Current state of evidence for endolymphatic sac surgery in Menière’s disease: a systematic review

Louise Devantier*, Jesper Hvass Schmidt, Bjarki Ditlev Djurhuus, Dan Dupont Hougaard, Mina Nicole Händel, Frank Liviu-Adelin Guldfred, Henriette Edemann-Callesen


Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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Background: Endolymphatic sac surgery is an invasive procedure recommended to patients with Menière’s disease. Aims/Objectives: To provide an overview and quality assessment of the existing evidence and to provide an updated assessment of the utility of endolymphatic sac surgery in Menière’s disease. Material and Methods: We performed a systematic literature search for systematic reviews and randomized controlled trials (RCTs). The AMSTAR tool was used to assess the quality of systematic reviews and the Cochrane risk of bias tool for RCTs. The overall certainty of effects for the individual outcomes was evaluated using the GRADE approach. Results: One systematic review of high quality matched the inclusion criteria, and included three RCTs. An updated literature search from the last search date of the included review provided no further relevant RCTs. The identified RCTs individually reported a positive effect of both the placebo and active treatment groups following surgery, strongly indicative of a placebo effect. The overall certainty of the effect was very low. Conclusions and significance: There is still a lack of high-quality research suggesting that endolymphatic sac surgery provides a significant amount of symptomatic relief for Menière’s patients.

TidsskriftActa Oto-Laryngologica
Udgave nummer11
Sider (fra-til)953-958
StatusUdgivet - nov. 2019


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