps, i.e. all ten lesions with a normal karyotype were histologically diagnosed as hyperplastic polyps. Although adenomas and carcinomas shared several karyotypic features, two chromosome aberrations, der(8;17)(q10;q10) and -14, were found in carcinomas but not in adenomas, indicating that they might be specifically associated with carcinoma development in the large bowel mucosa. The karyotypic similarity seen between the malignant and benign tumours in the same patient, and also sometimes among non-malignant polyps in the same case, indicates that these microscopically distinct lesions may be part of a single neoplastic clonal expansion.",
keywords = "Adenoma, Adult, Aged, Carcinoma, Chromosome Aberrations, Chromosome Banding, Chromosome Disorders, Clone Cells, Colorectal Neoplasms, Female, Humans, Intestinal Polyps, Karyotyping, Lymphatic Metastasis, Male, Middle Aged",
author = "G Bardi and Parada, {L A} and L Bomme and N Pandis and R Will{\'e}n and B Johansson and B Jeppsson and K Beroukas and S Heim and F Mitelman",
year = "1997",
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language = "English",
volume = "76",
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Bardi, G, Parada, LA, Bomme, L, Pandis, N, Willén, R, Johansson, B, Jeppsson, B, Beroukas, K, Heim, S & Mitelman, F 1997, 'Cytogenetic comparisons of synchronous carcinomas and polyps in patients with colorectal cancer', British Journal of Cancer, bind 76, nr. 6, s. 765-9.

Cytogenetic comparisons of synchronous carcinomas and polyps in patients with colorectal cancer. / Bardi, G; Parada, L A; Bomme, L; Pandis, N; Willén, R; Johansson, B; Jeppsson, B; Beroukas, K; Heim, S; Mitelman, F.

I: British Journal of Cancer, Bind 76, Nr. 6, 01.01.1997, s. 765-9.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Cytogenetic comparisons of synchronous carcinomas and polyps in patients with colorectal cancer

AU - Bardi, G

AU - Parada, L A

AU - Bomme, L

AU - Pandis, N

AU - Willén, R

AU - Johansson, B

AU - Jeppsson, B

AU - Beroukas, K

AU - Heim, S

AU - Mitelman, F

PY - 1997/1/1

Y1 - 1997/1/1

N2 - Thirty tumorous lesions from seven patients with colorectal cancer were short-term cultured and cytogenetically analysed: 16 non-adenomatous polyps, six adenomas, seven carcinomas, including one in polyp, and one lymph node metastasis. Clonal chromosome aberrations were found in 20 samples in 100% of the carcinomas, in 100% of the adenomas and in 37.5% of the non-adenomatous polyps, i.e. all ten lesions with a normal karyotype were histologically diagnosed as hyperplastic polyps. Although adenomas and carcinomas shared several karyotypic features, two chromosome aberrations, der(8;17)(q10;q10) and -14, were found in carcinomas but not in adenomas, indicating that they might be specifically associated with carcinoma development in the large bowel mucosa. The karyotypic similarity seen between the malignant and benign tumours in the same patient, and also sometimes among non-malignant polyps in the same case, indicates that these microscopically distinct lesions may be part of a single neoplastic clonal expansion.

AB - Thirty tumorous lesions from seven patients with colorectal cancer were short-term cultured and cytogenetically analysed: 16 non-adenomatous polyps, six adenomas, seven carcinomas, including one in polyp, and one lymph node metastasis. Clonal chromosome aberrations were found in 20 samples in 100% of the carcinomas, in 100% of the adenomas and in 37.5% of the non-adenomatous polyps, i.e. all ten lesions with a normal karyotype were histologically diagnosed as hyperplastic polyps. Although adenomas and carcinomas shared several karyotypic features, two chromosome aberrations, der(8;17)(q10;q10) and -14, were found in carcinomas but not in adenomas, indicating that they might be specifically associated with carcinoma development in the large bowel mucosa. The karyotypic similarity seen between the malignant and benign tumours in the same patient, and also sometimes among non-malignant polyps in the same case, indicates that these microscopically distinct lesions may be part of a single neoplastic clonal expansion.

KW - Adenoma

KW - Adult

KW - Aged

KW - Carcinoma

KW - Chromosome Aberrations

KW - Chromosome Banding

KW - Chromosome Disorders

KW - Clone Cells

KW - Colorectal Neoplasms

KW - Female

KW - Humans

KW - Intestinal Polyps

KW - Karyotyping

KW - Lymphatic Metastasis

KW - Male

KW - Middle Aged

M3 - Journal article

C2 - 9310243

VL - 76

SP - 765

EP - 769

JO - B J C

JF - B J C

SN - 0007-0920

IS - 6

ER -

Bardi G, Parada LA, Bomme L, Pandis N, Willén R, Johansson B et al. Cytogenetic comparisons of synchronous carcinomas and polyps in patients with colorectal cancer. British Journal of Cancer. 1997 jan 1;76(6):765-9.